Macroporous nanowire nanoelectronic scaffolds for synthetic tissues

Tian, Bozhi; Liu, Jia; Dvir, Tal; Jin, Lihua; Tsui, Jonathan H.; Qing, Quan; Suo, Zhigang; Langer, Robert; Kohane, Daniel S.; Lieber, Charles M.

doi:10.1038/nmat3404

Cited by 585 publications

(627 citation statements)

References 44 publications

Supporting

Mentioning

607

Contrasting

Unclassified

Order By: Relevance

“…In its essence, “cyborganics” represents an emerging concept at the crossroads of tissue engineering, materials science, electronics, and chemistry with the daring aim to create a new class of hybrid organs and hydrogel carriers made from a combination of inanimate and biological matter 17, 18, 427. Cyborganics can be divided into two different classes:427 i) permanent hybrid organs consisting of stable matter and living tissue and ii) hydrogel carriers embedded with biological matter and degradable nanomaterials with the grand goal of regenerating dysfunctional tissues.…”

Section: Cybernetic Prostheticsmentioning

confidence: 99%

Blending Electronics with the Human Body: A Pathway toward a Cybernetic Future

et al. 2018

View full text Add to dashboard Cite

At the crossroads of chemistry, electronics, mechanical engineering, polymer science, biology, tissue engineering, computer science, and materials science, electrical devices are currently being engineered that blend directly within organs and tissues. These sophisticated devices are mediators, recorders, and stimulators of electricity with the capacity to monitor important electrophysiological events, replace disabled body parts, or even stimulate tissues to overcome their current limitations. They are therefore capable of leading humanity forward into the age of cyborgs, a time in which human biology can be hacked at will to yield beings with abilities beyond their natural capabilities. The resulting advances have been made possible by the emergence of conformal and soft electronic materials that can readily integrate with the curvilinear, dynamic, delicate, and flexible human body. This article discusses the recent rapid pace of development in the field of cybernetics with special emphasis on the important role that flexible and electrically active materials have played therein.

show abstract

Section: Cybernetic Prostheticsmentioning

confidence: 99%

Blending Electronics with the Human Body: A Pathway toward a Cybernetic Future

et al. 2018

View full text Add to dashboard Cite

show abstract

“…14 Although bio-mimetic enzyme-based electrical sensors are attractive tools, their use on a robust lab-on-a-chip platform with fast, sensitive and stable three-dimensional (3D) porous interfaces for localized real-time, long-term monitoring of cellular activities and physicochemical changes have not been demonstrated. [15][16][17][18][19] Inspired by insect tentacles, herein, we developed an unconventional antenna-like heterostructure based on direct growth of porous PB nanocube heads on the tips of TiO 2 nanowire (NW) arms, which can be used for 3D interface recognition and biosensing. Singlecrystalline TiO 2 NWs are first hydrothermally grown on conducting substrates, followed by the direct growth of nanoporous PB nanocubes on the tips of the TiO 2 NW arrays via an etching and seed-assisted process ( Figure 1, Supplementary Figure S1).…”

Section: Introductionmentioning

confidence: 99%

Bio-inspired porous antenna-like nanocube/nanowire heterostructure as ultra-sensitive cellular interfaces

Kong

Tang

et al. 2014

NPG Asia Mater

View full text Add to dashboard Cite

In this study, an unconventional antenna-like heterostructure comprised of arrays of nanoporous Prussian blue (PB) nanocube heads/TiO 2 nanowire (NW) arms (PB-TiO 2 ) is developed for efficient three-dimensional interfacial sensing of small molecules and cellular activities. Inspired by insect tentacles, which are comprised of both target recognition and signal transduction units, one-dimensional TiO 2 NW arrays are grown, followed by selective growth of nanoporous PB nanocubes on the tips of the NW arrays. Due to their high selectivity and bioaffinity toward cells, long biostability under a cell culture adhesion condition (up to 108 h) is obtained, and with its inherent bio-mimetic enzymatic activity, the obtained nanoporous PB nanocubes (head segment) serve as robust substrates for site-selective cell adhesion and culture, which allows for sensitive detection of H 2 O 2 . Simultaneously, the single-crystalline TiO 2 NWs (arm segment) provide efficient charge transport for electrode substrates. Compared with PB-functionalized planar electrochemical interfaces, the PB-TiO 2 antenna NW biointerfaces exhibit a substantial enhancement in electrocatalytic activity and sensitivity for H 2 O 2 , which includes a low detection limit (B20 nM), broad detection range (10 À8 to 10 À5 M), short response time (B5 s) and long-term biocatalytic activity (up to 6 months). The direct cultivation of HeLa cells is demonstrated on the PB-TiO 2 antenna NW arrays, which are capable of sensitive electrochemical recording of cellular activity in real time, where the results suggest the uniqueness of the biomimic PB-TiO 2 antenna NWs for efficient cellular interfacing and molecular recognition.

