Magnetic drug-targeting carrier encapsulated with thermosensitive smart polymer: Core–shell nanoparticle carrier and drug release response

Size control of magnetite nanoparticles by organic solvent-free chemical coprecipitation at room temperature

“…These results imply that the synthesis conditions influence greatly not only the Fe 3 O 4 formation reaction but also the formation of Fe(OH) 2 and -FeOOH precipitates. Accordingly, in order to control the size of Fe 3 O 4 nanoparticles, the formation process of Fe(OH) 2 and -FeOOH precipitates should be also controlled. Kandori et al [7,8] reported that the formation and crystal growth of -FeOOH colloids was influenced by the anionic species existing together with ferric ions in the solution.…”

“…Recent reports reveal that the size of Fe 3 O 4 nanoparticles thus formed greatly depends on the concentration of ferrous and ferric ions [5] and the reaction temperature [6]. These results imply that the synthesis conditions influence greatly not only the Fe 3 O 4 formation reaction but also the formation of Fe(OH) 2 and -FeOOH precipitates. Accordingly, in order to control the size of Fe 3 O 4 nanoparticles, the formation process of Fe(OH) 2 and -FeOOH precipitates should be also controlled.…”

“…In biomedical applications, particularly, precise control of the particle size is required. For example, for drug delivery system Lin et al [1] and Zhang and Misra [2] synthesised the Fe 3 O 4 nanoparticles of about 20 nm and 5 nm using a liquid phase coprecipitation method and a thermal decomposition method, respectively. Wang et al [3] applied the Fe 3 O 4 nanoparticles of about 20 nm synthesised by an electrochemical deposition method for cancer therapy.…”

“…However, coprecipitation techniques in water systems without using any organic solvents are promising as a useful preparation method because the synthesis process can be simplified and the environmental impact is relatively low. In widely used coprecipitation methods, hydroxides of ferrous and ferric ions, ferrous hydroxide (Fe(OH) 2 ) and goethite (-FeOOH), are coprecipitated as precursors in an alkaline solution at relatively low temperature. The molar ratio of ferrous ion to ferric ion is 0.5, corresponding to the chemical stoichiometric ratio of Fe 3 O 4 formation reaction [4].…”

Hydrothermal synthesis of magnetite nanoparticlesviasequential formation of iron hydroxide precipitates

“…At present, magnetic iron oxides are also utilised for printing and electrophotography such as copying toner [2] and carrier powders [3]. Recently, bio-applications of magnetic iron oxides have been attracting attention, and especially medical applications using Fe 3 O 4 nanoparticles have been studied actively, for example, magnetic resonance imaging [4,5], drug delivery system [6,7], cancer therapy [8,9], etc. Under such circumstances, fine ferromagnetic Fe 3 O 4 nanoparticles of which the size is precisely controlled suitable for their applications are needed.…”