Macular retinal and nerve fiber layer thickness in early glaucoma: Clinical correlations

Arvanitaki,; Tsilimbaris, Miltiadis K.; Pallikaris, Aristofanis I.; Moschandreas, I; Minos, Evangelos; Pallikaris, Ig; Detorakis, E T

doi:10.4103/0974-9233.95251

Cited by 16 publications

(7 citation statements)

References 26 publications

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“…Macular retinal and nerve fiber layer thickness in early glaucoma was studied by Arvanitaki V et al .The finding that RT was significantly lower in early manifest glaucoma patients and glaucoma suspects indicates that the transposition of the OCT fast RNFL thickness (3.4) protocol from the peri-papillary area to the peri-macular area can be used for early glaucoma diagnosis. Intraretinal changes in early glaucoma, likely precede nerve fiber changes [16]. Similarly, the present study showed statically significant lower mean inner macular thickness among glaucoma patients as compared to normal subjects.…”

Section: Discussionsupporting

confidence: 79%

Comparison of macular parameters in primary open angle glaucoma patients using cirrus optical coherence tomography

Sharma

Yadav

2019

Trop J Ophthalmol Otolaryngol

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Aim: To compare macular parameters using Cirrus optical coherence tomography (OCT) in primary open angle glaucoma (POAG) patients with the normal subjects. Materials and Methods: This observational case control study included primary open angle glaucoma (POAG) patients (n = 184 eyes) and healthy subjects in the control group (n = 184 eyes). All subjects underwent detailed history, complete ocular examination. Complete ocular examination included best corrected visual acuity (BCVA), slit lamp examination, intraocular pressure (IOP), central corneal thickness, Gonioscopy, and dilated fundus biomicroscopy. Field analysis was done by white on white Humphrey Field Analyzer (Carl Zeiss). Optical coherence tomography imaging of macular area was performed using Cirrus HD-OCT. (Cirrus HD-OCT MODEL 4000, Carl Zeiss, Meditec Inc. Dublin CA, 94568).In both these groups, parameters analyzed were central macular thickness (CMT), inner inferior macular thicknesses (IIMT), inner superior macular thicknesses (ISMT),inner nasal macular thicknesses (INMT), inner temporal macular thicknesses (ITMT), and central macular volume (CMV). Results: The POAG group had significantly decreased values of CMT, IIMT, ISMT, INMT, ITMT and CMV compared to control group, Thus, macular thickness and volume parameters may be used for making the diagnosis of glaucoma especially in patients with abnormalities of disc. Statistical analysis done using student t-test. SPSS 13.0 software was used to calculate p value. There was statistically significant difference found in all macular parameters between cases and controls. (p=0.001). Conclusion: Macular parameters, such as total macular volume, inner macular thickness and outer macular thickness can be used in addition to RNFL thickness to aid in the diagnosis of early glaucoma using OCT, in certain conditions, where RNFL parameters may be distorted, such as disk abnormalities or peripapillary atrophy macular parameters may be relied upon. Macular thickness parameters showed thinning in diagnosed cases of glaucoma.

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Section: Discussionsupporting

confidence: 79%

Comparison of macular parameters in primary open angle glaucoma patients using cirrus optical coherence tomography

Sharma

Yadav

2019

Trop J Ophthalmol Otolaryngol

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“…Tan et al [ 22 ] found that the macula thicknesses in perimetric glaucoma patients were thinner. In their study, Arvanitaki et al [ 23 ] compared patients with a suspicion of glaucoma who have early manifest glaucoma and nontreated IOP averages of 17 mmHg. They found that although there was no peripapillary RNFL change, there was a significant thinning in the superior, inferior, nasal, and temporal macular thicknesses of the patient group when compared with the control group.…”

Section: Discussionmentioning

confidence: 99%

Optic Disc, Macula, and Retinal Nerve Fiber Layer Measurements Obtained by OCT in Thyroid-Associated Ophthalmopathy

