Magnetic field desensitizes 5-HT1B receptor in brain: pharmacological and functional studies

Massot, O.; Grimaldi, B.; Bailly, Jean-Marc; Kochanek, Magali; Deschamps, François; Lambrozo, Jacques; Fillion, G.

doi:10.1016/s0006-8993(99)02486-5

Cited by 46 publications

(39 citation statements)

References 40 publications

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“…Luben [17] pointed out that since low-energy EMF (pulse and direct current) has little energy to directly traverse the cell membrane, it is possible that it may modify the existing signal transduction processes in cell membrane, thus producing both transduction and biochemical amplification of the effects of the field itself. There is some evidence indicating that EMF affects intra-membrane protein distribution [18], phosphorylation [19], structural and biophysical changes in membranes [20], and desensitizes 5-HT(1B) receptor in brain [21]. Based on these data, we hypothesized that membrane proteins, especially receptors are the initial target sites of ELF-EMF.…”

Section: Introductionmentioning

confidence: 97%

An Incoherent Magnetic Field Inhibited EGF Receptor Clustering and Phosphorylation Induced by a 50-Hz Magnetic Field in Cultured FL Cells

Sun

Ye²,

Fu³

et al. 2008

Cell Physiol Biochem

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Previously, we found that exposure to a 50-Hz magnetic field (MF) at 0.4 mT could induce epidermal growth factor (EGF) receptor clustering in Chinese hamster lung (CHL) fibroblast cells and superposition of an incoherent MF with the same intensity could inhibit the effect. In the present experiment, we investigated the effects of 50-Hz MF exposure at different intensities on EGF receptor clustering and phosphorylation in human amniotic cells (FL), and explored the interaction effect of an incoherent MF. Clustering and phosphorylation of EGF receptors on cellular membrane surface were analyzed using immunofluorescence assessed by confocal microscopy and western blot technology, respectively. EGF treatment served as a positive control. The results showed that, compared with sham exposure, exposure to a 50-Hz MF at 0.1, 0.2 or 0.4 mT for 15 min could significantly induce EGF receptor clustering and enhance phosphorylation on tyrosine-1173 residue in FL cells, whereas exposure to a 0.05 mT field for 15 min did not caused a significant effect. Exposure to an incoherent MF (frequency range between 30 to 90 Hz) at 0.2 mT for the same time neither induced EGF receptor clustering nor enhanced phosphorylation of EGF receptor in FL cells. When superposed, the incoherent MF at 0.2 mT completely inhibited EGF receptor clustering and phosphorylation induced by a 50-Hz MF at 0.1 and 0.2 mT. However, the incoherent MF could not completely eliminate the effects induced by a 0.4 mT 50-Hz MF. Based on the results of this experiment, we conclude that membrane receptors could be one of the main targets where extremely-low frequency (ELF) MF interacts with cells, and the intensity threshold, in the case of EGF receptors, is between 0.05 and 0.1 mT. An incoherent MF could completely inhibit the effects induced by an ELF-MF of equal or lower intensity.

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Section: Introductionmentioning

confidence: 97%

An Incoherent Magnetic Field Inhibited EGF Receptor Clustering and Phosphorylation Induced by a 50-Hz Magnetic Field in Cultured FL Cells

Sun

Ye²,

Fu³

et al. 2008

Cell Physiol Biochem

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“…These changes include increased activity of hypothalamic and intracerebral nuclei, 3 changes in neurotransmitter synthesis in synapses and ganglia, 4 changes in the activity of neuronal receptors, including dopamine and 5-hydroxytryptamine-1B (5-HT1B), 5 and other changes that ultimately may affect learning and memory in organisms. 6,7 The effect of very low frequency of electromagnetic field (50HZ) with intensity of 0.5mT was examined on rats' brain structures-basal forebrain, hippocampus, frontal cortex, brainstem, and cerebellum-in long term exposure (7 days and totally 168 hours).…”

Section: 2mentioning

confidence: 99%

Brain Changes after Electromagnetic Fields Exposure

Forooz¹

2016

MOJT

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In recent years, extensive knowledge about the effect of electromagnetic fields has been gathered that provided different information in accordance with the frequency waves and the type of electromagnetic fields. The present study tries to review the effects of electromagnetic fields (EMF) on brain structure and the chemical mechanisms of neurons. Previous studies suggested that Brain Changes after Electromagnetic Fields Exposure are related to areas of frontal cortex, hippocampus, basal forebrain and brainstem. These structural changes can help us to understand changes in brain functions like learning and memory mechanisms especially those mechanisms that related to frontal cortex such as social recognition, active avoidance learning and Alzheimer's diseases.

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“…These changes include increased activity of hypothalamic and intra-cerebral nuclei [3], changes in neurotransmitter synthesis in synapses and ganglia [4], changes in the activity of neuronal receptors, including dopamine and 5-hydroxytryptamine-1B (5-HT1B) [5], and other changes that ultimately may affect learning and memory in organisms [6,7]. The effect of very low frequency of electromagnetic field (50HZ) with intensity of 0.5mT was examined on rats' brain structuresbasal forebrain, hippocampus, frontal cortex, brainstem, and cerebellum-in long term exposure (7 days and totally 168 hours).…”

Section: Introductionmentioning

confidence: 99%

Untitled

2016

MOJT

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Magnetic field desensitizes 5-HT1B receptor in brain: pharmacological and functional studies

Cited by 46 publications

References 40 publications

An Incoherent Magnetic Field Inhibited EGF Receptor Clustering and Phosphorylation Induced by a 50-Hz Magnetic Field in Cultured FL Cells

An Incoherent Magnetic Field Inhibited EGF Receptor Clustering and Phosphorylation Induced by a 50-Hz Magnetic Field in Cultured FL Cells

Brain Changes after Electromagnetic Fields Exposure

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