Magnesium Supplementation Alleviates Premenstrual Symptoms of Fluid Retention

Walker, Ann F.; Souza, Miriam Coelho; Vickers, M.F.; Abeyasekera, S.; Collins, Marilyn L.; Trinca, Luzia A.

doi:10.1089/jwh.1998.7.1157

Cited by 105 publications

(49 citation statements)

References 13 publications

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“…160 A recent study reported that 80 mg daily of pyridoxine was superior to placebo in relieving anxiety and mood premenstrual symptoms but not physical symptoms. 161 Two small RCTs have suggested the efficacy of magnesium, 162,163 but other studies have failed to document magnesium deficiency in women with PMDD or improvement of premenstrual symptoms with supplemental magnesium when compared with placebo. 164 An RCT reported superior efficacy for trytophan, compared with placebo, in women with PMDD, 165 and an early study that suggested efficacy for vitamin E deserves replication.…”

Section: Dietary Supplementationmentioning

confidence: 99%

Premenstrual Dysphoric Disorder: Burden of Illness and Treatment Update

Pearlstein¹,

Steiner²

2012

FOC

103

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291Five percent of menstruating women have severe premenstrual symptoms and impairment of functioning defined as premenstrual dysphoric disorder (PMDD). Clinically significant premenstrual symptoms occur in at least an additional 20% of menstruating women. The diagnosis of PMDD should be confirmed by prospective symptom charting over 2 menstrual cycles to confirm the timing of the symptoms and to rule out other diagnoses. The burden of illness of PMDD includes disruption of parenting and partner relationships and decreased productivity in work roles. In addition, women with PMDD have increased use of health care services such as clinician visits and increased use of prescription medications and over-the-counter preparations. The etiology of PMDD is multifactorial. In particular, dysregulation of the serotonin and allopregnanolone systems is implicated. Several effective treatment options exist, including serotonergic antidepressant medications and an oral contraceptive that contains ethinyl estradiol and drosperinone. In addition, other hormones that suppress ovulation, anxiolytics, cognitive therapy, chasteberry and calcium may be helpful.Cinq pour cent des femmes menstruées ont des symptômes prémenstruels sévères et une incapacité du fonctionnement appelée trouble dysphorique prémenstruel (TDPM). Au moins 20 % de femmes menstruées de plus ont des symptômes prémenstruels cliniquement significatifs. Il faut confirmer le diagnostic de TDPM en suivant les symptômes de façon prospective au cours de deux cycles menstruels afin de confirmer le moment de l'apparition des symptômes et d'exclure d'autres diagnostics. Le fardeau morbide imposé par le TDPM comprend la perturbation des relations avec les enfants et le partenaire et une baisse de productivité au travail. Les femmes atteintes de TDPM ont en outre recours davantage aux services de santé comme les visites aux cliniciens et prennent davantage de médicaments d'ordonnance et en vente libre. L'étiologie du TDPM est multifactorielle. La dysrégulation des systèmes de la sérotonine et de l'allopregnanolone en particulier est mise en cause. Il existe plus d'un traitement efficace possible, y compris des antidépresseurs sérotonin-ergiques et un contraceptif oral qui contient de l'éthinyloestradiol et de la drosperinone. D'autres hormones qui bloquent l'ovulation, des anxiolytiques, la thérapie cognitive, le gattilier (Vitex agnus castus) et le calcium peuvent en outre aider. Review Paper Examen critique DiagnosisAbout 80% of women report at least mild premenstrual symptoms, 20%-50% report moderate-to-severe premenstrual symptoms, and about 5% report severe symptoms for several days with impairment of functioning.

