Magnesium levels in serum and in C.S.F. in febrile convulsions in infants and children

Chhaparwal, B. C.; Kohli, G. S.; Pohowalla, J. N.; Singh, S. D.

doi:10.1007/bf02823660

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…Mg have contributing effect in the incidence of febrile convulsion. [5][6][7][8] Limited data is available on the levels of serum magnesium in children with febrile convulsions. Therefore a study was planned to estimate the levels of serum magnesium and establish the correlation between serum levels of magnesium in children with febrile convulsions.…”

Section: Studies Done By Chhaparwal Et Al Mishra Et Al Ahmad Et Al mentioning

confidence: 99%

“…9,12 Chhaparwal et al determined Mg levels in the serum and in the CSF in 100 Indian children presenting with febrile convulsions and found out that children with febrile convulsions had low serum and CSF concentrations of magnesium and stated that there are certain biochemical changes that occur during the febrile state which possibly precipitate febrile convulsions. 5 In a study by Mishra et al levels of Mg and other elements were evaluated in CSF in Indian children with febrile seizure. The study subjects included 20 cases of febrile convulsion, 26 patients of encephalitis and 22 children of fever with meningismus.…”

Section: Serum Magnesiummentioning

confidence: 99%

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Correlation of serum magnesium levels in febrile convulsions in children: a cross sectional comparative study

Addlur

Khandelwal

Mangajjera

et al. 2021

Int J Contemp Pediatr

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Background: Febrile convulsions is one of the most common type of seizures seen in children. It has been suggested that low serum magnesium (Mg) has occasionally been associated with epilepsy. A positive correlation of the hypomagnesemia with the severity of epilepsy was also found. The present study aimed to estimate the levels of serum magnesium in children with febrile convulsions and to compare serum magnesium levels with normal children.Methods: Fifty patients who were eligible after screening for inclusion and exclusion criteria were included in the study group after a signed written informed consent and 50 controls were also taken. A detailed history, clinical examination and these investigations were done – complete blood count (CBC) (Hb, DC and ESR), serum calcium, serum magnesium, serum electrolytes, random blood sugar and cerebrospinal fluid (CSF) analysis.Results: The serum magnesium level was normal in 45 patients (90%) with febrile convulsions, low levels in 4 cases (8%) and high levels seen in 1 case (2%). Serum magnesium levels were normal in all 50 controls. In this study, the serum magnesium levels has got no correlation in patients with febrile convulsion. So, routine magnesium supplementation need not be prescribed in normal subjects to prevent febrile convulsions.Conclusions: Routine measurement of serum levels of Mg, glucose and calcium are warranted in subject with febrile convulsions. However, large prospective studies are further required in future to establish the correlation of serum Mg and febrile convulsions so that a standard guidelines can be set up which could be followed universally.

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Section: Studies Done By Chhaparwal Et Al Mishra Et Al Ahmad Et Al mentioning

confidence: 99%

Section: Serum Magnesiummentioning

confidence: 99%

Correlation of serum magnesium levels in febrile convulsions in children: a cross sectional comparative study

Addlur

Khandelwal

Mangajjera

et al. 2021

Int J Contemp Pediatr

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“…Magnesium plays an important role in establishing electrical potential across cell membrane. It also affects calcium metabolism as the production of cyclic adenosine monophosphate is magnesium dependent which in turn controls release of parathyroid hormone 19,20,21 . In clinical practice, hypomagnesemia is underdiagnosed or incorrectly measured in patients with febrile seizure.…”

Section: Operational Definition Febrile Seizures (Fs)mentioning

confidence: 99%

Association of Serum Calcium and Magnesium Level with Febrile Seizure

Sarker

Islam

Pal

et al. 2022

Sir Salimullah Med. Coll. J.

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Background: Febrile seizures occur in 2 to 5% of all children with a recurrence rate of 30 to 40%. Calcium and magnesium is closely related to pathophysiology of seizures and aim of this study was to find out the association of serum calcium and magnesium level with febrile seizure. Methods: A cross sectional analytical study was conducted among One hundred (100) subjects of both sexes with age range 6 months to 60 months in department of pediatrics from June 2019 to May 2020. The subjects were grouped into case (group A) and control (group B) by purposive sampling who were seeking fever with convulsion (group A) and fever without convulsion (group B). Statistical analyses were performed by Chi-square test and/or Fisher’s exact test as applicable for comparing qualitative variables and for quantitative variables using unpaired t-test and/or Mann-Whitney U test for comparing between the groups. Pearson’s Correlation Coefficient test was done to observe the correlation between low calcium and Magnesium level in febrile seizure. A p-value of <0.05 was considered as significant for all analytical tests. Results: Hypocalcaemia were more in 25-36 months of age and hypomagnesaemia 37-48 months in febrile seizure Hypomagnesaemia were more in patients who had previous febrile seizure (1.89 ± 0.73 mg/dl, p- value 0.045). Association and positive correlation were found between serum calcium and serum magnesium with febrile seizure. Multivariate logistic regression showed hypocalcaemia and hypomagnesaemia are independent risk factor for febrile seizures where hypocalcaemia OR=2.144 and hypomagnesaemia OR 1.2. Conclusion: Association and positive correlation were found between serum calcium and serum magnesium with febrile seizure and more in recurrent febrile seizure. Sir Salimullah Med Coll J 2022; 30: 14-22

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“…6 In adults, calcitoninlike immunoreactive material has been reported in the CSF78; on column chromatography, the CSF immunoreactive calcitonin co-eluted with radioiodinated human calcitonin, confirming the presence of calcitonin.8 In recent reports, a possible neuroregulatory role for calcitonin has been suggested; intracerebral injection of calcitonin results in inhibition of eating patterns in rats,9 inhibition of gastric acid secretion,10 and potent analgesic effect in the mouse.11 However, no information on CSF levels of calcitonin in children is available. In adults, CSF levels of calcium and phosphorus are low: CSF calcium is 44% of the serum calcium concentration,8 and the CSF phosphorus content is 38% of the serum phosphorus concentration.4 In adults who underwent routine diagnostic lumbar puncture for suspected prolapse of a'vertebral disk, CSF concentrations of magnesium were higher than serum concentrations of this element,6 and similar findings were noted in children with typhoid encephalopathy and tuberculous meningitis.…”

mentioning

confidence: 99%

Calcium, Phosphorus, Magnesium, and Calcitonin Concentrations in the Serum and Cerebrospinal Fluid of Children

Venkataraman¹,

Kirk²,

Tsang³

et al. 1987

Arch Pediatr Adolesc Med

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Magnesium levels in serum and in C.S.F. in febrile convulsions in infants and children

Cited by 6 publications

References 12 publications

Correlation of serum magnesium levels in febrile convulsions in children: a cross sectional comparative study

Correlation of serum magnesium levels in febrile convulsions in children: a cross sectional comparative study

Association of Serum Calcium and Magnesium Level with Febrile Seizure

Calcium, Phosphorus, Magnesium, and Calcitonin Concentrations in the Serum and Cerebrospinal Fluid of Children

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