Magnesium in Women’s Health and Gynecology

Tonick, Shawna; Muneyyirci-Delale, Ozgul

doi:10.4236/ojog.2016.65041

Cited by 9 publications

(6 citation statements)

References 53 publications

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“…Vitamins C and E have antioxidant properties that stabilize cell membranes and prevent DNA damage and consequent mutations as a result of oxidative stress. Magnesium, calcium, and phosphorus function as co-factors in the synthesis and repair of DNA and regulation of hormones [ 14 ]. Ciebiera et al found elevated levels of alpha-tocopherol in women with uterine fibroid and concluded that vitamin E as a phytoestrogen may modulate estrogen receptors and increase oestrogen levels, thereby increasing the odds of developing uterine fibroids [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Micronutrient and Trace Element Levels in Serum of Women With Uterine Fibroids in Lagos

Makwe¹,

Soibi‐Harry²,

Rimi³

et al. 2021

Cureus

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Background: Uterine fibroids significantly affect the quality of life of reproductive-age women. The socioeconomic cost and psychological strain on patients cannot be overemphasized. The role of diet and micronutrients on the onset and development of uterine fibroids has come under review in recent times. This study assessed the levels of some micronutrients and trace elements in the serum of women with uterine fibroids.Methods: Eighty-eight women were recruited from the Gynecology Outpatient Clinic of Lagos University Teaching Hospital, 44 with uterine fibroids and 44 women without uterine fibroids. Blood samples were obtained and analyzed for serum levels of selected micronutrients (vitamins A, C, D, and E) and trace elements (calcium, magnesium, and phosphorus). Pelvic ultrasonography was performed on all study participants.Results: Women with uterine fibroids had statistically significant lower serum levels of vitamin C (1.20 ± 0.59 vs 1.62 ± 1.75 mg/dl; p = 0.01), vitamin D (34.23 ±10.67 vs 37.06 ±11.46 ng/ml; p = 0.04), and calcium (2.27 ± 0.19 vs 2.32 ± 0.09 mmol/L; p = 0.02) compared with women without uterine fibroids. There was no significant difference in the serum levels of vitamins A (39.63 ± 15.71 vs 40.09 ±15.26 μ/dl; p = 0.91), vitamin E (5.44 ± 4.65 vs 5.26 ± 4.62 µg/mL; p = 0.87), magnesium (0.89 ± 0.09 vs 0.89 ± 0.08 mmol/L; p = 0.78), and phosphorus (1.29 ± 0.38 vs 1.19 ± 0.17 mmol/L; p = 0.14) in women with uterine fibroids compared to those without uterine fibroids.Conclusion: This study showed lower serum levels of vitamin C, vitamin D, and calcium in women with uterine fibroids when compared to women without uterine fibroids. It is possible that these micronutrients and trace elements may play a role in the etiopathogenesis, progression, and/or proliferation of uterine fibroids. However, whether the findings of low serum levels of these elements are a cause or an effect of uterine fibroid, is yet to be determined.

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Section: Introductionmentioning

confidence: 99%

Micronutrient and Trace Element Levels in Serum of Women With Uterine Fibroids in Lagos

Makwe¹,

Soibi‐Harry²,

Rimi³

et al. 2021

Cureus

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“…These results in the immune response followed by inflammatory cascades [ 155 ]. Hypomagnesemia contributes to oxidative stress and inflammation and is inversely related to CRP [ 156 ]. An average adult human body contains about 24 g or 1000 mmol of Mg, of which 99% is stored, and 1% is available extracellularly in serum and red blood cells (RBC) [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Magnesium Status and Ca/Mg Ratios in a Series of Children and Adolescents with Chronic Diseases