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Section: Dietary Supplementationmentioning

confidence: 99%

Premenstrual Dysphoric Disorder: Burden of Illness and Treatment Update

Pearlstein¹,

Steiner²

2012

FOC

103

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“…Deficiencies in plasma (Posaci et al 1994), red blood cell (RBC; Abraham et al 1981;Rosenstein et al 1994;Sherwood et al 1986;Stewart et al 1986), and mononuclear blood cell (MBC; Rosenstein et al 1994) Mg concentrations have been observed in women with PMS relative to women without PMS. Additionally, two placebo-controlled, double-blind, prospective clinical trials of oral Mg supplementation in women with PMS found that Mg was superior to placebo in the alleviation of mood (Facchinetti et al 1991) and fluid retention symptoms (Walker et al 1998). One interpretation of these findings is that women with PMS are Mg deficient and that Mg replacement may be a treatment for some of the core symptoms of this disorder.…”

mentioning

confidence: 99%

Magnesium (Mg) Retention and Mood Effects After Intravenous Mg Infusion in Premenstrual Dysphoric Disorder

Khine¹,

Rosenstein²,

Elin

et al. 2006

Biological Psychiatry

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“…Nutritional supplements which have proven efficacy that have been evaluated in women with PMS include vitamins, calcium, magnesium, multivitamin/mineral supplements, evening primrose oil and chaste-tree berry (Wyatt and colleagues 1999;Kleijnen et al 1990;London et al 1987;Dickerson 2003;Thys-Jacobs et al 1998;Facchinetti et al 1991;Walker et al 1998). …”

Section: Non-pharmacologic Treatments Of Pmsmentioning

confidence: 99%

“…However, the possibility that renal calculi might develop has been a concern with calcium supplementation (Frye & Silverman 2000). Magnesium supplementation was also found to be effective in alleviating some of the PMS symptoms in Italy (Facchinetti et al 1991) and in the United Kingdom (Walker et al 1998 should not be routinely recommended for women with PMS since high dose of this vitamin for prolonged periods of time can cause neurological symptoms.…”

Section: Non-pharmacologic Treatments Of Pmsmentioning

confidence: 99%

A Controlled Trial of Chinese Herbal Medicine for Premenstrual Syndrome

Chou¹,

Morse²,

Xu³

et al. 2009

Deutsche Zeitschrift für Akupunktur

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Premenstrual syndrome is a common disorder troubling many women during their reproductive years. The Chinese have been using herbal medicines to treat menstrual cycle related symptoms for centuries. Traditional Chinese medicine provides the aetiology and pathogenesis of the symptoms of this disorder by applying Pattern Identification to diagnose the signs and symptoms of individual patients and to design individualised treatments which seek to address the entire pattern/s of disharmony. It follows that PMS, which has many symptoms and an idiosyncratic nature, is precisely an area for which Chinese medicine is most suitable. The aim of this study is to scientifically evaluate the effectiveness of Chinese herbal medicine on Australian women for the treatment of PMS within the theoretical frame-work of TCM. A double-blind randomized placebo-controlled crossover clinical trial was conducted by a qualified Chinese herbal practitioner and pharmacist. Following two months confirmatory assessment, sixty-one subjects were assigned randomly into two groups within different TCM patterns of Liver Qi Stagnation, Liver and Kidney Yin Deficiency, Liver and Spleen Disharmony and Heart and Spleen Deficiency. Herbal medicine (n=31) and placebo (n=30) were provided sequentially for a period of three months. There were significant differences (p < .01) in scores after three months of treatment between Chinese herbal medicine and placebo in premenstrual physical and psychological symptoms, depression, anxiety and anger, but with no difference in perceived stress (p > .05). There were highly significant reductions (p< .001) in all assessments in both groups except that a significant result (p < .05) was recorded on perceived

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Magnesium Supplementation Alleviates Premenstrual Symptoms of Fluid Retention

Abstract: We investigated the effect of a daily supplement of 200 mg of magnesium (as MgO)

Cited by 105 publications

References 13 publications

Premenstrual Dysphoric Disorder: Burden of Illness and Treatment Update

Premenstrual Dysphoric Disorder: Burden of Illness and Treatment Update

Magnesium (Mg) Retention and Mood Effects After Intravenous Mg Infusion in Premenstrual Dysphoric Disorder

A Controlled Trial of Chinese Herbal Medicine for Premenstrual Syndrome

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