Magnetic enhancement of iron oxide nanoparticles encapsulated with poly(d,l-latide-co-glycolide)

Lee, Seungjun; Jeong, Jong‐Ryul; Shin, Sung‐Chul; Kim, Jin‐Chul; Chang, Young-Hwan; Lee, Kwon‐Hyung; Kim, Jong-Duk

doi:10.1016/j.colsurfa.2004.12.019

Cited by 87 publications

(44 citation statements)

References 22 publications

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“…These sub-micron particles exhibited superparamagnetic property. Lee et al [217] utilized the emulsification-diffusion method to prepare high magnetically susceptible iron oxide NPs (8-20 nm) encapsulated within PLGA (spherical shape with 90-180 nm). By increasing of the homogenization strength in the emulsification step as well as the agitation speed in the solvent diffusion stage, the average size of the encapsulated SPIONs was controlled to achieve a high magnetic susceptibility.…”

Section: Synthetic Polyestersmentioning

confidence: 99%

Recent advances in surface engineering of superparamagnetic iron oxide nanoparticles for biomedical applications

Mahmoudi

Simchi

Imani

2010

JICS

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Superparamagnetic iron oxide nanoparticles (SPIONs) are promising materials for various biomedical applications including targeted drug delivery and imaging, hyperthermia, magneto-transfections, gene therapy, stem cell tracking, molecular/cellular tracking, magnetic separation technologies (e.g. rapid DNA sequencing), and detection of liver and lymph node metastases. The most recent applications for SPIONs for early detection of inflammatory, cancer, diabetes and atherosclerosis have also increased their popularity in academia. In order to increase the efficacy of SPIONs in the desired applications, especial surface coating/characteristics are required. The aim of this article is to review the surface properties of magnetic nanoparticles upon synthesis and the surface engineering by different coatings. The biological aspects, cytotoxicity, and health risks are addressed. Special emphasis is given to organic and inorganic-based coatings due to their determinant role in biocompatibility or toxicity of the final particles.

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Section: Synthetic Polyestersmentioning

confidence: 99%

Recent advances in surface engineering of superparamagnetic iron oxide nanoparticles for biomedical applications

Mahmoudi

Simchi

Imani

2010

JICS

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“…This class of polymer microparticles has been studied extensively to encapsulate compounds for sustained release for many applications, including vaccine delivery (Lee et al, 1997a, b), cancer treatment (Birnbaum and Brannon-Peppas, 2003), hormone therapy (Lee et al, 1997a, b), protein delivery (Jain et al, 2005), gene delivery (Little et al, 2004), and diagnostic applications (Lee et al, 2005). These microparticles are typically prepared using an oil-water, double-emulsion system; spray drying methods; supercritical conditioning methods; and milling methods (Benoit et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Polymer particle-based micromolding to fabricate novel microstructures

Park

Choi

Kamath

et al. 2006

Biomed Microdevices

108

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Conventional micromolding provides rapid and low-cost methods to fabricate polymer microstructures, but has limitations when producing sophisticated designs. To provide more versatile micromolding techniques, we developed methods based on filling micromolds with polymer microparticles, as opposed to polymer melts, to produce microstructures composed of multiple materials, having complex geometries, and made using mild processing conditions. Polymer microparticles of 1 to 30 µm in size were made from PLA, PGA and PLGA using established spray drying and emulsion techniques either with or without encapsulating model drug compounds. These polymer microparticles were filled into PDMS micromolds at room temperature and melted or bonded together to form microstructures according to different protocols. Porous microstructures were fabricated by ultrasonically welding microparticles together in the mold while maintaining the voids inherent in their packing structure. Multi-layered microstructures were fabricated to have different compositions of polymers and encapsulated compounds located in different regions of the microstructures. More complex arrowhead microstructures were fabricated in a two-step process using a single mold. To assess possible applications, microstructures were designed as microneedles for minimally invasive drug delivery. Multilayer microneedles were shown to insert into cadaver tissue and, according to design, detach from their base substrate and remain embedded in the tissue for controlled release drug delivery over time. We conclude that polymer particlebased micromolding can encapsulate compounds within microstructures composed of multiple materials, having complex geometries, and made using mild processing conditions.

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“…Many approaches are proposed for the preparation of PLGA NPs. The emulsificationeevaporation method [3,11e13], spontaneous emulsificationesolvent diffusion method (SESD) [14,15], and nanoprecipitation method [6,16] are all widely used for preparing various diameters of PLGA NPs. During nanoparticles formation by emulsificationeevaporation and SESD approaches, toxic organic solvents such as CH 2 Cl 2 and CHCl 3 are usually used.…”

Section: Introductionmentioning

confidence: 99%

Stabilizer-free poly(lactide-co-glycolide) nanoparticles for multimodal biomedical probes

et al. 2008

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Magnetic enhancement of iron oxide nanoparticles encapsulated with poly(d,l-latide-co-glycolide)

Cited by 87 publications

References 22 publications

Recent advances in surface engineering of superparamagnetic iron oxide nanoparticles for biomedical applications

Recent advances in surface engineering of superparamagnetic iron oxide nanoparticles for biomedical applications

Polymer particle-based micromolding to fabricate novel microstructures

Stabilizer-free poly(lactide-co-glycolide) nanoparticles for multimodal biomedical probes

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