Sayın¹,

Yeter

Arıtürk

2016

Journal of Ophthalmology

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Aim. To compare the measurements of retinal nerve fiber layer (RNFL), macula and optic disc parameters obtained by optical coherence tomography (OCT), and intraocular pressure (IOP) between the patients with thyroid-associated ophthalmopathy (TAO) and healthy controls. Methods. One hundred and thirty-two eyes of 66 patients with TAO and 72 eyes of 36 healthy controls were included in the study. Proptosis level was determined by Hertel exophthalmometer. Optic disc, peripapillary retinal nerve fiber layer, and macula parameters were measured by OCT. All measurements of the patients were compared with those of age- and sex-matched healthy controls. Results. No statistically significant difference was found between the patients with TAO and control group in terms of demographic characteristics (P > 0.05). Exophthalmometer measurements and IOP were higher in TAO group (P < 0.05). Mean macula thicknesses in TAO and control groups were 239.3 ± 29.8 μm and 246.6 ± 31.8 μm, respectively, and the difference between the groups was statistically significant (P = 0.000). TAO group had thinner inferior RNFL thickness and macular thicknesses (superior, inferior, temporal, and nasal) and higher disc area and C/D ratio when compared with the control group (P < 0.05). Conclusion. IOP, disc area, and C/D area ratio were higher in the patients with TAO and the thicknesses of macula and inferior RNFL were thinner when compared with healthy controls. This trial is registered with registration number at clinicaltrials.gov NCT02766660.

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“… 4 – 11 Furthermore, macular thickness measurement was suggested to be useful in the early detection of glaucoma. 4 , 12 , 13 Optical coherence tomography (OCT) is a noninvasive imaging modality capable of objectively measuring the macular thickness and peripapillary RNFL thickness in children as young as the age of 3. 14 – 16 The purpose of this study was to investigate the association between macular thickness and peripapillary RNFL thickness in Chinese children.…”

Section: Introductionmentioning

confidence: 99%

The Association Between Macular Thickness and Peripapillary Retinal Nerve Fiber Layer Thickness in Chinese Children

Lee

Yau²,

Woo³

et al. 2015

Medicine

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To investigate the association between macular thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in Chinese children.This cross-sectional study recruited consecutive cases of healthy pediatric subjects aged 4 to 18 from Caritas Medical Centre in Hong Kong Special Administrative Region, China, from 2013 to 2014. Subjects with only eye, ocular tumors, congenital glaucoma, congenital cataract, congenital nystagmus, microphthalmos, optic nerve or retinal disease, active ocular infections, corneal scars, and severe visual impairment of any cause were excluded. Peripapillary RNFL thickness and macular thickness at 1mm-diameter fovea center (C1), 3mm-diameter temporal quadrant (T3), and 3mm- diameter nasal quadrant (N3) were measured with optical coherence tomography. Best-corrected visual acuity, axial length, and cycloplegic refraction were also recorded. Spearman correlation was used to analyze the association between T3, C1, and N3 with each of the following: average and quadrant RNFL thickness, axial length, and spherical equivalent.In 179 subjects, the mean age was 7.9 ± 3.6 years. There were 90 male and 89 female subjects, all of Chinese ethnicity. The mean spherical equivalent was −0.1 ± 3.1 D and mean axial length was 22.9 ± 1.4 mm. There were significant and positive correlations of the average (T3: r = 0.20, P = 0.04; N3: r = 0.2, P = 0.005), superior (T3: r = 0.20, P = 0.03; N3: r = 0.2, P = 0.03), and inferior (T3: r = 0.20, P = 0.02; N3: r = 0.2, P = 0.01) peripapillary RNFL thicknesses with the T3 and N3 macular thicknesses but not C1. The nasal peripapillary RNFL thickness was also positively correlated with T3 (r = 0.20, P = 0.01). There were no significant associations between the macular thickness (T3, C1, N3) with neither the spherical equivalent (P > 0.2) nor the axial length (P > 0.3).The macular thickness was positive correlated with the peripapillary RNFL thickness in a population of healthy Chinese children.

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Macular retinal and nerve fiber layer thickness in early glaucoma: Clinical correlations

Cited by 16 publications

References 26 publications

Comparison of macular parameters in primary open angle glaucoma patients using cirrus optical coherence tomography

Comparison of macular parameters in primary open angle glaucoma patients using cirrus optical coherence tomography

Optic Disc, Macula, and Retinal Nerve Fiber Layer Measurements Obtained by OCT in Thyroid-Associated Ophthalmopathy

The Association Between Macular Thickness and Peripapillary Retinal Nerve Fiber Layer Thickness in Chinese Children

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