Magnesium valproate ameliorates type 1 diabetes and cardiomyopathy in diabetic rats through estrogen receptors

Rabadiya, Samir; Bhadada, Shradhha; Dudhrejiya, Ashvin; Vaishnav, Devendra; Patel, Bhoomika M.

doi:10.1016/j.biopha.2017.10.137

Cited by 18 publications

(7 citation statements)

References 60 publications

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“…Similar results were obtained by other researchers who, in addition to the reduced cardiomyocyte diameter, showed that there was a decrease in the thickness of the left ventricular wall in diabetic rats [72]. In contrast to our results, Rabadiya et al obtained increased left ventricular wall thickness and left ventricular cardiomyocyte diameter [73], while other authors demonstrated that there was no difference in left ventricular cardiomyocyte diameter [15].…”

Section: Discussionsupporting

confidence: 89%

The Effects of Folic Acid Administration on Cardiac Oxidative Stress and Cardiovascular Biomarkers in Diabetic Rats

Mutavdzin

Gopčević

Stanković³

et al. 2019

Oxidative Medicine and Cellular Longevity

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The aim of this study was to examine the effects of folic acid administration on the antioxidant enzyme (superoxide dismutase (SOD) and catalase (CAT)) activities, lactate and malate dehydrogenase (LDH and MDH) activities, and certain LDH and MDH isoform distribution in the cardiac tissue of diabetic Wistar male rats. Diabetes mellitus (DM) was induced by streptozotocin (STZ). There were five groups: C1—control (physiological saline 1 ml/kg, i.p. one day), C2—control with daily physiological saline treatment (1 ml/kg, i.p. 28 days), DM—diabetes mellitus (STZ 100 mg/kg in physiological saline, i.p. one day), FA—folic acid (5 mg/kg in physiological saline, i.p. 28 days), and DM+FA—diabetes mellitus and folic acid group (STZ 100 mg/kg in physiological saline, i.p. one day, and folic acid 5 mg/kg in physiological saline, i.p. 28 days). After four weeks, animal hearts were isolated for measurement of enzyme activities, as well as for histomorphometry analyses. An elevated glucose level and a decreased insulin level were obtained in the DM group. SOD, CAT, and MDH activities were elevated in the DM group, while there was no difference in LDH activity among the groups. In all tested groups, four LDH and three MDH isoforms were detected in the heart tissue, but with differences in their relative activities among the groups. Left ventricular cardiomyocyte transversal diameters were significantly smaller in both diabetic groups. Folic acid treatment of diabetic rats induced a reduced glucose level and reduced CAT, SOD, and MDH activities and alleviated the decrease in cardiomyocyte diameters. In conclusion, increased activities of antioxidant enzymes and MDH may be the consequence of oxidative stress caused by DM. Administration of the folic acid has a protective effect since it leads to reduction in glycemia and activities of the certain examined enzymes in the rats with experimentally induced DM.

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Section: Discussionsupporting

confidence: 89%

The Effects of Folic Acid Administration on Cardiac Oxidative Stress and Cardiovascular Biomarkers in Diabetic Rats

Mutavdzin

Gopčević

Stanković³

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Experiments in diabetic rats treated with VPA showed a dose-dependent reduction in blood glucose, which peaked around the 21 st day of administration (a reduction of 52.79%), whilst in normal glycemic rats the peak was reached over the same period at a percentage of 15.63% [11]. These results and further findings on animal models [12] suggest that VPA has antidiabetic properties.…”

Section: Key Pointssupporting

confidence: 51%

Iatrogenic Hypoglycemia Induced by Valproic Acid in an Adult Patient

Rota

Varese²,

Arena

et al. 2021

CMI

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Literature on antiepileptic induced iatrogenic hypoglycemia is scanty. Due to its broad spectrum of activity and mechanisms of action, valproic acid (VPA), a fatty acid, is the most widely prescribed epilepsy treatment worldwide.Herein, we describe an adult epileptic patient, where persistent, otherwise unexplained hypoglycemia, was most likely induced by VPA, as suggested by the VPA time course and glucose blood levels. Indeed, no further hypoglycemic episodes occurred after VPA discontinuation and the diagnostic work-up ruled out other possible causes of hypoglycemia.This case supports the hypothesis that VPA may induce hypoglycemia, due to still not well-defined metabolic mechanisms of action. Moreover, it emphasizes the fact that an iatrogenic pathogenesis should be considered if an apparently unexplained hypoglycemia occurs in a patient on chronic therapy with antiepileptics, even at a therapeutical dosage.

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“…Heart tissue was isolated in both models and collagen content (Sharma et al 2019) and Na + K + ATPase (Patel, Raghunathan, et al 2014;Rabadiya et al 2018) activity in heart tissue was estimated as reported earlier.…”

Section: Tissue Collectionmentioning

confidence: 99%

Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia

Bora

Patel

Johar

et al. 2022

Can. J. Physiol. Pharmacol.

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Cancer cachexia is mainly characterized by wasting of skeletal muscles, fat and body weight loss, along with severe complications of major organs like liver, heart, brain and bone. There can be diminishing performance of these major organs as cancer cachexia progresses, one such drastic effect on the cardiac system. In present study, differential effect of histone deacetylase inhibitors (HDACi) on cardiac complications associated with cancer cachexia is studied. Two models were used to induce cancer cachexia: B16F1 induced metastatic cancer cachexia and LLC induced cancer cachexia. Potential of Class I HDAC inhibitor Entinostat, Class II HDAC inhibitor MC1568 and non-specific HDAC inhibitor sodium butyrate on cardiac complications were evaluated using the cardiac hypertrophy markers, hemodynamic markers and cardiac markers along with histopathological evaluation of heart sections by periodic acid schiff staining, masson trichrome staining, picro sirius red staining and haematoxylin and eosin staining. Immunohistochemistry evaluation by vimentin and caspase 3 protein expression was evaluated. Entinostat showed promising results by attenuating the cardiac complications, MC1568 treatment further exacerbated the cardiac complications while non-conclusive effect were recorded after treatment with sodium butyrate. Further, this study will be helpful in evaluating other HDAC inhibitors for potential in cardiac complications associated with cancer cachexia.

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Magnesium valproate ameliorates type 1 diabetes and cardiomyopathy in diabetic rats through estrogen receptors

Cited by 18 publications

References 60 publications

The Effects of Folic Acid Administration on Cardiac Oxidative Stress and Cardiovascular Biomarkers in Diabetic Rats

The Effects of Folic Acid Administration on Cardiac Oxidative Stress and Cardiovascular Biomarkers in Diabetic Rats

Iatrogenic Hypoglycemia Induced by Valproic Acid in an Adult Patient

Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia

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