Tertiary volcanism in the Mojave Desert region of southern California followed a long early Tertiary hiatus in volcanism and sedimentation. Volcanism began simultaneously across the region, producing a broad belt of volcanoes that stretched at a high angle to the continental margin from the western tip of the Mojave Desert eastward into Arizona, a distance of more than 500 km. This band of volcanoes was part of a northward-moving wave of volcanism that passed through the southwestern United States in the Tertiary, inland of the migrating Mendocino triple junction. Volcanism coincided (at the temporal resolution of present data) with crustal extension and with the change from subduction to transform-fault tectonics.Although the suite includes rocks ranging from alkali basalt to high-silica rhyolite, petrologic data indicate that volcanism was caused by large-scale injection of the crust by high-alumina basalt magma. Basalt magmas were probably trapped in the crust owing to low crustal density. Intermediate rocks are hybrids produced by mixing of silicic crustal material into mafic magma. Evidence for mixing includes (1) ubiquitous disequilibrium phenocryst textures (e.g., quartz xenocrysts in mafic rocks; reversezoned, spongy plagioclase), and (2) positive correlations of 87 Sr/ 86 Sr and S 18 0 with Si(>2. Major-element, trace-element, and isotopic trends from rocks with <65 weight percent SiC>2 are consistent with a simple mixing model involving addition of rhyolite and minor fractionation of olivine. Above 65 weight percent SiC>2, addition of rhyolite alone can explain observed chemical trends.The tectonic significance of Mojave volcanism remains obscure. The hybrid nature of intermediate rocks and lack of a clear connection to subduction rule out the possibility of using the rocks to make inferences about paleosubduction geometries. The basalt magmas that triggered the volcanic outburst may represent the release, during lithospheric extension, of partial melts of sub-Mojave lithosphere, which was significantly metasomatized by the long period of early Tertiary nonvolcanic subduction.