2014
DOI: 10.1021/nn405520d
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Magnetic Field-Induced T Cell Receptor Clustering by Nanoparticles Enhances T Cell Activation and Stimulates Antitumor Activity

Abstract: Iron–dextran nanoparticles functionalized with T cell activating proteins have been used to study T cell receptor (TCR) signaling. However, nanoparticle triggering of membrane receptors is poorly understood and may be sensitive to physiologically regulated changes in TCR clustering that occur after T cell activation. Nano-aAPC bound 2-fold more TCR on activated T cells, which have clustered TCR, than on naive T cells, resulting in a lower threshold for activation. To enhance T cell activation, a magnetic field… Show more

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Cited by 203 publications
(202 citation statements)
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“…Cho et al applied a static magnetic field (0.2 T) to aggregate MNPs bound death receptor 4, which then promotes apoptosis signaling pathways [50]. Perica et al modified MNPs by T cell activating proteins to be artificial antigen presenting cells; when applying a magnetic field (0.15 T) the aggregation of MNPs resulted in the activation and expansion of T cells [51]. As shown in Table 2, we have also summarized other studies where mechanical force was used to regulate cells.…”
Section: Under Constant or Low Frequency Magnetic Fieldmentioning
confidence: 99%
“…Cho et al applied a static magnetic field (0.2 T) to aggregate MNPs bound death receptor 4, which then promotes apoptosis signaling pathways [50]. Perica et al modified MNPs by T cell activating proteins to be artificial antigen presenting cells; when applying a magnetic field (0.15 T) the aggregation of MNPs resulted in the activation and expansion of T cells [51]. As shown in Table 2, we have also summarized other studies where mechanical force was used to regulate cells.…”
Section: Under Constant or Low Frequency Magnetic Fieldmentioning
confidence: 99%
“…[89] In this direction, as an artificial APC, sub 100 nm sized iron oxide nanoparticles coated with dextran and conjugated with stimulatory molecules have shown to induce the T-cell receptor clustering under magnetic field and activate näive T cells. [90] More details on various nanoparticles strategies developed for cancer immunotherapy have been extensively reviewed elsewhere. [15,85,91] …”
Section: Next Generation Nanomedicinesmentioning
confidence: 99%
“…Ex vivo stimulation of T cells with these particles in the presence of a magnetic fieldenhanced TCR clustering reduced the threshold of activation of T cells and improved the efficacy of adaptive T cell therapy. 81 Moreover, nanotechnology opens the door for the in vivo targeting, priming and expansion of T cells. For example, in vivo loading of T cells with lipid nanoparticle ''backpacks'' carrying stimulatory cytokines was demonstrated.…”
Section: Nanocarriers To Deliver Tumor Microenvironment Immunomodulatorsmentioning
confidence: 99%