Magnesium Sulfate in Severe Perinatal Asphyxia: A Randomized, Placebo-Controlled Trial

Bhat, Mushtaq A.; Charoo, Bashir Ahmad; Bhat, Javeed I.; Ahmad, Sheikh Mushtaq; Ali, Syed Wajid; Mufti, Masood-Ul-Hassan

doi:10.1542/peds.2007-3642

Cited by 89 publications

(90 citation statements)

References 24 publications

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“…Magnesium is a naturally occurring NMDA receptor antagonist which is recommended for clinical use to combat glutamate toxicity and brain damage [4][5][6] . Literature regarding postnatal magnesium therapy after birth asphyxia revealed beneficial effects in some and no beneficial effects in others [7][8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Role of magnesium sulphate in management and prevention of short term complications of birth asphyxia

Sreenivasa

Joseph³

2017

Sri Lanka J Child Health

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Section: Introductionmentioning

confidence: 99%

Role of magnesium sulphate in management and prevention of short term complications of birth asphyxia

Sreenivasa

Joseph³

2017

Sri Lanka J Child Health

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“…4 Bhat et al found that postnatal magnesium sulfate treatment improves neurologic outcomes at discharge for term neonates with severe perinatal asphyxia. 5 Gathwala et al found that postnatal magnesium sulfate treatment with its neuroprotective action prevents brain injury from bilirubin toxicity. 6 Mohsen et al concluded that phototherapy decrease serum Mg level as it decrease serum bilirubin and there is a positive relation between serum bilirubin and serum Mg levels.…”

Section: Discussionmentioning

confidence: 99%

“…It is suggested that there is a positive correlation between plasma ionised Mg levels and severity of hyperbilirubinaemia in newborn. 4,5,6,7,8 Bilirubin exhibits an affinity for the phospholipids of the plasma membrane, such as the N-Methyl-D-Aspartate (NMDA) receptors. Therefore, it seems that the activation of NMDA receptors may induce neuronal injury, which could be blocked by the antagonists of the NMDA receptors.…”

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confidence: 99%

Effect of Double Surface Phototherapy on Serum Magnesium Levels in Term and Late Preterm Neonates

Ravichander¹,

Kundu²

2018

jebmh

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BACKGROUNDHyperbilirubinaemia is one of the most common sign encountered in newborns. Untreated, severe unconjugated hyperbilirubinaemia is potentially neurotoxic. Phototherapy is the first line of treatment in neonatal hyperbilirubinaemia. Phototherapy has potential complications like dehydration, electrolyte and haematological changes, etc. Limited studies on magnesium changes after giving phototherapy. Hence, present study to find out magnesium level changes after double surface phototherapy.

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“…Systematic reviews have found a significant reduction in the rate of cerebral palsy in children born to magnesiumtreated women at risk of preterm delivery, 81,82 and a clinical trial found that postnatal magnesium sulfate treatment improves neurologic outcome for term neonates with severe perinatal asphyxia. 83 …”

Section: What Might Be Done?mentioning

confidence: 99%

Developmental Disability in the Young and Postoperative Cognitive Dysfunction in the Elderly After Anesthesia and Surgery: Do Data Justify Changing Clinical Practice?

Cottrell

Hartung

2012

Mount Sinai J Medicine

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The assumption that anesthesia has no serious, long‐term, adverse central nervous system consequences may be true for most patients between 6 months and 60 years of age. However, for patients younger than 6 months or older than 60 years, that status quo assumption is under challenge from a growing body of evidence. Fetuses and newborns appear to be at risk because systems that would enable them to fully recover from the effects of more than 2 hours of anesthesia are still in development. In distinction, the elderly appear to be at risk because systems that once enabled them to fully recover have ever‐diminishing capacity. Even for those between the age of 6 months and 60 years, full recovery may require replacing apoptosed neurons and pruning overabundant dendritic spines … perhaps leaving patients not quite the same person that they were before they were anesthetized. Mt Sinai J Med 79:75–94, 2012. © 2012 Mount Sinai School of Medicine

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Magnesium Sulfate in Severe Perinatal Asphyxia: A Randomized, Placebo-Controlled Trial

Abstract: Postnatal magnesium sulfate treatment improves neurologic outcomes at discharge for term neonates with severe perinatal asphyxia.

Cited by 89 publications

References 24 publications

Role of magnesium sulphate in management and prevention of short term complications of birth asphyxia

Role of magnesium sulphate in management and prevention of short term complications of birth asphyxia

Effect of Double Surface Phototherapy on Serum Magnesium Levels in Term and Late Preterm Neonates

Developmental Disability in the Young and Postoperative Cognitive Dysfunction in the Elderly After Anesthesia and Surgery: Do Data Justify Changing Clinical Practice?

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