Magnetic Graphene Oxide Nanocarrier for Targeted Delivery of Cisplatin: A Perspective for Glioblastoma Treatment

Abstract

Selective vectorization of Cisplatin (CisPt) to Glioblastoma U87 cells was exploited by the fabrication of a hybrid nanocarrier composed of magnetic γ-Fe2O3 nanoparticles and nanographene oxide (NGO). The magnetic component, obtained by annealing magnetite Fe3O4 and characterized by XRD measurements, was combined with NGO sheets prepared via a modified Hummer’s method. The morphological and thermogravimetric analysis proved the effective binding of γ-Fe2O3 nanoparticles onto NGO layers. The magnetization measured under magnetic fields up to 7 Tesla at room temperature revealed superparamagnetic-like behavior with a maximum value of MS = 15 emu/g and coercivity HC ≈ 0 Oe within experimental error. The nanohybrid was found to possess high affinity towards CisPt, and a rather slow fractional release profile of 80% after 250 h. Negligible toxicity was observed for empty nanoparticles, while the retainment of CisPt anticancer activity upon loading into the carrier was observed, together with the possibility to spatially control the drug delivery at a target site.

Synthesis of Graphene Oxide-Fe3O4 Based Nanocomposites Using the Mechanochemical Method and in Vitro Magnetic Hyperthermia

“…Graphene oxide-Fe 3 O 4 nanoparticle-based nanocomposites are widely investigated for various biomedical applications, like drug delivery, magnetic hyperthermia, and MRI (Magnetic Resonance Imaging) contrast agents [1,2,3,4,5]. Unique chemical and physical properties of graphene oxide-based nanocomposites enables us to design and engineer their structure as per requirements [6].…”

Natural Polysaccharide Carriers in Brain Delivery: Challenge and Perspective

“…In stimuli-responsive targeting (also known as tertiary targeting), the vectorization is triggered by physiological or pathological signals within the site of interest, which induce nanocarrier structural modifications and payload release [56]. The variation of pH, temperature and redox potential, together with the overproduction of reactive oxygen species (ROS), represent the most common endogenous signals, whereas the application of ultrasound, electric and magnetic fields is classified as exogenous stimuli [57][58][59][60][61]. Focalized ultrasound has been used in the clinic because of encouraging localized bio-effects in preclinical models, but is also emerging as a valuable strategy for increasing vascular permeability and improve the therapeutics delivery in a nondestructive manner [62].…”

Superparamagnetic Fe/Au Nanoparticles and Their Feasibility for Magnetic Hyperthermia

“…Recently, many attempts have been made to develop a large number of biocompatible superparamagnetic nanoparticles such as ferrites (MFe 2 O 4 where M=Fe, Mn, Co, Ni, Zn) that have a large spectrum of magnetic characteristics [9][10][11][12]. Multifunctional nanocomposite surfaces can be used like a bio-functional stage for drug delivery [13,14]. Recent reports showed that to cause direct cellular death in tumors, the induced heating power under therapeutic magnetic field and frequency should produce localized heating up to 50 • C [5,15].…”