Magnesium sulphate improves pulmonary function after video-assisted thoracoscopic surgery

Abstract

cris.nih.go.kr identifier: KCT0001410.

Possibility of magnesium supplementation for supportive treatment in patients with COVID-19

“…In a clinical trial with a total of 2907 randomized patients, atomized magnesium sulfate, combined with inhaled β2-agonist and ipratropium bromide, have modest additional benefits in terms of pulmonary function and hospitalization ( Knightly et al, 2017 ). Additionally, intraoperative administration of magnesium sulfate (50 mg/kg intravenously for 10 min, followed by continuous infusion of 15 mg/kg/h during the operation) improves lung function in patients receiving video-assisted thoracoscopic surgery, and reduces the doses of rocuronium and postoperative analgesics ( Sohn et al, 2017 ).…”

Reducing the dose of neuromuscular blocking agents with adjuncts: a systematic review and meta-analysis

“…22,47,49 There was a reduction in extubation time after dexmedetomidine 22 Residual neuromuscular block. Two studies 26,47 reported data on train-of-four ratio on arrival to PACU. For magnesium, the TOF ratio after was greater than 0.9 for both intervention and normal saline, 26 whereas lidocaine was associated with a higher TOF ratio.…”

“…Two studies 26,47 reported data on train-of-four ratio on arrival to PACU. For magnesium, the TOF ratio after was greater than 0.9 for both intervention and normal saline, 26 whereas lidocaine was associated with a higher TOF ratio. 47 No other studies reported either clinical or electromyographic data regarding residual neuromuscular block.…”

Association between perioperative cholesterol level and analgesia after video-assisted thoracoscopic surgery

“…A total of 1,952 patients over the age of 19 years were diagnosed with NSCLC and underwent VATS lobectomy between January 1, 2011, and July 31, 2017. Among these patients, the following cases were excluded from the analysis: 1) 86 cases with missing data on pain outcomes or on TSC; 2) 92 cases with intraoperative conversion of the procedure to open thoracotomy, bilobectomy, or pneumonectomy; 3) 38 cases of surgery involving organs outside the thoracic cavity; 4) 12 cases in which epidural analgesia was performed; and 5) 4 patients who participated in clinical trials using intraoperative magnesium sulfate infusion [12]. Thus, a total of 1,720 patients were included in the analysis.…”

“…In addition, we included patients who underwent sublobar resection on other ipsilateral pulmonary lobes in the ‘lobectomy’ category but excluded those who underwent sublobar resection on the lung contralateral to the one on which lobectomy had been performed. The exclusion criteria included the following: requirement for additional operations within two days after lobectomy; intraoperative conversion of the procedure to open thoracotomy; conversion of the procedure to bilobectomy or pneumonectomy; missing or inaccurate data on pain outcomes or TSC; requirement for thoracic epidural analgesia; patients who participated in randomized trials that required the intraoperative infusion of magnesium sulfate [12]; and surgery involving organs outside the thoracic cavity.…”