Magnesium Metabolism in Patients on Regular Dialysis Treatment

The Mg, Ca and immunoreactive parathyroid hormone (PTH) serum levels were determined in 22 uremic patients on chronic hemodialysis with different Mg concentrations in the dialysate. Baseline levels of PTH, Ca and Mg were obtained over a 4-month-period whilst on Mg dialysis of 1.5 mEq/l. Patients were then divided into three groups: 10 patients were dialyzed for 6 months with 0.5 mEq/l of Mg, 7 patients with 1.5 mEq/l, and 5 patients with 2.5 mEq/l Mg. At the end of the 6-month period with differentiated Mg dialysis the three groups were characterized by significantly different Mg serum levels. On the contrary, no significant changes were observed in the PTH or the Ca serum levels. The results of this study indicate that PTH secretion in uremic patients on regular hemodialysis is not appreciably influenced by the Mg serum levels.

Section: Discussionsupporting

confidence: 77%

On the Effect of Magnesium on the PTH Secretion in Uremic Patients on Maintenance Hemodialysis

Gonella¹,

Bonaguidi²,

Buzzigoli³

et al. 1981

“…The presence of high plasma Mg levels in patients on maintenance hemodialysis is a well-known fact [4,6,[11][12][13], confirmed in the present study. Previous authors found higher erythrocyte Mg concentration in patients treated by regular hemodialysis than in healthy persons [1][2][3][4][5][6].…”

Section: Discussionsupporting

confidence: 78%

The Relationship between Hematocrit and Erythrocyte Magnesium Concentration in Patients on Regular Hemodialysis

Gonella¹,

Betti²,

Buzzigoli³

et al. 1979

Plasma and erythrocyte magnesium (Mg) concentrations were measured in uremics on regular hemodialysis, in healthy persons and in patients with anemia due to causes other than renal failure. The mean plasma Mg concentration was found to be significantly higher in the uremic patients than in other subjects. The erythrocyte Mg concentration in anemic uremics and in nonuremic anemics was found to be higher than in normal subjects and a close inverse relationship was found between this figure and the hematocrit. It seems reasonable to argue that anemia, rather than renal failure, is related to the high concentration of Mg in erythrocytes.

“…However, in accordance with other authors [9,21] the magnesium content of the erythrocytes is expressed uncorrected as the 'erythrocyte magnesium content'. The results reported in this paper from healthy subjects correspond with previously reported values [9], Organ volume was chosen as the reference standard for the bone analysis.…”

Section: Discussionmentioning

confidence: 96%

The Effect of Low Magnesium Dialysate on Plasma, Ultrafiltrable, Erythrocyte and Bone Magnesium Concentrations from Patients on Maintenance Haemodialysis

Catto¹,

Reid²,

MacLeod³

1974

Dialysis fluid containing a low concentration of magnesium ( ≤ 0.05 mmol/l) was used to treat 17 patients on maintenance haemodialysis for varying periods of time up to 5 years. Mean plasma and ultrafiltrable magnesium concentrations measured in these patients before haemodialysis did not differ significantly from control values; after dialysis, plasma and ultrafiltrable magnesium concentrations were reduced only temporarily. Erythrocyte magnesium concentrations were elevated both before and after haemodialysis: dialysis did not significantly alter the mean concentrations. There was no significant correlation between the length of time on maintenance haemodialysis and either plasma or erythrocyte magnesium levels. As the mean magnesium concentration of bone biopsy specimens was also significantly greater than the mean from the control subjects, there was no evidence that magnesium depletion had been produced in these dialysis patients.