Magnesium degradation under physiological conditions – Best practice

González, Jorge Alfonso Murillo; Hou, Ruiqing; Nidadavolu, Eshwara Phani Shubhakar; Willumeit‐Römer, Regine; Feyerabend, Frank

doi:10.1016/j.bioactmat.2018.01.003

Cited by 202 publications

(155 citation statements)

References 125 publications

(132 reference statements)

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“…The main intermediate product deposits on the surface of Mg‐based metals are: Mg(OH) 2 , MgCO 3 , Mg 3 (PO 4 ) 2 , CaCO 3 , and Ca 3 (PO 4 ) 2. 31,32 In situ observation demonstrates that these deposits can be phagocytosed by macrophages 33. Furthermore, synchrotron microbeam X‐ray fluorescence (μXRF) mapping demonstrates that the Mg ions released from the degradation of the intermediate products are temporarily stored in the bone matrix,34 partially contributing to the fate of the released Mg ions.…”

Section: Advantages Of Mg‐based Metals For Orthopedic Applicationsmentioning

confidence: 99%

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Biodegradable Magnesium‐Based Implants in Orthopedics—A General Review and Perspectives

et al. 2020

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Biodegradable Mg‐based metals may be promising orthopedic implants for treating challenging bone diseases, attributed to their desirable mechanical and osteopromotive properties. This Review summarizes the current status and future research trends for Mg‐based orthopedic implants. First, the properties between Mg‐based implants and traditional orthopedic implants are compared on the following aspects: in vitro and in vivo degradation mechanisms of Mg‐based implants, peri‐implant bone responses, the fate of the degradation products, and the cellular and molecular mechanisms underlying the beneficial effects of Mg ions on osteogenesis. Then, the preclinical studies conducted at the low weight bearing sites of animals are introduced. The innovative strategies (for example, via designing Mg‐containing hybrid systems) are discussed to address the limitations of Mg‐based metals prior to their clinical applications at weight‐bearing sites. Finally, the available clinical studies are summarized and the challenges and perspectives of Mg‐based orthopedic implants are discussed. Taken together, the progress made on the development of Mg‐based implants in basic, translational, and clinical research has laid down a foundation for developing a new era in the treatment of challenging and prevalent bone diseases.

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Section: Advantages Of Mg‐based Metals For Orthopedic Applicationsmentioning

confidence: 99%

“…A) Degradation behaviour of Mg‐based orthopaedic implants and the corrosion products of Mg‐based orthopaedic devices under physiological conditions. Adapted with permission 32. Copyright 2018, Elsevier.…”

Section: Advantages Of Mg‐based Metals For Orthopedic Applicationsmentioning

confidence: 99%

Biodegradable Magnesium‐Based Implants in Orthopedics—A General Review and Perspectives

et al. 2020

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“…The corrosion behavior of Mg alloys differs when different simulated body fluids are used due to the different compositions of the fluids and different corrosion products formed. In particular, the use and type of buffering agent plays a particularly significant role in determining the type of corrosion product formed [9,156]. For example, the corrosion resistance of ZK60 alloy in Hanks' solution is higher than in DMEM and DMEM + fetal bovine serum (FBS).…”

Section: Influence Of Environment On the Corrosion Behaviormentioning

confidence: 99%

The Corrosion Performance and Mechanical Properties of Mg-Zn Based Alloys—A Review

Jiang

Blawert

Zheludkevich

2020

CMD

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Magnesium alloys have shown great potential for applications as both structural and biomedical materials due to their high strength-to-weight ratio and good biodegradability and biocompatibility, respectively. Among them, Mg-Zn based alloys are attracting increasing interest for both applications. As such, this article provides a review of the corrosion performance and mechanical properties of Mg-Zn based alloys, including the influence of environment and processing on both of them. The strategies for tailoring corrosion resistance and/or mechanical properties by microstructure adjustment and surface treatment are discussed.

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“…The corrosion rates for Mg may differ depending on various parameters: the degree of its purity, heat treatment of the material, the type of electrolyte, the time of immersion, the crystal orientation, etc. [6,7,17,[26][27][28][29][30][31]. As reported, Mg in the high-purity form has the lowest corrosion rate, below 1 mlcm −2 day −1 .…”

Section: Evolution Of the Corrosion Reaction With Timementioning

confidence: 60%

“…; n is 1 or 2, depending on the phosphate type. The second term is a generic form of (mono, di, tri) magnesium phosphate hydrate, while the third term is magnesium hydroxide, which is an expected product of the Mg alloy corrosion in SBF [29]. Magnesium phosphate is indicated by the ratio of the calcium concentration to the phosphorus concentration, being significantly lower than 1.66, which corresponds to the apatite (Table 4).…”

Section: Xps Of Samples After Sbf Immersionmentioning

confidence: 99%

Surface Analysis of Biodegradable Mg-Alloys after Immersion in Simulated Body Fluid

et al. 2020

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Two binary biodegradable Mg-alloys and one ternary biodegradable Mg-alloy (Mg-0.3Ca, Mg-5Zn and Mg-5Zn-0.3Ca, all in wt%) were investigated. Surface-sensitive X-ray photoelectron spectroscopy analyses (XPS) of the alloy surfaces before and after immersion in simulated body fluid (SBF) were performed. The XPS analysis of the samples before the immersion in SBF revealed that the top layer of the alloy might have a non-homogeneous composition relative to the bulk. Degradation during the SBF immersion testing was monitored by measuring the evolution of H2. It was possible to evaluate the thickness of the sample degradation layers after the SBF immersion based on scanning electron microscopy (SEM) of the tilted sample. The thickness was in the order of 10–100 µm. The typical bio-corrosion products of all of the investigated alloys consisted of Mg, Ca, P and O, which suggests the formation of apatite (calcium phosphate hydroxide), magnesium hydrogen phosphate hydrate and magnesium hydroxide. The bioapplicability of the analyzed alloys with regard to surface composition and degradation kinetics is discussed.

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Magnesium degradation under physiological conditions – Best practice

Cited by 202 publications

References 125 publications

Biodegradable Magnesium‐Based Implants in Orthopedics—A General Review and Perspectives

Biodegradable Magnesium‐Based Implants in Orthopedics—A General Review and Perspectives

The Corrosion Performance and Mechanical Properties of Mg-Zn Based Alloys—A Review

Surface Analysis of Biodegradable Mg-Alloys after Immersion in Simulated Body Fluid

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