show abstract

“…Such a study is difficult but immensely useful because the hybrid (metal-semiconductor) nanostructures can be used for a wide range of applications such as SERS, [16][17][18] photonics, 4,5 renewable energy 3 and biomedicine. [19][20][21] This study addresses whether the newly observed optical effects, LMR and SWs in an NW system, can positively affect the plasmonic E field for photonic applications.…”

Section: Introductionmentioning

confidence: 99%

Plasmon management in index engineered 2.5D hybrid nanostructures for surface-enhanced Raman scattering

Huang¹,

Chen

et al. 2014

NPG Asia Mater

View full text Add to dashboard Cite

Leaky mode resonance (LMR) and optical standing waves (SWs) generated in suitably illuminated vertically aligned supported nanowires (NWs) were demonstrated to enhance the plasmonic electric (E) field behavior of silver nanoparticles (AgNPs) dispersed on the wires. The combination of LMR and SW can significantly enhance the local plasmonic E field around highdensity AgNPs. The results of the finite difference time domain (FDTD) calculations were experimentally verified by comparing the surface-enhanced Raman scattering (SERS) sensitivity, which is directly dependent on the E field, in AgNP-coated silicon, germanium and silver NWs. As LMR and SW are functions of the substrate optical index (n, k), an engineering of the indices predicted a (3.88, 0) theoretical value to maximize the plasmonic E-field on the hybrid scaffold at a given AgNP density. These SERS substrates were utilized for the detection of marine toxins, L-BMAA (2-amino-3-(methylamino) propionic acid hydrochloride) and Malachite green, which are used extensively in seafood. AgNP-decorated silicon NWs, whose index (3.88, 0.02) lies close to the theoretically predicted value, exhibit at least pico-molar sensitivity toward those marine toxins. A plasmon management strategy is developed that could assist in lowering the detection level of environmental toxins by SERS. NPG Asia Materials (2014) 6, e123; doi:10.1038/am.2014.67; published online 12 September 2014 INTRODUCTIONThe involvement of plasmonics 1 in applications such as biosensing 2 through surface-enhanced Raman scattering (SERS), energy, 3 photodetectors 4 and lasers, 5 among others, is extensive because surface plasmons can concentrate and manipulate light energy on scales lower than their diffraction limit. 6 The common goal has generally been to be able to intensify and control the plasmonic electric (E) fields in preferred locations within the material. For example, the so-called 'hot-spots' in SERS, for molecular sensing, are reportedly the regions of extraordinarily intense E field at the junctions of critically close gold (Au) or silver (Ag) nanoparticles (NPs). The interparticle spacing 7 and fractal-like aggregations 8 within the metal NPs were observed to be more critical for the E enhancement than the basic material properties or the size of the NPs.The recent observation of enhanced optical absorption in suitably illuminated semiconductor nanowires (NWs) via leaky mode resonances (LMRs) 9 opens up the possibility of using LMR for the E-field enhancement of metal NPs. In addition, researchers have observed optical standing waves (SWs) along the length of the NWs when studying optically illuminated vertically aligned NW structures grown on a substrate by finite difference time domain (FDTD) calculations. However, the effect of the SWs or the LMR in modulating the total effective E field has been ignored or addressed inadequately. The fact that Ag-or AuNP-dispersed vertically aligned 1D NW/nanorods 10

show abstract

Macroporous nanowire nanoelectronic scaffolds for synthetic tissues

Cited by 585 publications

References 44 publications

Blending Electronics with the Human Body: A Pathway toward a Cybernetic Future

Blending Electronics with the Human Body: A Pathway toward a Cybernetic Future

Bio-inspired porous antenna-like nanocube/nanowire heterostructure as ultra-sensitive cellular interfaces

Plasmon management in index engineered 2.5D hybrid nanostructures for surface-enhanced Raman scattering

Contact Info

Product

Resources

About