Macular Hole and Macular Detachment in Severe Hypertensive Retinochoroidopathy

Khairallah, Moncef; Yahia, Salim Ben; Messaoud, R.; Ladjimi, A.; Zaouali, Sonia; Garfatta, A.

doi:10.1001/archopht.121.10.1504

Cited by 2 publications

(5 citation statements)

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“…The referred case manifested the retinal oedema, intraretinal hemorrhage, cotton-wool spots, hard exudates, and elschnig spots in the fundus photography, consistent with previous cases ( 1 , 3 , 4 ). Retinal oedema and elschnig spots were clear signs of hypertensive choroidopathy.…”

Section: Discussionsupporting

confidence: 88%

“…Acute hypertensive retinochoroidopathy is a very rare and severe ocular disease that results in a sharp decrease in vision associated to malignant hypertension and commonly occurring in young patients ( 1 ). Malignant hypertension is the most severe form of hypertension associated with preeclampsia, renal artery stenosis, and pheochromocytoma ( 3 ).…”

Section: Discussionmentioning

confidence: 99%

“…Almost 80% of untreated patients with the condition will die within 2 years ( 2 ). The combination of hypertensive retinopathy and choroidopathy, termed hypertensive retinochoroidopathy, is a rare and severe ocular condition that results in a sharp visual reduction due to malignant hypertension ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

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Acute Hypertensive Retinochoroidopathy Secondary to an Anti-cancer Drug (apatinib): The First Case Report

et al. 2021

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Background: Acute hypertensive retinochoroidopathy is a rare, severe ocular disease, characterized by retinal and choroidal ischaemia. Untreated cases are associated with high mortality and poor visual outcomes. Patients subjected to treatment with the anti-neoplasic drug apatinib may trigger this disease. The purpose of this article is to describe in detail an acute hypertensive retinochoroidopathy in a young Chinese woman treated with apatinib.Case Presentation: A 40-year-old young Chinese woman presented a sudden but painless reduction of visual acuity in both eyes. She was previously diagnosed with gastric cancer and metastatic ovarian adenocarcinoma. The treatment consisted radical gastrectomy, transabdominal hysterectomy, bilateral adnexectomy, and 250 mg oral apatinib per day. After 58 days of apatinib administration, the patient immediately sought consult for a sudden decrease in vision. Her blood pressure was 208/136 mmHg and, based on the clinical manifestations, the patient was diagnosed with acute hypertensive retinochoroidopathy.Conclusions: This is the first case report of an apatinib-related acute hypertensive retinochoroidopathy diagnosed using fundal photograph, fundus fluorescein angiography, and spectral-domain optical coherence tomography simultaneously. It is crucial to develop a suitable strategy for management and prevention of this adverse event.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Acute Hypertensive Retinochoroidopathy Secondary to an Anti-cancer Drug (apatinib): The First Case Report

et al. 2021

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“…Atraumatic macular holes in young patients are rare. A literature search revealed only two cases of full‐thickness macular holes in young patients, which occurred after episodes of severe hypertensive retinopathy 2,3 . In our case, hypertensive choroidopathy was more severe than previously reported cases.…”

Section: Discussionmentioning

confidence: 43%

“…Macular holes usually develop in elderly women and most are idiopathic 1 . Occasionally, they can develop in traumatized eyes and, in rare cases, have been reported in patients with hypertensive chorioretinopathy 2,3 . However, spontaneous closure of a macular hole is uncommon and has been reported to occur in only 3–5% of full‐thickness macular holes 4 .…”

Section: Introductionmentioning

confidence: 99%