Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory

Wu, Yanhua; Funato, Yosuke; Meschi, Eleonora; Jovanoski, Kristijan D; Miki, Hiroaki; Waddell, Scott

doi:10.7554/elife.61339

Cited by 10 publications

(11 citation statements)

References 155 publications

(225 reference statements)

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“…Recently, two studies in flies have implicated the CNNM ortholog, UEX, in brain development and function [24,62]. Normal and enhanced fly memory requires the expression of UEX, and regulated neuronal Mg 2+ efflux is critical for normal and Mg 2+enhanced memory [62].…”

Section: Schizophreniamentioning

confidence: 99%

New insights into the structure and function of CNNM proteins

Chen

Gehring

2023

The FEBS Journal

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Magnesium (Mg2+) is the most abundant divalent cation in cells and plays key roles in almost all biological processes. CBS‐pair domain divalent metal cation transport mediators (CNNMs) are a newly characterized class of Mg2+ transporters present throughout biology. Originally discovered in bacteria, there are four CNNM proteins in humans, which are involved in divalent cation transport, genetic diseases, and cancer. Eukaryotic CNNMs are composed of four domains: an extracellular domain, a transmembrane domain, a cystathionine‐β‐synthase (CBS)‐pair domain, and a cyclic nucleotide‐binding homology domain. The transmembrane and CBS‐pair core are the defining features of CNNM proteins with over 20 000 protein sequences known from over 8000 species. Here, we review the structural and functional studies of eukaryotic and prokaryotic CNNMs that underlie our understanding of their regulation and mechanism of ion transport. Recent structures of prokaryotic CNNMs confirm the transmembrane domain mediates ion transport with the CBS‐pair domain likely playing a regulatory role through binding divalent cations. Studies of mammalian CNNMs have identified new binding partners. These advances are driving progress in understanding this deeply conserved and widespread family of ion transporters.

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Section: Schizophreniamentioning

confidence: 99%

New insights into the structure and function of CNNM proteins

Chen

Gehring

2023

The FEBS Journal

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“…Calcium (Ca) and magnesium (Mg) enable muscle contraction-relaxation and participate in intracellular communication and ATP metabolism, respectively [21]. In Drosophila, Ca is required for egg activation [26] and dietary Mg improves memory function [27]. Iron (Fe) is a component of several metalloenzymes involved in toxin degradation via cytochrome P450, moulting hormone production [28], innate immune response [29][30][31], magnetoreception in bees [32], fecundity in mosquitoes [33] and neurodevelopment in mammals [34].…”

Section: Introductionmentioning

confidence: 99%

Behavioural regulation of mineral salt intake in honeybees: a self-selection approach

Sousa

Darnell

Wright

2022

Phil. Trans. R. Soc. B

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Minerals are required in small amounts to sustain metabolic activity in animals, but mineral deficiencies can also lead to metabolic bottlenecks and mineral excesses can induce toxicity. For these reasons, we could reasonably expect that micronutrients are actively regulated around nutritional optima. Honeybees have co-evolved with flowering plants such that their main sources of nutrients are floral pollen and nectar. Like other insects, honeybees balance their intake of multiple macronutrients during food consumption using a combination of pre- and post-ingestive mechanisms. How they regulate their intake of micronutrients using these mechanisms has rarely been studied. Using two-choice feeding assays, we tested whether caged and broodless young workers preferred solutions containing individual salts (NaCl, KCl, CaCl 2 , MgCl 2 ) or metals (FeCl 3 , CuCl 2 , ZnCl 2 , MnCl 2 ) in a concentration-dependent manner. We found that young adult workers could only self-select and optimize their dietary intake around specific concentrations of sodium, iron and copper. Bees largely avoided high concentration mineral solutions to minimize toxicity. These experiments demonstrate the limits of the regulation of intake of micronutrients in honeybees. This is the first study to compare this form of behaviour in one organism for eight different micronutrients. This article is part of the theme issue ‘Natural processes influencing pollinator health: from chemistry to landscapes’.

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“…In flies, the single PRL isoform was shown to play roles in the nervous system, directing synaptogenesis and protecting against CO 2 -dependent overstimulation, as well as wing vein development ( 35 , 39 , 40 ). The fly CNNM homolog, encoded by the unextended ( uex ) gene, has been implicated in long-term memory development and circadian rhythms ( 41 , 42 ). In nematodes, PRL was shown to be required for proper trafficking of lysosomal proteins ( 43 ).…”

Section: Discussionmentioning

confidence: 99%