Macular Measurements Using Spectral-Domain Optical Coherence Tomography in Chinese Myopic Children

Chen, Si; Wang, Bingsong; Dong, Ning; Ren, Xiaotong; Zhang, Tuohong; Xiao, Lin

doi:10.1167/iovs.14-13894

Cited by 37 publications

(46 citation statements)

References 37 publications

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“…We repeated each of the LMM analyses, using baseline axial length as a factor instead of refractive error group, and found similar trends of statistically significant associations between axial length and retinal thickness, indicating that the topographical changes in thickness associated with myopia are related to the increased axial length of myopic eyes. Although not a universal finding [12,13], previous studies using SD-OCT have also noted a thinning of the total retina in the parafoveal and/or the perifoveal region associated with myopia in childhood of similar magnitude to that found in the current study [14,19]. …”

Section: Discussionsupporting

confidence: 79%

Longitudinal changes in macular retinal layer thickness in pediatric populations: Myopic vs non-myopic eyes

2017

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Knowledge of the normal in vivo thickness of the retina, and its individual layers in pediatric populations is important for diagnosing and monitoring retinal disorders, and for understanding the eye’s normal development and the impact of eye growth and refractive error such as myopia (short-sightedness) upon retinal morphology. In this prospective, observational longitudinal study, total retinal thickness (and individual retinal layer thickness) and the changes in retinal morphology occurring over an 18-month period were examined in 101 children with a range of refractive errors. In childhood, the presence of myopia was associated with subtle but statistically significant (p<0.05) changes in the topographical thickness distribution of macular retinal thickness (and retinal layer thickness), characterised by a thinning of the parafoveal retina (and parafoveal or perifoveal thinning in most outer and inner retinal layers). The parafoveal retina was on average 6 μm thinner in myopic children. However, over 18 months, longitudinal changes in retinal thickness and individual layers were of small magnitude (average changes of less than 2 μm over 18 months), indicative of a high degree of stability in retinal morphology in healthy adolescent eyes, despite significant eye growth over this same period of time. This provides the first detailed longitudinal assessment of macula retinal layer morphology in adolescence, and delivers new normative data on expected changes in retinal structure over time and associated with myopia during this period of childhood development.

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Section: Discussionsupporting

confidence: 79%

Longitudinal changes in macular retinal layer thickness in pediatric populations: Myopic vs non-myopic eyes

2017

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“…Recent studies have reported that the foveal thickness of myopic patients is thicker than that in emmetropia patients and increases with progression of myopia [43, 44]. Although the present study showed no significant differences of foveal thicknesses, because there was no significant difference in myopia, parafoveal retinal thickness was associated with β -PPA, which may be attributed in part to the difference in mGCIPL thicknesses.…”

Section: Discussioncontrasting

confidence: 73%

“…Recent studies using OCT have shown that the fovea is thicker in myopic eyes [43, 45]. Several studies have hypothesized that the increased axial length causes mechanical stretching of the sclera at the posterior pole.…”

Section: Discussionmentioning

confidence: 99%

Ganglion Cell-Inner Plexiform Layer, Peripapillary Retinal Nerve Fiber Layer, and Macular Thickness in Eyes with Myopicβ-Zone Parapapillary Atrophy

Kwon

Choi

Kim

et al. 2016

Journal of Ophthalmology

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Purpose. To assess the correlations of myopic β-zone parapapillary atrophy (β-PPA) with the optic nerve head (ONH) and retina. Methods. We selected 27 myopic patients who showed prominent β-PPA in one eye and no β-PPA in the other eye. We studied their macula, macular ganglion cell-inner plexiform layer (mGCIPL), peripapillary retinal nerve fiber layer (pRNFL) thickness, and ONH parameters using optical coherence tomography. Results. The average of five out of six sectors and minimum values of mGCIPL thicknesses in eyes with prominent β-PPA discs were significantly less than those of the control eyes. The results of clock-hour sector analyses showed significant differences for pRNFL thickness in one sector. In the ONH analyses, no significant difference was observed between myopic β-PPA and control eyes. The macular thickness of the β-PPA eyes was thinner than control eyes in all sectors. There was a significant difference between the two groups in three sectors (the inner superior macula, inner temporal macula, and inner inferior macula) but there was no significant difference in the other sectors, including the fovea. Conclusions. The myopic β-PPA eyes showed thinner mGCIPL, parafovea, and partial pRNFL layers compared with myopic eyes without β-PPA.

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“…As established through OCT imaging, there is a significant negative correlation between axial length and retinal thickness . Chen et al deduced that despite the tendency for a slightly greater foveal thickness, Chinese children with moderately‐to‐highly myopic eyes had a decreased average macular thickness and volume in comparison with emmetropic children. The perifoveal area has been established as the zone of greatest thinning in myopic children .…”

Section: Interpretation Of Paediatric Oct Imaging: Normative Datamentioning

confidence: 99%

“…Chen et al deduced that despite the tendency for a slightly greater foveal thickness, Chinese children with moderately‐to‐highly myopic eyes had a decreased average macular thickness and volume in comparison with emmetropic children. The perifoveal area has been established as the zone of greatest thinning in myopic children . Similarly, OCT analysis of RNFL thickness of 104 children in Hong Kong showed a significant inverse relationship with the axial length of the eye .…”

Section: Interpretation Of Paediatric Oct Imaging: Normative Datamentioning

confidence: 99%

Optical coherence tomography in paediatric clinical practice

Maccora

Sheth

Ruddle

2019

Clinical and Experimental Optometry

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Optical coherence tomography is a non-invasive ocular imaging technique that is frequently used in the diagnosis and monitoring of optic nerve or retinal disease. Advances in optical coherence tomography speed and image processing capability allow increased use of the modality in clinical practice, especially in younger children. This review outlines the challenges involved in imaging children, highlights the technological progress, the importance of acquiring normative data and, finally, focuses on the clinical applicability of optical coherence tomography in our paediatric population with various ocular conditions.

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Macular Measurements Using Spectral-Domain Optical Coherence Tomography in Chinese Myopic Children

Abstract: Our study highlights the variations and sex differences of macular thickness/volume in Chinese myopic children using SD-OCT.

Cited by 37 publications

References 37 publications

Longitudinal changes in macular retinal layer thickness in pediatric populations: Myopic vs non-myopic eyes

Longitudinal changes in macular retinal layer thickness in pediatric populations: Myopic vs non-myopic eyes

Ganglion Cell-Inner Plexiform Layer, Peripapillary Retinal Nerve Fiber Layer, and Macular Thickness in Eyes with Myopicβ-Zone Parapapillary Atrophy

Optical coherence tomography in paediatric clinical practice

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