Magnesium deficiency and febrile seizure: A systematic review and meta‐analysis

Ataei‐Nakhaei, Alireza; Rouhani, Zahra‐Sadat; Bakhtiari, Elham

doi:10.1111/ncn3.12410

Cited by 4 publications

(2 citation statements)

References 30 publications

(53 reference statements)

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“…There are several limitations in the interpretation of some of the findings. This includes the evaluation of risk related to micronutrient deficiencies 23 , of which only iron deficiency has been evaluated in this study. Due to logistical limitations, we were not able to test for any other elements such as zinc, magnesium and calcium, previously suggested to play a possible role in the pathogenesis of FS.…”

Section: Characteristicmentioning

confidence: 99%

Risk factors for development of febrile seizures in children admitted to Lady Ridgeway Hospital, Sri Lanka

Wanigasinghe¹,

Silva²,

Dassanayake³

et al. 2022

Sri Lanka J. Neurology

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Background: Febrile seizures (FS) are reported more frequently in the Asian population. Identifying risk factors for the development of FS, would enable parents and health care providers to avoid any preventable factors. There is no data on risk factors for developing febrile seizures in Sri Lankan children.Methods: An unmatched case-control study was performed at the premier children's hospital in the country over a 6-month period. Children aged 6 months to 6 years, who presented with FS (first ever or recurrence), confirmed by a paediatrician, were recruited for the study. The controls were children presenting with a febrile illness not complicated with seizures. History and examination were used to identify any underlying neurological disorder or developmental delay. Interviewer-administered questionnaire, clinic records and haematological investigations were used for risk factor evaluation. Risk of potential variables was assessed by calculating the odds ratio (OR).Results: There were 74 cases and 67 controls. Their corresponding median ages were 28 (IQR 16) and 36 (IQR 48) months. Among cases, 62% presented with simple FS and all others with complex febrile seizures; 5.4% presented in status epilepticus. Thirty-four (50%) presented with their first ever seizure; in the balance it was a recurrence.It was only the family history of febrile seizures (OR=6.27) and low axillary temperature at time of seizure (OR=2.21) that were found to be associated with a significant risk of development of febrile seizures in our patients. Conclusion:This study described the demographics of FS and identified the risk factors for development of FS in Sri Lankan children.

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Section: Characteristicmentioning

confidence: 99%

Risk factors for development of febrile seizures in children admitted to Lady Ridgeway Hospital, Sri Lanka

Wanigasinghe¹,

Silva²,

Dassanayake³

et al. 2022

Sri Lanka J. Neurology

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“…Although FS often have good prognoses, their occurrence is a worrisome predicament for parents of the affected children as about 2–8% eventually develop epilepsy in the future [13] , [14] . A recent meta-analysis [15] summarized hypomagnesemia in children with FS, however, subsequent studies are still inconsistent [16] . In this study, we compared the levels of serum magnesium between children with febrile seizures and those who were febrile but had no seizures, to ascertain the hypothesized association between serum magnesium and febrile seizures.…”

Section: Introductionmentioning

confidence: 99%

Serum hypomagnesemia is associated with febrile seizures in young children

Mohamed

Tang

Thokerunga

et al. 2022

AIMSN

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<abstract><sec> <title>Background</title> Febrile seizures (FS) frequently manifest in children below 5 years of age. Although the exact etiology is still unknown, genetic predisposition, changes in neurotransmitter levels, and serum electrolyte imbalance are some of the known risk factors. This study examined the possible association between serum magnesium levels in children with FS compared to febrile children without seizures. </sec><sec> <title>Methods</title> A retrospective case-control study was conducted from February 2019 to January 2021, recruiting 230 age and gender-matched cases and controls (115 each). Extracted data were analyzed using SPSS using an independent student's t-test, Chi-square test, and Pearson's correlation analysis. </sec><sec> <title>Results</title> The mean serum magnesium levels were 0.93 ± 0.129 vs 0.97 ± 0.0961; p < 0.001, between cases and controls respectively. Similarly, hypomagnesemia (<0.85 mmol/L) was detected in 26.1% and 8.7% of the cases and controls, respectively; p < 0.001. A significant negative correlation was found between serum magnesium levels and the occurrence of febrile seizures; r = [−0.169], p < 0.05. </sec><sec> <title>Conclusion</title> Serum magnesium was significantly low in febrile children with seizures compared to those without, and hypomagnesemia was associated with the occurrence of febrile seizures. These results portray hypomagnesemia as a possible risk factor for febrile seizure, and so should be validated in future large cohort studies so that guidelines are set for proper management of these children. </sec></abstract>

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