Magnetic chitosan microspheres: preparation and characterization

Denkbaş, Emir Baki; Kılıçay, Ebru; Birlikseven, Cengiz; Öztürk, Emel

doi:10.1016/s1381-5148(01)00115-8

Cited by 237 publications

(111 citation statements)

References 22 publications

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“…Therefore, it is necessary to use polymers in the coating process to prevent the nuclear growth of iron oxide, preclude nanoparticles aggregation, and reduce toxic effect. [23][24][25] CS, a natural polymer and deacetylated derivative of chitin, is most commonly used as a coating material for nanoparticles in anticancer drug delivery systems because of its unique biological features including biocompatibility, 26 anti-carcinogenicity, biodegradability, nontoxicity, hydrophilicity, 23,[27][28][29] and great antimicrobial property. 30 The CS polymer reacts with iron oxide nanoparticles through glycosidic bonds and improves the stability and chemical reactivity of nanoparticles.…”

mentioning

confidence: 99%

Sustained release of anticancer agent phytic acid from its chitosan-coated magnetic nanoparticles for drug-delivery system

Barahuie

Dorniani

Saifullah

et al. 2017

IJN

105

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mentioning

confidence: 99%

Sustained release of anticancer agent phytic acid from its chitosan-coated magnetic nanoparticles for drug-delivery system

Barahuie

Dorniani

Saifullah

et al. 2017

IJN

105

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“…The most effective parameters determining the magnetic quality of the microspheres were the stirring rate and the magnetic materials contents of the microspheres, and these parameters were varied in the range of 500-1000 rpm and 1 : 3-1 : 1 mL Fe 3 O 4 /g chitosan, respectively. 9 DSC methods DSC was performed using a PerkinElmer DSC instrument with intracooler. The samples were purged with the atmosphere of nitrogen.…”

Section: Magnetic Propertiesmentioning

confidence: 99%

Synthesis and characterization of composite magnetic microspheres of artemisia seed gum and chitosan

Zhang

Wang

et al. 2006

J of Applied Polymer Sci

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In this study, composite magnetic microspheres of artemisia seed gum and chitosan were prepared in a well-shaped spherical form with a size range of 230-460 mm by the suspension crosslinking technique for use in the application of magnetic carrier technology. The magnetic material used in the preparation of the composite microspheres was prepared by precipitation from FeCl 3 and FeSO 4 solution in basic medium. The morphological, magnetic properties, and the functional groups of the microspheres were characterized by different techniques (i.e., SEM, magnetometry, and FTIR). The results demonstrated that the stirring rate of the suspension and the Fe 3 O 4 /chitosan ratio are the most effective parameters for the average of the size distributions and the magnetic quality of the microspheres, while the amount of artemisia seed gum and Tween-80 have no significant effect on these properties. The best magnetic quality of the composite magnetic microspheres is around 4.08 emu/g microspheres at 10 KG magnetic field intensity. The thermal stability of the composite magnetic microspheres was measured by using DSC methods.

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“…Owing to the presence of free amino groups in chitosan, the solubility and reactivity of this polymer are greater than those of chitin [2]. In addition, chitosan has many significant biological and chemical properties: it is biodegradable, biocompatible, bioactive, and polycationic [3]. Thus, it has been widely used in many industrial and biomedical aspects, including in enzyme immobilization, and as carrier for controlled drug delivery [4]- [7].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Activity of Drug Delivery System Based on Chitosan Nanocapsules

Gouda¹,

El‐Ayaan²,

Youssef³

2014

ANP

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Chitosan nanocapsules containing naproxen as an active ingredient were synthesized by ionic gelation method in presence of polyanion tripolyphosphate as a crosslinker. The morphology and diameter of the prepared chitosan nanoparticles was characterized using scanning electron microscopy and transition electron microscopy. Different factors affecting on the size diameter of chitosan nanoparticles such as stirring time and temperature, pH values as well as chitosan concentration were studied. Different factors affecting on the immobilization of naproxen into chitosan nanoparticles such as time, temperature and pH values were optimized. Synthesized naproxen/chitosan nanocapsules were assessed against both Gram positive bacterial strain such as Bacillus subtilis and Staphylococcus aureus and Gram negative bacterial strain such as Pseudomonas aeruginosa and Escherichia coli. Also, the antifungal activity of the naproxen/chitosan nanocapsules against Saccharomyces cerevisiae was demonstrated. Super oxide dismutase like activity of naproxen/chitosan nanocapsules will be determined.

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Magnetic chitosan microspheres: preparation and characterization

Cited by 237 publications

References 22 publications

Sustained release of anticancer agent phytic acid from its chitosan-coated magnetic nanoparticles for drug-delivery system

Sustained release of anticancer agent phytic acid from its chitosan-coated magnetic nanoparticles for drug-delivery system

Synthesis and characterization of composite magnetic microspheres of artemisia seed gum and chitosan

Synthesis and Biological Activity of Drug Delivery System Based on Chitosan Nanocapsules

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