Magnesium and lymphoma: opportunities in translation

Laecke, Steven Van; Nagler, Evi; Vanholder, Raymond

doi:10.1038/leu.2013.327

Cited by 9 publications

(6 citation statements)

References 21 publications

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“…Patients in the higher magnesium group in our study had only mild hypermagnesemia (1.07‐1.701 mmol/L), which is considered protective in a variety of diseases, including chronic kidney disease and vascular diseases . Low magnesium values are associated with increased oxidative stress, inflammation, and immune impairment . Moreover, magnesium is required to maintain genomic stability and is an essential cofactor in DNA replication and repair .…”

Section: Discussionmentioning

confidence: 99%

“…The rationale for constructing the score is also straight forward. Because relative deficiencies of calcium, magnesium, selenium, zinc, and rubidium are associated with malignancies, patients received one point for any value lower than the specified values in Figure . Relative elevations of copper and iron also receive one point each because they have been associated with malignancies.…”

Section: Methodsmentioning

confidence: 99%

“…Cadmium, lead, arsenic and other toxic metals are established carcinogens . Relative deficiencies of the essential metals calcium, magnesium, selenium, zinc, and rubidium are also associated with malignancies, as are elevations of the essential metals copper and iron …”

Section: Introductionmentioning

confidence: 99%

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A heavy metal baseline score predicts outcome in acute myeloid leukemia

et al. 2020

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Despite abundant epidemiological data linking metals to leukemia and other cancers, baseline values of toxic and essential metals in patients with leukemia and the clinical impact of these metals remain unknown. Thus, we sought to quantify metal values in untreated patients with acute myeloid leukemia (AML) and controls and determine the impact of metal values on AML patients' survival. Serum samples from patients with untreated AML and controls at Hospices Civils de Lyon were analyzed and compared for trace metals and copper isotopic abundance ratios with inductively coupled plasma mass spectrometry. Survival analysis was performed as a function of metal values, and a multi‐metal score was developed for patients with AML. Serum samples were collected from 67 patients with untreated AML and 94 controls. Most patients had intermediate‐risk cytogenetics (63.1%) without FLT3 internal tandem duplication mutations (75.6%) or NPM1 mutations (68.1%). Most metal values differed significantly between AML and control groups. Patients with lower magnesium and higher cadmium values had the worst survival rates, with only 36% surviving at 6 months (P = .001). The adverse prognostic effect of this combination was maintained on multivariate analysis. Based on this, we developed a novel metal score, which accounts for multiple relative abnormalities in the values of five toxic and five essential metals. Patients with a higher metal score had significantly worse survival, which was maintained on multivariate analysis (P = .03). This baseline metal scoring system was also prognostic when we applied it to a separate population of front‐line AML patients.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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A heavy metal baseline score predicts outcome in acute myeloid leukemia

et al. 2020

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“…A role of magnesium in modulating immune response and in lymphomagenesis is increasingly being recognized [2]. Decreased intracellular magnesium causes impaired T-cell and B-cell function, decreased expression of natural killer-activating receptor (NKG2D) in natural killer and T-cells leading to a blunted anti-EBV response, and increased risk of EBV-positive lymphomas [2,3]. Hypomagnesemia was associated with EBV viral load and Burkitt lymphoma in Ugandan women, and associations of EBV with other lymphomas are also documented [4].…”

Section: Dear Editorsmentioning

confidence: 99%

Hypomagnesemia and risk of post‐transplant lymphoproliferative disorder in liver transplant recipients

et al. 2020

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“…Magnesium supplementation in patients with XMEN syndrome led to restoration of the cytotoxic function of these cells and clearance of EBV infection [ 4 ]. In addition, an association of magnesium depletion with the development of non-Hodgkin lymphomas has been reported [ 5 ]. Interestingly, deficiency of magnesium is a common finding following allogeneic HSCT, resulting from metabolic derangements and calcineurin inhibitor–associated renal magnesium wasting [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Magnesium levels and outcome after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia

et al. 2020

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Low intake of magnesium has been associated with the occurrence of lymphomas and decreased magnesium levels suppress the cytotoxic function of T cells and natural killer cells in patients with “X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia” (XMEN) syndrome. These cell types are also important mediators of immune-mediated effects after allogeneic hematopoietic stem cell transplantation. Here, we show that high posttransplant magnesium levels independently associate with a lower incidence of relapse, a higher risk of acute graft-versus-host disease, and a higher non-relapse mortality in 368 patients with acute myeloid leukemia from our center. Magnesium serum levels might impact on donor-cell-mediated immune responses in acute myeloid leukemia.

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Magnesium and lymphoma: opportunities in translation

Cited by 9 publications

References 21 publications

A heavy metal baseline score predicts outcome in acute myeloid leukemia

A heavy metal baseline score predicts outcome in acute myeloid leukemia

Hypomagnesemia and risk of post‐transplant lymphoproliferative disorder in liver transplant recipients

Magnesium levels and outcome after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia

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