Magnesium (Mg2 +), Strontium (Sr2 +), and Zinc (Zn2 +) Co-substituted Bone Cements Based on Nano-hydroxyapatite/Monetite for Bone Regeneration

Dias, Alexa Magalhães; Canhas, Isabela do Nascimento; Bruziquesi, Carlos Giovani Oliveira; Speziali, Marcelo Gomes; Sinisterra, Rubén D.; Cortés, María Esperanza

doi:10.1007/s12011-022-03382-5

Cited by 12 publications

(3 citation statements)

References 94 publications

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“…nHA shares structural and biochemical similarities with the mineral composition of animal and human bone tissues and is considered an ideal material for bone defect healing due to its exceptional biocompatibility, osteoconductivity, osteoinductivity, and bioactivity. − Recent studies showed that incorporating metal ions into nHA can significantly improve the mechanical, biological, and antimicrobial characteristics. Various metal ions, such as Y 3+ , Zn 2+ , Mn 2+ , Mg 2+ , Sr 2+ , Ti 4+ , or Ag 2+ , have been doped into nHA to enhance the physicochemical attributes; − the selected dopant must improve the physicochemical properties of nHA without compromising its biological efficacy . Among these, Sr 2+ , a trace element in human bone tissue, is known for its osteoinductive properties, biocompatibility, and relevance in treating osteoporosis. , The biological prowess of Sr 2+ has increased the focus on developing strontium-nanohydroxyapatite (Sr-nHA) in recent years.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Carboxymethyl Chitosan/Sodium Alginate Composite Hydrogel Scaffolds Carrying Chlorhexidine and Strontium-Doped Hydroxyapatite

Liu,

Li,

et al. 2024

ACS Omega

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Herein, we introduce a novel composite hydrogel scaffold designed for addressing infectious jaw defects, a significant challenge in clinical settings caused by the inherent limited selfregenerative capacity of bone tissues. The scaffold was engineered from a blend of carboxymethyl chitosan (CMCS)/sodium alginate (SA) hydrogel (CSH), β-cyclodextrin/chlorhexidine clathrate (β-CD-CHX), and strontium-nanohydroxyapatite nanoparticles (Sr-nHA). The β-CD-CHX and Sr-nHA components were synthesized using a saturated aqueous solution and a coprecipitation method, respectively. Subsequently, these elements were encapsulated within the CSH matrix. Comprehensive characterization of the CMCS/SA/β-CD-CHX/Sr-nHA composite hydrogel scaffold via scanning electron microscopy, X-ray photoelectron spectroscopy, and Fourier-transform infrared spectroscopy validated the successful synthesis. The swelling and in vitro degradation behaviors proved that the composite hydrogel had good physical properties, while in vitro evaluations demonstrated favorable biocompatibility and osteoinductive properties. Additionally, antibacterial assessments revealed its effectiveness against common pathogens, Staphylococcus aureus and Escherichia coli. Overall, our results indicate that the CMCS/SA/β-CD-CHX/Sr-nHA composite hydrogel scaffolds exhibit significant potential for effectively treating infection-prone jaw defects.

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Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Carboxymethyl Chitosan/Sodium Alginate Composite Hydrogel Scaffolds Carrying Chlorhexidine and Strontium-Doped Hydroxyapatite

Liu,

Li,

et al. 2024

ACS Omega

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“…Therefore, studies on bone tissue engineering have proposed a new strategy for the treatment of bone defects during osteoporosis i.e., implanting strontium (Sr)-containing biomaterials (SrBMs) to continuously release Sr 2+ locally. A series of SrCMs have been extensively investigated [ 25 , [28] , [29] , [30] ]. These materials are of great significance in the treatment of osteoporosis-associated critical bone defects and compression fractures.…”

Section: Introductionmentioning

confidence: 99%

Advanced applications of strontium-containing biomaterials in bone tissue engineering

