Magnesium and C-reactive protein in heart failure: an anti-inflammatory effect of magnesium administration?

Almoznino‐Sarafian, Dorit; Berman, Sylvia; Mor, Adi; Shteinshnaider, Miriam; Gorelik, Oleg; Tzur, Irma; Alon, Irena; Modai, David; Cohen, Natan

doi:10.1007/s00394-007-0655-x

Cited by 77 publications

(43 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast to observational studies that linked higher dietary magnesium intakes to lower concentrations of biomarkers of systemic inflammation (8,24), we observed a significant increase in IL-6 concentrations after magnesium treatment. IL-6 is a proinflammatory cytokine secreted by macrophages and T cells and is the major mediator of the acute-phase response (25).…”

Section: Tablecontrasting

confidence: 99%

“…Because elevated IL-6 concentrations may provide an early indicator of acute inflammation, the observed increase in IL-6 concentrations may reflect a variation because of unmeasured underlying acute infection disproportionately present in the magnesium treatment by chance, although we do not have recorded measurements of transitory illness to confirm this explanation. Very few randomized trials have examined the effects of magnesium supplementation on systemic inflammation in overweight individuals (24), and our findings suggest a need for further investigation in larger trials.…”

Section: Tablementioning

confidence: 78%

See 1 more Smart Citation

Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals

Chacko

Sul²,

Song³

et al. 2011

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

Background: Dietary magnesium intake has been favorably associated with reduced risk of metabolic outcomes in observational studies; however, few randomized trials have introduced a systemsbiology approach to explore molecular mechanisms of pleiotropic metabolic actions of magnesium supplementation. Objective: We examined the effects of oral magnesium supplementation on metabolic biomarkers and global genomic and proteomic profiling in overweight individuals. Design: We undertook this randomized, crossover, pilot trial in 14 healthy, overweight volunteers [body mass index (in kg/m 2 ) 25] who were randomly assigned to receive magnesium citrate (500 mg elemental Mg/d) or a placebo for 4 wk with a 1-mo washout period. Fasting blood and urine specimens were collected according to standardized protocols. Biochemical assays were conducted on blood specimens. RNA was extracted and subsequently hybridized with the Human Gene ST 1.0 array (Affymetrix, Santa Clara, CA). Urine proteomic profiling was analyzed with the CM10 ProteinChip array (Bio-Rad Laboratories, Hercules, CA). Results: We observed that magnesium treatment significantly decreased fasting C-peptide concentrations (change: 20.4 ng/mL after magnesium treatment compared with +0.05 ng/mL after placebo treatment; P = 0.004) and appeared to decrease fasting insulin concentrations (change: 22.2 lU/mL after magnesium treatment compared with 0.0 lU/mL after placebo treatment; P = 0.25). No consistent patterns were observed across inflammatory biomarkers. Gene expression profiling revealed up-regulation of 24 genes and down-regulation of 36 genes including genes related to metabolic and inflammatory pathways such as C1q and tumor necrosis factorrelated protein 9 (C1QTNF9) and pro-platelet basic protein (PPBP). Urine proteomic profiling showed significant differences in the expression amounts of several peptides and proteins after treatment. Conclusion: Magnesium supplementation for 4 wk in overweight individuals led to distinct changes in gene expression and proteomic profiling consistent with favorable effects on several metabolic pathways. This trial was registered at clinicaltrials.gov as NCT00737815.

show abstract

Section: Tablecontrasting

confidence: 99%

Section: Tablementioning

confidence: 78%

Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals

Chacko

Sul²,

Song³

et al. 2011

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

show abstract

“…The highest concentrations of magnesium were found in the leaves of Capraria biflora (199 mg/100 g), Mikania glomerata (159 mg/100 g) and Datura stramonium (297 mg/100 g), plants used in folk medicine as an anti-inflammatory. Studies have shown that oral Mg supplementation to heart failure patients significantly reduces blood levels of C-reactive protein, a biomarker of inflammation (Almoznino-Sarafian et al, 2007).…”

Section: Resultsmentioning

confidence: 99%

Characterization of leaves used in infusion preparation grown in northeastern Brazil by chemometric methods based on their multi-elemental composition

et al. 2019

View full text Add to dashboard Cite

On many places of the world, medicinal plants represent the only form of treatment for various diseases. This work aimed to determine and correlate minerals of infusions and leaves of medicinal plants grown in Northeastern Brazil. Principal component and hierarchical cluster analysis and Pearson correlation were performed. The higher content of Na was for Ocimum basilicum L. (94.3 mg/100g) and Datura stramonium L. (91.6 mg/100g). The plants examined had low levels of K in infusions. All samples contain Mg at significant levels. The cluster analysis divided the medicinal plants into three groups, associated with Passiflora edulis, Capraria biflora and Phyllanthus amarus. Ca and Al were the minerals that contributed most to an association between the plants in principal component 1; while K, Na and Mg contributed most in principal component 2. Furthermore, the high percentage of extraction, mainly Ca and Mg, suggests these plants could be used as potential mineral supplements.

show abstract

“…In this publication we discussed amply the role of Se in inflammation. Data concerning Mg and inflammation can be found in the literature [47][48][49][50][51][52][53][54][55][56][57][58][59][60]. The initial invitation of the Editors of this book was indeed to elaborate on these pathophysiological connections.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Sonography in 3D with Emphasis on Perfusion

Moncayo¹,

Moncayo²

2012

Sonography

View full text Add to dashboard Cite

Magnesium and C-reactive protein in heart failure: an anti-inflammatory effect of magnesium administration?

Abstract: Oral Mg supplementation to HF patients significantly attenuates blood levels of CRP, a biomarker of inflammation. Targeting the inflammatory cascade by Mg administration might prove a useful tool for improving the prognosis in HF.

Cited by 77 publications

References 36 publications

Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals

Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals

Characterization of leaves used in infusion preparation grown in northeastern Brazil by chemometric methods based on their multi-elemental composition

Thyroid Sonography in 3D with Emphasis on Perfusion

Contact Info

Product

Resources

About