Macroporous hydrogels for biomedical applications: methodology and morphology

Oxley, H.R.; Corkhill, Philip H.; Fitton, J. Helen; Tighe, Brian

doi:10.1016/0142-9612(93)90207-i

Cited by 148 publications

(86 citation statements)

References 6 publications

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“…[17][18][19] We chose poly(2-hydroxyethyl methacrylate) (pHEMA)-based hydrogels for this purpose due to their well-established biocompatibility and ease of functionalization. [23][24][25] As shown in Figure 2, we synthesized a library of anionic methacrylamides. Copolymerization with either 2-hydroxyethyl methacrylate (HEMA) or 2-hydroxyethyl methacrylamide (HEMAm) 22 formed 3-dimensional hydrogel copolymers.…”

Section: Resultsmentioning

confidence: 99%

Mineralization of Synthetic Polymer Scaffolds: A Bottom-Up Approach for the Development of Artificial Bone

2005

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ABSTRACT. The controlled integration of organic and inorganic components confers natural bone with superior mechanical properties. Bone biogenesis is thought to occur by templated mineralization of hard apatite crystals by an elastic protein scaffold, a process we sought to emulate with synthetic biomimetic hydrogel polymers. Crosslinked polymethacrylamide and polymethacrylate hydrogels were functionalized with mineral-binding ligands and used to template the formation of hydroxyapatite.Strong adhesion between the organic and inorganic materials was achieved for hydrogels functionalized with either carboxylate or hydroxy ligands. The mineral-nucleating potential of hydroxyl groups identified here broadens the design parameters for synthetic bone-like composites and suggests a potential role for hydroxylated collagen proteins in bone mineralization. Introduction:

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Section: Resultsmentioning

confidence: 99%

Mineralization of Synthetic Polymer Scaffolds: A Bottom-Up Approach for the Development of Artificial Bone

2005

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“…Applications include ophthalmic devices (e.g. contact lens), 27,28 cartilage replacements, 29 bonding agents in dental resins and bone cements, [30][31][32] and various drug delivery vehicles. 33,34 One of the major challenges for its application as a 3-dimensional scaffold of artificial bonelike materials, however, is to realize a highaffinity integration of inorganic minerals with the pHEMA-based organic scaffold.…”

Section: Introductionmentioning

confidence: 99%

Preparation of pHEMA–CP composites with high interfacial adhesion via template-driven mineralization

Song

Saiz

Bertozzi

2003

Journal of the European Ceramic Society

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ABSTRACT. We report a template-driven nucleation and mineral growth process for the high-affinity integration of calcium phosphate (CP) with a poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel scaffold. A mineralization technique was developed that exposes carboxylate groups on the surface of crosslinked pHEMA, promoting high-affinity nucleation and growth of calcium phosphate on the surface along with extensive calcification of the hydrogel interior. External factors such as the heating rate, the agitation of the mineral stock solution and the duration of the process that affect the outcome of the mineralization were investigated. This template-driven mineralization technique provides an efficient approach toward bonelike composites with high mineral-hydrogel interfacial adhesion strength.

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“…Later on these salts are washed out by equilibrating the film in distilled water. This finally results in formation of uniformly distributed micropores throughout the film [28,33,34]. In the present work we followed the later approach and used sucrose as pore forming material.…”

Section: Morphology Of the Membranementioning

confidence: 99%

Cu(II)-Cross-linked Chitosan Membrane (CCCM): Preparation, Characterization and Urea Removal Study Using the Diffusion-Cell Model (DCM)

Pathak¹,

Bajpai²

2009

Designed Monomers and Polymers

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This work focuses on the investigation of antibacterial and biocompatible properties of a porous Cu(II)-cross-linked chitosan membrane (CCCM). The membrane shows fair biocidal action against the model bacterium Escherichia coli. The total protein and HSA adsorbed was found to be 263 and 75 µg/cm 2 . Finally, the 'diffusion cell model' was used to study adsorptive removal of urea from aqueous solutions. The results indicated that nearly 84.4% urea was removed by the membrane. Therefore, the Cu(II)-cross-linked membrane has potential to be used for as an alternative for hemodialysis membrane.

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Macroporous hydrogels for biomedical applications: methodology and morphology

Cited by 148 publications

References 6 publications

Mineralization of Synthetic Polymer Scaffolds: A Bottom-Up Approach for the Development of Artificial Bone

Mineralization of Synthetic Polymer Scaffolds: A Bottom-Up Approach for the Development of Artificial Bone

Preparation of pHEMA–CP composites with high interfacial adhesion via template-driven mineralization

Cu(II)-Cross-linked Chitosan Membrane (CCCM): Preparation, Characterization and Urea Removal Study Using the Diffusion-Cell Model (DCM)

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