Magnesium and the Cardiometabolic Syndrome

Barbagallo, Mario; Domínguez, Ligia J.

doi:10.1007/s13668-012-0010-6

Cited by 9 publications

(5 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, T2DM could contribute to the reduction of serum Mg 2+ levels, and this could, in turn, worsen glycemic control of diabetes. The chronicity of this vicious cycle has been suggested to accelerate the impairment of metabolic control and to predispose to chronic complications of T2DM [36,38,42,43].…”

Section: Discussionmentioning

confidence: 99%

Are Circulating Mg2+ Levels Associated with Glucose Tolerance Profiles and Incident Type 2 Diabetes?

et al. 2019

View full text Add to dashboard Cite

Magnesium (Mg2+) is an enzyme co-factor that plays a key role in many biochemical reactions, as well as in glucose metabolism. Clinical evidences have demonstrated that depletion of serum Mg2+ increases exponentially with the duration of type 2 diabetes mellitus (T2DM). Diabetes is associated with low Mg2+, and hypomagnesemia is associated with insulin resistance, inflammation, and increased risk for cardiovascular disease. In subjects at high risk of inflammation and insulin resistance, supplementation of Mg2+ alone ameliorates both phenotypes, slowing the development and progression of hepatic steatosis. We analyze the relationship between serum Mg2+ levels and the onset of T2DM in a large cohort of well-characterized adult white individuals participating in the CATAMERI study, who were reexamined after a mean follow-up of 5.6 ± 0.9 years. In our analysis we acquired a significant negative correlation between Mg2+ levels, fasting glucose, and 2h-post load glucose in subjects who underwent an OGTT. Moreover, Mg2+ levels correlated negatively with fasting insulin levels, and positively with the lipid profile. As for the detrimental effect of lower circulating Mg2+ levels, our data revealed a significant reduction of T2DM risk of about 20% for each 1 mg/dL increase of circulating Mg2+. The present results are consistent with the theory that Mg2+ supplementation could ameliorate insulin sensitivity reducing the risk to develop T2DM.

show abstract

Section: Discussionmentioning

confidence: 99%

Are Circulating Mg2+ Levels Associated with Glucose Tolerance Profiles and Incident Type 2 Diabetes?

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Over 300 enzymes require the presence of magnesium ions for their catalytic action, including all enzymes utilizing or synthesizing adenosine triphosphate (ATP), or those that use other nucleotides to synthesize deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) . For example, intracellular magnesium deficiency may lead to decreasing tyrosine kinase activity of insulin receptors and to a post‐receptorial impairment in insulin action , which may result in the development of insulin resistance . The magnesium deficiency in cells may also decrease insulin secretion by interacting with cellular calcium homeostasis .…”

Section: Discussionmentioning

confidence: 99%

Magnesium intake decreases Type 2 diabetes risk through the improvement of insulin resistance and inflammation: the Hisayama Study

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Rats fed on a low Mg 2+ diet showed a significant increase of blood glucose and triglycerides. The insulin resistance, observed in the skeletal muscle of rats with MgD is partially associated with a defect of tyrosine kinase activity of the IR [ 86 , 87 , 88 ]. Insulin action begins with the binding of insulin to an IR on the cell membrane of the target cells.…”

Section: Mechanisms Connecting Mgd and Arterial Hypertensionmentioning

confidence: 99%

Role of Magnesium Deficiency in Promoting Atherosclerosis, Endothelial Dysfunction, and Arterial Stiffening as Risk Factors for Hypertension

Kostov

Halacheva

2018

IJMS

152

100

View full text Add to dashboard Cite

Arterial hypertension is a disease with a complex pathogenesis. Despite considerable knowledge about this socially significant disease, the role of magnesium deficiency (MgD) as a risk factor is not fully understood. Magnesium is a natural calcium antagonist. It potentiates the production of local vasodilator mediators (prostacyclin and nitric oxide) and alters vascular responses to a variety of vasoactive substances (endothelin-1, angiotensin II, and catecholamines). MgD stimulates the production of aldosterone and potentiates vascular inflammatory response, while expression/activity of various antioxidant enzymes (glutathione peroxidase, superoxide dismutase, and catalase) and the levels of important antioxidants (vitamin C, vitamin E, and selenium) are decreased. Magnesium balances the effects of catecholamines in acute and chronic stress. MgD may be associated with the development of insulin resistance, hyperglycemia, and changes in lipid metabolism, which enhance atherosclerotic changes and arterial stiffness. Magnesium regulates collagen and elastin turnover in the vascular wall and matrix metalloproteinase activity. Magnesium helps to protect the elastic fibers from calcium deposition and maintains the elasticity of the vessels. Considering the numerous positive effects on a number of mechanisms related to arterial hypertension, consuming a healthy diet that provides the recommended amount of magnesium can be an appropriate strategy for helping control blood pressure.

show abstract

Magnesium and the Cardiometabolic Syndrome

Cited by 9 publications

References 86 publications

Are Circulating Mg2+ Levels Associated with Glucose Tolerance Profiles and Incident Type 2 Diabetes?

Are Circulating Mg2+ Levels Associated with Glucose Tolerance Profiles and Incident Type 2 Diabetes?

Magnesium intake decreases Type 2 diabetes risk through the improvement of insulin resistance and inflammation: the Hisayama Study

Role of Magnesium Deficiency in Promoting Atherosclerosis, Endothelial Dysfunction, and Arterial Stiffening as Risk Factors for Hypertension

Contact Info

Product

Resources

About