Sheng¹,

Li²,

Wang³

et al. 2023

Materials Today Bio

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“…Further, enhanced host bone healing without undesirable bacterial infections and inflammatory responses was observed in Zn 2+ and Mg 2+ co-doped nHA structures 12 . Recently, a new bone cement of co-substituted Sr 2+ and Mg 2+ (with 5 mol% of Sr and 5 mol% of Mg) nano-hydroxyapatite (n-HAs) with calcium phosphate dibasic and chitosan/gelatin polymers showed exceptional osteoblast activity for bone regeneration 13 . Such co-substitutions of ions thus offer conducive environments by combining several desirable characteristics than individual ion-substitutions of HA.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic ion substituted and Co-substituted hydroxyapatite nanoparticle synthesis using Serratia Marcescens

Paramasivan

Kumar

Kanniyappan

et al. 2023

Sci Rep

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Biomimicry is becoming deep-rooted as part of bioceramics owing to its numerous functional advantages. Naturally occurring hydroxyapatite (HA) apart from primary nano structures are also characterised by various ionic substitutions. The ease of accommodating such key elements into the HA lattice is known to enhance bone healing properties of bioceramics. In this work, hydroxyapatite synthesized via biomimetic approach was substituted with individual as well as multiple cations for potential applications in bone repair. Ion substitutions of Sr, Mg and Zn was carried out on HA for the first time by using Serratia grown in a defined biomineralization medium. The individual ions of varying concentration substituted in Serratia HA (SHA) (Sr SHA, Mg SHA and Zn SHA) were analysed for crystallinity, functional groups, morphology and crystal size. All three showed decreased crystallinity, phase purity, large agglomerated aggregates and needle-shaped morphologies. Fourier transform infrared spectroscopy (FTIR) spectra indicated increased carbonate content of 5.8% resembling that of natural bone. Additionally, the reduced O–H intensities clearly portrayed disruption of HA lattice and subsequent ion-substitution. The novelty of this study lies primarily in investigating the co-substitution of a combination of 1% Sr, Zn and Mg in SHA and establishing the associated change in bone parameters. Scanning electron microscope (SEM) and transmission electron microscope (TEM) images clearly illustrated uniform nano-sized agglomerates of average dimensions of 20–50 nm length and 8–15 nm width for Sr SHA; 10–40 nm length and 8–10 nm width for both Zn SHA and Mg SHA and 40–70 nm length and 4–10 nm width in the case of 1% Sr, Zn, Mg SHA. In both individual as well as co-substitutions, significant peak shifts were not observed possibly due to the lower concentrations. However, cell volumes increased in both cases due to presence of Sr2+ validating its dominant integration into the SHA lattice. Rich trace ion deposition was presented by energy dispersive X-ray spectroscopy (EDS) and quantified using inductively coupled plasma optical emission spectrometer (ICP-OES). In vitro cytotoxicity studies in three cell lines viz. NIH/3T3 fibroblast cells, MG-63 osteosarcoma cells and RAW 264.7 macrophages showed more than 90% cell viability proving the biocompatible nature of 1% Sr, Zn and Mg in SHA. Microbial biomineralization by Serratia produced nanocrystals of HA that mimicked “bone-like apatite” as evidenced by pure phase, carbonated groups, reduced crystallinity, nano agglomerates, variations in cell parameters, rich ion deposition and non-toxic nature. Therefore ion-substituted and co-substituted biomineralized nano SHA appears to be a suitable candidate for applications in biomedicine addressing bone injuries and aiding regeneration as a result of its characteristics close to that of the human bone.

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Magnesium (Mg2 +), Strontium (Sr2 +), and Zinc (Zn2 +) Co-substituted Bone Cements Based on Nano-hydroxyapatite/Monetite for Bone Regeneration

Cited by 12 publications

References 94 publications

Preparation and Characterization of Carboxymethyl Chitosan/Sodium Alginate Composite Hydrogel Scaffolds Carrying Chlorhexidine and Strontium-Doped Hydroxyapatite

Preparation and Characterization of Carboxymethyl Chitosan/Sodium Alginate Composite Hydrogel Scaffolds Carrying Chlorhexidine and Strontium-Doped Hydroxyapatite

Advanced applications of strontium-containing biomaterials in bone tissue engineering

Biomimetic ion substituted and Co-substituted hydroxyapatite nanoparticle synthesis using Serratia Marcescens

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