Macular translocation for surgical management of subfoveal choroidal neovascularizations in patients with AMD: first results

Wolf, Sebastian; Lappas, Alexandra; Weinberger, A; Kirchhof, Bernd

doi:10.1007/s004170050194

Cited by 104 publications

(43 citation statements)

References 18 publications

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“…Postoperative complications included retinal detachment in 3 eyes and macular pucker in 1 eye. 43 Compared with laser photocoagulation and photodynamic therapy, macular translocation with 360°reti-notomy offers the possibility to treat patients with classic CNV as well as occult CNV or massive hemorrhages. Precise indications for macular translocation have not been well defined and should evolve as more information becomes available from controlled prospective trials.…”

Section: Commentmentioning

confidence: 99%

Macular Translocation With 360° Retinotomy for Exudative Age-Related Macular Degeneration

Aisenbrey

Lafaut²,

Szurman³

et al. 2002

Arch Ophthalmol

130

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Background: Macular rotation surgery comprises surgical extraction of choroidal neovascular membranes in age-related macular degeneration (AMD) and translocation of the foveal neural retina over adjacent retinal pigment epithelium.Objective: To determine whether macular translocation with 360°retinotomy can stabilize and/or improve visual acuity in patients with subfoveal choroidal neovascularization (CNV) secondary to AMD.Design: This study consisted of a standardized surgical procedure on a series of 90 consecutive patients and follow-up examinations at fixed intervals for 12 months.Participants: All patients in this study had experienced recent visual loss resulting from subfoveal CNV caused by AMD. Twenty-six patients had major macular subretinal hemorrhage, 39 patients had occult subfoveal CNV, and 25 patients had classic subfoveal CNV.Methods: Macular translocation surgery was performed between 1997 and 1999. The patients were examined preoperatively and at 3, 6, and 12 months postoperatively, including visual acuity, microperimetry, angiography, and orthoptic assessment.Results: Visual acuity increased by 15 or more letters in 24 patients, remained stable in 37 patients, and deteriorated by 15 or more letters in 29 patients at 12 months postoperatively. A secondary procedure was necessary in 17 patients because of severe complications; proliferative vitreoretinopathy was observed in 17 eyes, macular pucker in 5 eyes, and macular hole in 1 patient. Conclusion:Macular translocation is a technically demanding surgical procedure. Although the procedure has a high rate of surgical and postoperative complications, the functional and anatomical results appear to be promising for selected patients with subfoveal CNV secondary to AMD.

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Section: Commentmentioning

confidence: 99%

Macular Translocation With 360° Retinotomy for Exudative Age-Related Macular Degeneration

Aisenbrey

Lafaut²,

Szurman³

et al. 2002

Arch Ophthalmol

130

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“…So far, CNV removal in ARMD has been unable to maintain or revive subfoveal RPE. As RPE cells are considered crucial for maintenance and function of photoreceptors, restoration of RPE cell function is under investigation either by translocation of the macula to neighboring intact RPE [8,9,20,40] or by transplantation/translocation of pigmented cells. Autologous translocation of RPE cells has been reported [5,25].…”

Section: Introductionmentioning

confidence: 99%

Translocation of iris pigment epithelium in patients with exudative age-related macular degeneration — long term results

Lappas¹,

Foerster²,

Weinberger³

et al. 2004

The Macula

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Purpose: To report the practicability and efficacy of autologous iris pigment epithelium (IPE) translocation in exudative age-related macular degeneration (ARMD) over 1 year. Methods: The consecutive interventional case series included 56 patients with exudative ARMD. During vitrectomy the submacular neovascular membrane (CNV) was removed and IPE cells, harvested from a peripheral iridectomy, were injected into the submacular space. Included were patients with subfoveal occult CNV (11 eyes), classic CNV (10 eyes), mixed CNV (17 eyes), CNV with a pigment epithelial detachment (13 eyes) or CNV with a hemorrhage (5 eyes). Outcome measures were visual acuity, foveal fixation, size of CNV and rate of recurrence based on fluorescence angiographic imaging. Results: All patients underwent successful surgical removal of the CNV with consecutive subretinal IPE injection.

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“…This makes it unsuitable for the first eye affected or for larger lesions. [15][16][17][18][19] RPE-choroid grafts can be used on first eyes, as the foveal photoreceptors are not displaced, and also have the potential for good improvements in vision. 14,[20][21][22][23][24][25][26][27][28][29][30][31][32] Free RPE-BM-choriocapillaris patch grafts allow larger subfoveal defects to be treated than has proved possible with either translocation surgery or submacular rotation of pedicled grafts.…”

Section: Discussionmentioning

confidence: 99%

Assessment of 180° Rotation of the Choroid as a Novel Surgical Treatment for Age-Related Macular Degeneration

Lee

Singh

Jones

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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Macular translocation for surgical management of subfoveal choroidal neovascularizations in patients with AMD: first results

Abstract: In our series rapid improvement of visual function was observed in one patient only, even if the macula appeared ophthalmoscopically and angiographically normal. Vitreoretinal complications occurred frequently during follow-up.

Cited by 104 publications

References 18 publications

Macular Translocation With 360° Retinotomy for Exudative Age-Related Macular Degeneration

Macular Translocation With 360° Retinotomy for Exudative Age-Related Macular Degeneration

Translocation of iris pigment epithelium in patients with exudative age-related macular degeneration — long term results

Assessment of 180° Rotation of the Choroid as a Novel Surgical Treatment for Age-Related Macular Degeneration

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