Magnetic field effects on spatial discrimination learning in mice

Resting brain metabolic activity in a 4 Tesla magnetic field

“…This is relevant because several studies have shown that fluctuating magnetic fields can influence brain activity (5,6). However, studies evaluating static magnetic fields are few, and though there is some evidence from animal studies that a field may interfere with performance of certain behavioral tasks (30), such an effect has not been corroborated in humans. Moreover, a recent study failed to detect any effect from an 8 T magnetic field on cognitive function in healthy human volunteers (7).…”

Decreased plasma levels of nitric oxide metabolites, angiotensin II, and aldosterone in spontaneously hypertensive rats exposed to 5 mT static magnetic field

“…There is substantial and growing evidence that static magnetic fields (SMF) less than 1 tesla (T) can influence physiological processes in vivo: pain [Takeshige and Sato, 1996;Vallbona et al, 1997;Holcomb et al, 2000;Brown et al, 2002;Hinman, 2002;Weintraub et al, 2003], bone repair and formation [Bruce et al, 1987;Mevissen et al, 1994;Darendeliler et al, 1997;Yan et al, 1998;Xu et al, 2001], inflammation and wound healing [Lud and Demeckiy, 1990;Weinberger et al, 1996;Man et al, 1999;Alfano et al, 2001;Segal et al, 2001;Rogachefsky et al, 2004], anticonvulsant effects [McLean et al, 2003], enhanced chemotherapy [Gray et al, 2000], spatial discrimination learning [Levine and Bluni, 1994], melatonin reduction [Welker et al, 1983;Olcese et al, 1985;Olcese and Reuss, 1986;Stehle et al, 1988], cyclic AMP reduction [Rudolph et al, 1988], central nervous system function [Rosen and Lubowsky, 1987;Veliks et al, 2004], action potential generation [Lohmann et al, 1991;Popescu and Willows, 1999;Wang et al, 2003Wang et al, , 2004, enhanced tumor apoptosis [Tofani et al, 2001[Tofani et al, , 2002, and increased c-fos gene expression [Němec et al, 2001]. Therefore, characterizing the physiological transduction mechanism of SMF on BP in both hypertension and hypotension, remains an important area of research toward the development of better p...…”

3 T homogeneous static magnetic field of a clinical MR significantly inhibits pain in mice

“…They found that the exposure caused a significant increase in the synthesis of the collageneous matrix of dentin in the incisors. Levine, Bluni and coworkers made efforts (Levine and Bluni, 1994;Levine et al, 1995) to reveal the effect of 0.3 and 2 T homogeneous SMF of an MR on the left and right discrimination learning ability and the serum melatonin levels of mice with exposure durations of 30 to 100 min. They found a significant interference of SMF with spatial discrimination learning, but no influence of SMF on serum melatonin levels.…”