MAGE-A family: Attractive targets for cancer immunotherapy

Sang, Meixiang; Lian, Yishui; Zhou, Xin; Shan, Baoen

doi:10.1016/j.vaccine.2011.09.014

Cited by 96 publications

(80 citation statements)

References 49 publications

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“…Since their discovery as tumor antigens (3), MAGE-A genes have been mainly studied as potential targets for cancer vaccines (4). In the last years, our and other groups have started studying the cellular function of different MAGE-A proteins, showing their associated pro-oncogenic functions mostly through regulation of specific transcription factors.…”

Section: Mageb2 Belongs To the Melanoma Antigen Gene (Mage-i)mentioning

confidence: 99%

Human MageB2 Protein Expression Enhances E2F Transcriptional Activity, Cell Proliferation, and Resistance to Ribotoxic Stress

Peche

Ladelfa

Toledo

et al. 2015

Journal of Biological Chemistry

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Background: MageB2 is a tumor-specific antigen with unknown function. Results: Through a mechanism involving histone deacetylases, MageB2 enhances E2F activity and resistance to Actinomycin D. Conclusion: MageB2 is a protein conferring proliferation properties and resistance to ribotoxic stress to tumor cells. Significance: Expression of MageB2 in human tumors could be a marker of chemotherapy refraction.

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Section: Mageb2 Belongs To the Melanoma Antigen Gene (Mage-i)mentioning

confidence: 99%

Human MageB2 Protein Expression Enhances E2F Transcriptional Activity, Cell Proliferation, and Resistance to Ribotoxic Stress

Peche

Ladelfa

Toledo

et al. 2015

Journal of Biological Chemistry

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“…The expression of the gene family of cancer/ testis antigens is high in testis and silenced in somatic tissues but is activated due to DNA demethylation specifically in many invasive cancers (De Smet et al 1996. MAGE genes are promising targets for anti-tumor immunotherapy (Sang et al 2011).…”

Section: Ing1b Targets Gadd45a To Mageb2 Demethylation Sitesmentioning

confidence: 99%

Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3

et al. 2013

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Active DNA demethylation regulates epigenetic gene activation in numerous processes, but how the target site specificity of DNA demethylation is determined and what factors are involved are still poorly understood. Here we show that the tumor suppressor inhibitor of growth protein 1 (Ing1) is required for targeting active DNA demethylation. Ing1 functions by recruiting the regulator of DNA demethylation growth arrest and DNA damage protein 45a (Gadd45a) to histone H3 trimethylated at Lys 4 (H3K4me3). We show that reduced H3K4 methylation impairs recruitment of Gadd45a/Ing1 and gene-specific DNA demethylation. Our results indicate that histone methylation directs DNA demethylation.

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“…A tumour-specific antigen, mage-a3 is expressed by a variety of cancer cells, but not by normal ones. The strict tumour-specific expression of mage-a3 has prompted immunotherapeutic trials 96 . Nonsmall-cell lung carcinoma is among the tumours that express mage-a3.…”

Section: Future Of Nsclcmentioning

confidence: 99%

The Role of Molecular Pathology in Non-Small-Cell Lung Carcinoma—Now and in the Future

2012

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In recent years, better understanding of the molecular biology of non-small-cell lung carcinoma (nsclc) has led to a revolution in the work-up of these neoplasms. As a pathology diagnosis, "nsclc" without further attempt at subclassification is no longer accepted as a standard of care; separating squamous cell carcinoma from adenocarcinoma and large-cell carcinoma carries implications for prognosis and treatment decisions. Currently, detection of the presence in nsclc of mutations involving the epidermal growth factor receptor (EGFR) gene and fusion of the N-terminal portion of the protein encoded by EML4 (echinoderm microtubule-associated protein-like 4 gene) with the intracellular signaling portion of the receptor tyrosine kinase encoded by ALK (anaplastic lymphoma kinase gene)-that is, EML4-ALK-and variants has become routine in many centres because patients having tumours harbouring such alterations might benefit from tyrosine kinase inhibitors as part of their treatment regimen.The purpose of the present review is to highlight important aspects of the screening for molecular derangements in nsclc and to briefly discuss the emergence of possible future biomarkers.

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MAGE-A family: Attractive targets for cancer immunotherapy

Cited by 96 publications

References 49 publications

Human MageB2 Protein Expression Enhances E2F Transcriptional Activity, Cell Proliferation, and Resistance to Ribotoxic Stress

Human MageB2 Protein Expression Enhances E2F Transcriptional Activity, Cell Proliferation, and Resistance to Ribotoxic Stress

Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3

The Role of Molecular Pathology in Non-Small-Cell Lung Carcinoma—Now and in the Future

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