Magnesium Absorption by Everted Sacs of Rat Intestine and Colon

Aldor, T. A. M.; Moore, Edward W.

doi:10.1016/s0016-5085(19)33684-4

Cited by 28 publications

(6 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to the well-documented process of the absorption of Mg from the rumen of sheep, the intestinal absorption of Mg in ruminants (Phillipson & Storry, 1965;Scott, 1965;Care & van't Klooster, 1965) or in monogastric animals has not been described in detail (Ross, 1961(Ross, , 1962Hendrix, Alcock & Archibald, 1963;Aldor & Moore, 1970;Behar, 1974). Studies using the intestine thus far have failed to demonstrate with certainty the existence of an active mechanism for transport of Mg.…”

Section: Discussionmentioning

confidence: 95%

The Effect of Dinitrophenol on Magnesium Transport Across an Isolated Preparation of Sheep Rumen Epithelium

Martens¹

1985

Exp Physiol

View full text Add to dashboard Cite

SUMMARYMg transport across an isolated preparation of sheep rumen epithelium was studied in vitro. The efflux (flux from the mucosal side to serosal side) and the influx (flux with serosal to mucosal side) were estimated with 28Mg. Under physiological conditions a significant net efflux of Mg was observed, in which the unidirectional efflux was seven to eight times that of the influx. In experiments where ATP synthesis was blocked by the addition of dinitrophenol, Mg efflux was reduced to that of the influx. These observations support the conclusion that Mg absorption across the rumen wall of the sheep is an active process.

show abstract

Section: Discussionmentioning

confidence: 95%

The Effect of Dinitrophenol on Magnesium Transport Across an Isolated Preparation of Sheep Rumen Epithelium

Martens¹

1985

Exp Physiol

View full text Add to dashboard Cite

show abstract

“…Beginning in the 1970s, the interest in magnesium increased following experimental findings that magnesium may exert several effects on the gastrointestinal tract, especially the colon and rectum [54]. Magnesium deficiency is plausibly linked to an increased risk of many types of solid cancers, especially colorectal cancer [55][56][57].…”

Section: Discussionmentioning

confidence: 99%

Nonlinear association between magnesium intake and the risk of colorectal cancer

Jin

Hao

et al. 2013

European Journal of Gastroenterology & Hepatology

View full text Add to dashboard Cite

show abstract

“…Following its development for measurement of sugar absorption (Wilson & Wiseman, 1954), the everted-gut-sac procedure has been validated and used extensively for studies of intestinal uptake of several minerals (Aldor & Moore, 1970;Arduser et al 1985) including Zn (Pearson et al 1966;Seal & Heaton, 1983). In the present study, rates of mucosal: serosal transfer of both glucose and Zn, and tissue accumulation of Zn were reduced by the inclusion of 0.25 mw-ouabain in the incubation medium, indicating the presence of active, energy-demanding, Na+,K+-ATPase-dependent transport mechanisms in the gut preparation used.…”

Section: Discussionmentioning

confidence: 99%

Intestinal zinc transfer by everted gut sacs from rats given diets containing different amounts and types of dietary fibre

Seal

Mathers

1989

Br J Nutr

View full text Add to dashboard Cite

Two experiments were carried out in which rats were offered diets containing different amounts and types of dietary fibre, i.e. commercial stock diet and three semi-purified diets containing no fibre, 200 g wheat bran or 200 g pectin/kg. Dietary inclusion of fibre, and especially pectin, stimulated large bowel fermentation, as indicated by caecal hypertrophy and reduced caecal pH. After 3 weeks, mucosal:serosal zinc transfer and Zn accumulation by tissue were measured using the everted-gut-sac technique. In Expt 2, incubations were carried out in the presence and absence of 0.25 mm-ouabain to assess the importance of transfer by Na+, K+-ATPase-dependent mechanisms, and some observations on glucose transport were also made. Ouabain reduced rates of transfer of both Zn and glucose and also tissue Zn accumulation. There were no significant differences in rates of Zn transfer by everted sacs from duodenal, ileal and colonic sites, but accumulation of Zn by tissue was a more important fate than transfer across the serosal surface, and accumulation by duodenal tissue was approximately twice as great as by other tissues. Mucosal:serosal transfer of glucose by ileal tissue was much more sensitive to ouabain than was Zn transfer. Previous diet appeared to alter the capacity of the intestinal tissue to transfer Zn, with the highest rates of transfer being by colonic tissue from pectin-fed rats.

show abstract

Magnesium Absorption by Everted Sacs of Rat Intestine and Colon

Cited by 28 publications

References 9 publications

The Effect of Dinitrophenol on Magnesium Transport Across an Isolated Preparation of Sheep Rumen Epithelium

The Effect of Dinitrophenol on Magnesium Transport Across an Isolated Preparation of Sheep Rumen Epithelium

Nonlinear association between magnesium intake and the risk of colorectal cancer

Intestinal zinc transfer by everted gut sacs from rats given diets containing different amounts and types of dietary fibre

Contact Info

Product

Resources

About