Magnetic CLEAR Supports for Solid-Phase Synthesis of Peptides and Small Organic Molecules

Sasikumar, Pottayil G.; Kempe, Maria

doi:10.1007/s10989-006-9056-x

Cited by 8 publications

(1 citation statement)

References 59 publications

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“…In the case of the unstable MBs prepared by the co‐precipitation method, these can be first dispersed in water, and then modified by adding organic small molecules. Another approach to couple MNPs with small organic molecule consists of adding such molecules in the process of preparing MBs; for the lipophilic MBs, they can be modified by further special interactions between ornaments or ligands exchange reactions are utilized to achieve water‐solubility and biocompatibility of NPs . In the following paragraphs, we discuss a series of approaches for modifying MNPs to include small organic molecules.…”

Section: Synthesis and Surface Modification Of Magnetic Materialsmentioning

confidence: 99%

Applications of magnetic materials separation in biological nanomedicine

Chen

Iqbal

et al. 2019

Electrophoresis

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As a result of their advantages for superparamagnetic properties, good biocompatibility, and high binding capacity, functionalized magnetic materials became widely popular over the past couple of decades, being applied on large scale in various processes of sample preparation for biomedicine. In this work, we perform an in‐depth review on the current progress in the field of magnetic bead separation, discussing in detail the physical basis of this process, various synthesis methods and surface modification strategies. We place special focus of attention as well on the latest applications of magnetic polymer microspheres in cell separation, protein purification, immobilized enzyme, nucleic acid separation, and extraction of bioactive compounds with low molecular weight. Existing problems are highlighted and possible trends of magnetic separation techniques for biomedicine in the future are proposed.

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Section: Synthesis and Surface Modification Of Magnetic Materialsmentioning

confidence: 99%

Applications of magnetic materials separation in biological nanomedicine

Chen

Iqbal

et al. 2019

Electrophoresis

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Peptide Synthesis

Sewald

Jakubke

2009

Peptides: Chemistry and Biology

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Magnetic Silyl Scaffold Enables Efficient Recycling of Protecting Groups

Schaetz

Zeltner

Michl

et al. 2011

Chemistry A European J

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A novel organic/inorganic hybrid material comprising carboncoated cobalt nanoparticles and a poly(benzylchloride)styrene shell is the first magnetic support that complies with important requirements for immobilized reagents and scavengers, that is, stability under harsh conditions (e.g., acids), sufficient loading (up to 2 mmol g(-1)), and satisfying magnetization. The durability of the scaffold was demonstrated by immobilization of a trialkylsilane reagent, which served as a "magnetic" protecting group for a number of primary and secondary alcohols. Importantly, the scaffold could be efficiently separated, recycled, and reused after alcohol cleavage (HF·pyridine) via regeneration of the silyl chloride moiety with BCl(3).

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Magnetic CLEAR Supports for Solid-Phase Synthesis of Peptides and Small Organic Molecules

Cited by 8 publications

References 59 publications

Applications of magnetic materials separation in biological nanomedicine

Applications of magnetic materials separation in biological nanomedicine

Peptide Synthesis

Magnetic Silyl Scaffold Enables Efficient Recycling of Protecting Groups

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