et al. 2022

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Magnesium (Mg) is an essential divalent cation involved in various enzymatic reactions that regulate vital biological functions. The main goal was to evaluate Mg status and its association with nutritional indicators in 78 children and adolescents with chronic diseases. We assessed anthropometric, biochemical, diet, body composition, and bone densitometry valuations. Serum Mg and Ca levels were determined using the standardized method and diet calcium (Ca) and Mg consumption by a prospective 72 h diet survey. Mean serum Ca (9.9 mg/dL), Mg (2.08 mg/dL) dietary Ca (102% DRI: Dietary Reference Intake), and Mg intake (105% DRI) were normal. A total of 45% had hypomagnesemia, 12% had hypermagnesemia, and 26% and 24% had inadequate and high Mg intake, respectively. Only 6% of patients had poor Mg intake and hypomagnesemia, and 54% and 90% of our series had an elevated serum Ca/Mg ratio > 4.70 (mean 4.79) and a low Ca/Mg intake ratio < 1.70 (mean 1.06), respectively. Both Ca/Mg ratios were linked with the risk of developing other chronic conditions such as cardiovascular disease, type 2 diabetes, syndrome metabolic, and even several cancers. Therefore, 79% of children and adolescents with chronic diseases were at elevated risk of having abnormal Mg status and developing other chronic illnesses.

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“…The high prevalence of HME in the Russian Federation could possibly be explained by an unbalanced diet, the consumption of types of food that increase Mg requirement (such as soft drinks containing phosphoric acid), and an overall decline in the micronutrient density of foods 22 . Calcium (Ca) and Mg levels are closely related, both vary consistently throughout the menstrual cycle and women are sensitive to these variations 7 . Additionally, specific conditions, such as pregnancy, may lead to changes in the need for Mg.…”

Section: Discussionmentioning

confidence: 99%

“…Common causes of Mg deficiency include inadequate dietary intake or gastrointestinal absorption, loss through the gastrointestinal or renal system, and pregnancy, where there is an increased requirement for Mg 6 . Mg deficiency is more frequent in women than men and specific Mg functions in women’s health are well recognized 6 , like premenstrual syndrome, osteoporosis, cancer and menopause 7 .…”

Section: Introductionmentioning

confidence: 99%

Magnesium level correlation with clinical status and quality of life in women with hormone related conditions and pregnancy based on real world data

Orlova

Dikke²,

Pickering

et al. 2021

Sci Rep

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This study was aimed to assess the effectiveness of magnesium (Mg)-vitamin B 6 replenishment and its correlation with clinical status in pregnant women (PW), and quality of life in women with hormone-related conditions (HRCW) and hypomagnesemia (HME). Data collected in four observational studies were pooled and analysed. All women received Mg supplementation for 4 weeks. The proportion of women with normalized Mg level, and the correlation between serum Mg dynamics and number of symptoms/complaints (PW) or changes in World Health Organization quality of life questionnaire scores (WHOQOL; HRCW) were evaluated. 869 PW and 957 HRCW were included in the study. Normalization of serum Mg level to ≥ 0.66 mmol/L occurred in 92.1% of PW and 78.4% of HRCW, and to ≥ 0.8 mmol/L in 73.8% and 58.9%, respectively. Mg normalization was accompanied by a median decrease of 1 symptom and 1 complaint in PW. Serum Mg level increase by 0.1 mmol/L was associated to significant changes in the WHOQOL scores in HRCW. Treatment of HME with the Mg for approximately 4 weeks provided a high response rate of Mg serum level, was associated with an improvement in symptom severity and complaints in PW, and WHOQOL score in HRCW. A 0.8 mmol/L cut-off appeared to be more relevant in terms of patient-reported outcomes.

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Magnesium in Women’s Health and Gynecology

Cited by 9 publications

References 53 publications

Micronutrient and Trace Element Levels in Serum of Women With Uterine Fibroids in Lagos

Micronutrient and Trace Element Levels in Serum of Women With Uterine Fibroids in Lagos

Magnesium Status and Ca/Mg Ratios in a Series of Children and Adolescents with Chronic Diseases

Magnesium level correlation with clinical status and quality of life in women with hormone related conditions and pregnancy based on real world data

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