Magnetic fields enhance the anti-tumor efficacy of low dose cisplatin and reduce the nephrotoxicity

Rageh, Monira M.; El-Garhy, Marwa R.; Mohamad, Ebtesam A.

doi:10.1007/s00210-020-01855-9

Cited by 14 publications

(7 citation statements)

References 55 publications

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“…Paraffin-embedded sections of the solid EAC tumor, right thigh muscles of normal control, liver, and kidneys were sliced into a thickness of (4−5 μm) and stained with hematoxylin and eosin (H&E) solution and examined under a light microscope. 81 Statistical Analysis. All values in vivo results were presented as mean ± standard error of the mean To evaluate the significance of the difference between treatments, one-way ANOVA was used, followed by the Tukey−Kramer multiple comparisons test.…”

Section: ■ Discussionmentioning

confidence: 99%

“…Following necropsy, the liver, kidneys, and Ehrlich solid tumors (EST) were immediately removed and preserved in 10% buffered neutral formalin for histological analysis. Paraffin-embedded sections of the solid EAC tumor, right thigh muscles of normal control, liver, and kidneys were sliced into a thickness of (4–5 μm) and stained with hematoxylin and eosin (H&E) solution and examined under a light microscope …”

Section: Experimental Sectionmentioning

confidence: 99%

“…Paraffin-embedded sections of the solid EAC tumor, right thigh muscles of normal control, liver, and kidneys were sliced into a thickness of (4–5 μm) and stained with hematoxylin and eosin (H&E) solution and examined under a light microscope. 81 …”

Section: Experimental Sectionmentioning

confidence: 99%

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Annona squamosa L. Extract-Loaded Niosome and Its Anti-Ehrlich Ascites’ Carcinoma Activity

et al. 2022

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Current research is focused on cancer treatments other than chemotherapy medications, particularly those derived from natural sources. The goal of this work was to look at the anticancer and biomarker properties of a methanolic extract of Annona squamosa leaves and their extract-loaded noisome. A. squamosa leaves extract and their leaves extract-loaded noisome were prepared. Transmission electron microscopy was used to screen the size of the niosomes loaded with the A. squamosa L. leaves extract. The tumor size, blood picture (hemoglobin, red blood cells, white blood cells), liver functions, kidney function, oxidative stress, and inflammatory markers were evaluated to assess the potential anticancer activity of the A. squamosa leaves extract and A. squamosa leaves extract-loaded noisome in Ehrlich ascites carcinoma. A. squamosa L. leaves extract was found to be an effective anticancer treatment. The protective effect of the loaded extract showed more significant results. All treated groups showed a lower tumor volume compared to the positive control. Liver and kidney functions were improved, and inflammatory markers were decreased. Oxidative stress was improved in tumor, liver, and kidney tissues. A. squamosa leaves contain major anticancer compounds that in general help most enzymes of the liver and kidney and other injured organs to return to their normal levels.

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Section: ■ Discussionmentioning

confidence: 99%

Section: Experimental Sectionmentioning

confidence: 99%

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Annona squamosa L. Extract-Loaded Niosome and Its Anti-Ehrlich Ascites’ Carcinoma Activity

et al. 2022

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“…After the end of the experiment, skin tissues of the groups were placed in 10% neutral formalin. Later, tissues were inserted in paraffin and divided by microtone then stained with hematoxylin and eosin (H&E) [18,19]. Tissues were observed by a light microscope (BX50, Olympus microscope, Tokyo, Japan).…”

Section: Histopathological Studymentioning

confidence: 99%

Curcumin provides skin Protection against UV radiation

Rageh

Ahmed

2023

Egypt. J. Chem.

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The aim of this study is to evaluate the UV-protective activity of nano-curcumin in a rat skin model and compare its results with a commercial sunscreen agent, phenylbenzimidazole-5-sulfonic acid (PBSA). Nano-curcumin were prepared and characterized by measuring their size distribution. The photoprotective potential was evaluated by histopathological examination of the skin. Results showed that skin group irradiated with UV showed a significant histopathological change, it showed skin thickening and necrosis of dermal collagen. On the other hand, treatment with nano-curcumin protected skin tissues against UV damage by restoring histopathology changes. The results revealed that nano-curcumin provide a significant protection to the skin tissues in comparison with conventional treatment by PBSA.

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“…A comet test is a sensitive technique for determining DNA damage (Rageh et al, 2020). The comet test was conducted to identify and compare DNA damage to tumor tissues in the treated and control groups.…”

Section: Comet Assaymentioning

confidence: 99%

Antitumor impact of iron oxide nanoparticles in Ehrlich carcinoma-bearing mice

Abd-Elghany

Mohamad

2021

Journal of Radiation Research and Applied Sciences

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Magnetic nanoparticles are promising approaches for cancer treatment. Iron oxide nanoparticles have been pre-formed by the co-precipitation method to investigate their antitumor activity on Ehrlich carcinoma in mice. The nanoparticles have been studied by UV spectrophotometer, transmission electron microscopy, dynamic light scattering, and zeta potential measurement. To determine the therapeutic impact of Iron oxide nanoparticles in tumorbearing mice, in vivo experiments were carried out. Fourier Transform Infra-red (FTIR) spectroscopy and DNA comet assay were used to estimate the toxicity of nanoparticles of iron oxide. The tissue was analyzed using FTIR spectral parameters such as the area beneath the peak, peak position, and peak intensity. The results showed that iron oxide nanoparticles significantly led to antitumor activity against Ehrlich carcinoma. There was a low shift in position and intensity at the amide I band (1650 cm −1 ) in tissues of mice treated with iron oxide nanoparticles compared to the control group. Comet examination showed a decrease across all the parameters of the assay (tail moment, tail DNA percentage, and tail length) in the tumor + iron nanoparticles group, having values lower than the tumor group. According to the presented results, Iron oxide nanoparticles have exhibited therapeutic efficacy against cancer.

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Magnetic fields enhance the anti-tumor efficacy of low dose cisplatin and reduce the nephrotoxicity

Cited by 14 publications

References 55 publications

Annona squamosa L. Extract-Loaded Niosome and Its Anti-Ehrlich Ascites’ Carcinoma Activity

Annona squamosa L. Extract-Loaded Niosome and Its Anti-Ehrlich Ascites’ Carcinoma Activity

Curcumin provides skin Protection against UV radiation

Antitumor impact of iron oxide nanoparticles in Ehrlich carcinoma-bearing mice

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