Only limited data are reported on the response to granulocyte-colony stimulating factor (G-CSF) of large granular lymphocytosis-associated neutropenia. We report features of such a case who developed a suppurating leg ulcer following a dog bite. G-CSF was used to increase the neutrophil count, allowing the ulcer to be successfully skin grafted.
The reciprocal translocation of genetic material t(8;2 l), and the third had a variant t(8;2 1) translocation. between chromosomes 8 and 21, t(8:21), is usuallyWe discuss the significance of t(8;21) in the aetiology of restricted to cases of acute myeloid leukaemia (AML). myelodysplastic syndrome (MDS) and implications for the Cases of AML with t( 8;21) exhibit characteristic dysplastic management of such patients. features in myeloid and erythroid lineages with reduction in megakaryocytes. We report details of three patients presenting with myelodysplastic features: two had a typical
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