Magnetic field and nuclear spin influence on the DNA synthesis rate

Abstract

The rate of a chemical reaction can be sensitive to the isotope composition of the reactants, which provides also for the sensitivity of such “spin-sensitive” reactions to the external magnetic field. Here we demonstrate the effect of the external magnetic field on the enzymatic DNA synthesis together with the effect of the spin-bearing magnesium ions ($$^{25}$$ 25 Mg). The rate of DNA synthesis monotonously decreased with the external magnetic field induction increasing in presence of zero-spin magnesium ions ($$^{24}$$ 24 Mg). On the contrary, in the presence of the spin-bearing magnesium ions, the dependence of the reaction rate on the magnetic field induction was non-monotonous and possess a distinct minimum at 80–100 mT. To describe the observed effect, we suggested a chemical scheme and biophysical mechanism considering a competition between Zeeman and Fermi interactions in the external magnetic field.

A Review of the Current State of Magnetic Force Microscopy to Unravel the Magnetic Properties of Nanomaterials Applied in Biological Systems and Future Directions for Quantum Technologies

“…Furthermore, phosphorylation is not only crucial to regulate DNA replication but, also, to control the energy supply in the cellular and tissue metabolisms [153], the proper functioning of the immunological system [154], and the muscular contraction [155], among others. Recently, it was discovered that the impact of B on the ATP synthesis and subsequent phosphorylation process took place during DNA replication [156]. The rate of ATP synthesis by creatine kinase increased nearly 3.5-fold at B of 55 mT when the 24 Mg nonmagnetic ions were exchanged by the respective paramagnetic 25 Mg [157].…”

Hypomagnetic Conditions and Their Biological Action (Review)

“…A magnetic nanoparticle can change the rate of spin-dependent chemical reactions under the influence of external magnetic fields [224]. The limit of sensitivity to magnetic fields with induction of the order of GMP for magnetic nanoparticles is about 2 degrees [225], which can provide good accuracy for navigation of migrating birds and animals [225][226][227][228].…”

Triggering gel‐sol transition by weak magnetic field

“…On the other hand, a static magnetic field can inhibit apoptosis, increasing the risk of cancer 3,4 . Besides that, a low‐frequency electromagnetic field can promote DNA fragmentation in human cells, 5 while a relatively weak static magnetic field of 0.2 T significantly affects the DNA synthesis rate 6 . These observations determine the fundamental importance of the interaction of the magnetic field with soft matter.…”