2019
DOI: 10.1097/iae.0000000000002123
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Macular Microvascular Networks in Healthy Pediatric Subjects

Abstract: We report data for pediatric OCTA parameters in healthy subjects. Several variables influence the density of macular microvascular networks, and these factors should be considered in the OCTA study of pediatric eye disorders.

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Cited by 70 publications
(68 citation statements)
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“…These results agreed with the study from Rao 23 and disagree with others. Borrelli et al 22 reported a higher superficial vessel density in boys than in girls when measuring macular vessel densities with OCTA in children.…”
Section: Discussionmentioning
confidence: 99%
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“…These results agreed with the study from Rao 23 and disagree with others. Borrelli et al 22 reported a higher superficial vessel density in boys than in girls when measuring macular vessel densities with OCTA in children.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies have reported normative macular vessel density data in healthy volunteers; however small, sample sizes and potential selection bias have precluded reliable assessment of systemic associations. [11][12][13][14][22][23][24] The current large-scale population-based study provides normative macular vessel density data measured with OCTA and its associations. The results showed that a lower superficial vessel density was significantly associated with older age, male sex, worse BCVA, longer AL, thinner inner retinal thickness, and higher HbA1c level.…”
Section: Discussionmentioning
confidence: 99%
“…To evaluate the PNPCA and the average signal void size, we analyzed the images as already described. 15,21,22 In brief, the PNPCA was computed as the percentage of pixels in the CC en face image (slab 30-lm thick starting 31 lm posterior to the RPE reference) below a ''non-perfusion'' (or noise) threshold, which was calculated with ImageJ software version 1.50 (National Institutes of Health, Bethesda, MD, USA; http://rsb. info.nih.gov/ij/index.html) as the mean of all the pixel values in the outer avascular retina.…”
Section: Image Processingmentioning
confidence: 99%
“…1). 21,22 In brief, the drusen area was identified on the ''RPE elevation'' map elaborated by the AngioVue software. This image was imported into ImageJ, and the ''Split Channels'' function was carried on to obtain the ''green channel'' image.…”
Section: Image Processingmentioning
confidence: 99%
“…This choice was due to histologic and technical reasons: (1) there is a strong body of evidence suggesting the retinal plexuses merge at the edge of the FAZ, which may be thus considered a singular structure throughout the entire foveal thickness [33]; and (2) assessing the FAZ size at different segments may lead to increased variability of measurements [34]. The FAZ size was demonstrated to increase with age [35,36] and disease (e.g. myopia, hypertension) [37,38].…”
Section: Evaluation Of the Vascular Layers With Octamentioning
confidence: 99%