MAGEC2 is a sensitive and novel marker for seminoma: a tissue microarray analysis of 325 testicular germ cell tumors

Bode, P.; Barghorn, André; Fritzsche, Florian; Riener, Marc‐Oliver; Kristiansen, Glen; Knuth, Alexander; Moch, Holger

doi:10.1038/modpathol.2011.6

Cited by 35 publications

(27 citation statements)

References 25 publications

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“…Expression of KIT depends on the antibody used. 27,45 Rajpert-De Meyts et al 35 already demonstrated that spermatocytic seminoma expresses the cancer testis antigen MAGEA4.…”

Section: Discussionmentioning

confidence: 99%

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Cancer testis antigen expression in testicular germ cell tumorigenesis

et al. 2014

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Cancer testis antigens are encoded by germ line-associated genes that are present in normal germ cells of testis and ovary but not in differentiated tissues. Their expression in various human cancer types has been interpreted as 're-expression' or as intratumoral progenitor cell signature. Cancer testis antigen expression patterns have not yet been studied in germ cell tumorigenesis with specific emphasis on intratubular germ cell neoplasia unclassified as a precursor lesion for testicular germ cell tumors. Immunohistochemistry was used to study MAGEA3, MAGEA4, MAGEC1, GAGE1 and CTAG1B expression in 325 primary testicular germ cell tumors, including 94 mixed germ cell tumors. Seminomatous and non-seminomatous components were separately arranged and evaluated on tissue microarrays. Spermatogonia in the normal testis were positive, whereas intratubular germ cell neoplasia unclassified was negative for all five CT antigens. Cancer testis antigen expression was only found in 3% (CTAG1B), 10% (GAGE1, MAGEA4), 33% (MAGEA3) and 40% (MAGEC1) of classic seminoma but not in nonseminomatous testicular germ cell tumors. In contrast, all spermatocytic seminomas were positive for cancer testis antigens. These data are consistent with a different cell origin in spermatocytic seminoma compared with classic seminoma and support a progression model with loss of cancer testis antigens in early tumorigenesis of testicular germ cell tumors and later re-expression in a subset of seminomas.

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“…Expression of KIT depends on the antibody used. 27,45 Rajpert-De Meyts et al 35 already demonstrated that spermatocytic seminoma expresses the cancer testis antigen MAGEA4.…”

Section: Discussionmentioning

confidence: 99%

“…27 In summary, the tissue microarray contained testicular tumor components of 254 seminomas, 89 embryonal carcinomas, 51 yolk sac tumors, 54 teratomas, 10 choriocarcinomas and 4 spermatocytic seminomas. Additionally, we included intratubular germ cell neoplasia unclassified and non-tumor testicular tissue from 20 tumor patients.…”

Section: Tissue Microarraymentioning

confidence: 99%

Cancer testis antigen expression in testicular germ cell tumorigenesis

et al. 2014

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“…This newer allows a reliable distinction of seminoma from embryonal carcinomas. Therefore, MAGEC2 represents an additional tool for the differential diagnosis of testicular germ cell tumours (Bode et al, 2011).…”

Section: Genetic Markersmentioning

confidence: 99%

Classification, epidemiology and therapies for testicular germ cell tumours

Vasdev¹,

Moon²,

Thorpe³

2013

Int. J. Dev. Biol.

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Testicular germ cell tumours (TGCT) account for between 1% and 1.5% of male neoplasms and 5% of urological tumours in general. They are classified broadly into Seminoma, which resemble primordial germ cells (PGCs), and Non-Seminoma, which are either undifferentiated (embryonal carcinoma) or differentiated (exhibiting a degree of embryonic (teratoma) or extra-embryonic (yolk sac choriocarcinoma) patterning). We present the current details of the latest classification, epidemiology and treatment aspects of TGCT in the UK in our review.

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“…Although the morphological features of seminoma are similar irrespective of primary tumor site, differences have been described between the expression of immunohistochemical markers and genetic profiles of testicular and mediastinal seminomas (5)(6)(7)(8). Several more recent publications have investigated the expression pattern of various novel immunohistochemical markers -including stem cell markers -in testicular seminomas (9)(10)(11)(12)(13)(14)(15)(16) …”

Section: Introductionmentioning

confidence: 97%

“…Expression of OCT3/4 has been shown to be useful diagnostic tool in the identification of the more undifferentiated germ cell tumors of the testis, ie. seminoma and embryonal carcinoma(9)(10)(11) 28). This marker has not only been proven valuable for the diagnosis of testicular seminomas but also for establishing germ cell origin in metastatic disease (29, 30).…”

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confidence: 99%