Magnetic hydroxyapatite nanocomposites: The advances from synthesis to biomedical applications

Mushtaq, Asim; Zhao, Ruibo; Luo, Dandan; Dempsey, Eithne; Wang, Xiumei; Iqbal, M. Zubair; Kong, Xiangdong

doi:10.1016/j.matdes.2020.109269

Cited by 55 publications

(30 citation statements)

References 120 publications

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“…Additionally, nHAp has aroused extensive interest in drug delivery research due to its high biocompatibility, low cytotoxicity, better biodegradability, and favorable affinity to plenty of molecules such as chemotherapy drugs, pDNA, and siRNA. In particular, it gained remarkable potential as a gene delivery system in tumor treatment and therapy [ 26 ]. Gu et al [ 27 ] reported that the NR2B siRNA-loaded HAp nanoparticle could not only eliminate the formalin-induced tetanic response but also significantly downregulate the expression of NR2B protein in mice.…”

Section: Introductionmentioning

confidence: 99%

siRNA-Loaded Hydroxyapatite Nanoparticles for KRAS Gene Silencing in Anti-Pancreatic Cancer Therapy

Luo

Iqbal

et al. 2021

Pharmaceutics

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Pancreatic carcinoma (PC) is greatly induced by the KRAS gene mutation, but effective targeted delivery for gene therapy has not existed. Small interfering ribonucleic acid (siRNA) serves as an advanced therapeutic modality and holds great promise for cancer treatment. However, the development of a non-toxic and high-efficiency carrier system to accurately deliver siRNA into cells for siRNA-targeted gene silencing is still a prodigious challenge. Herein, polyethylenimine (PEI)-modified hydroxyapatite (HAp) nanoparticles (HAp-PEI) were fabricated. The siRNA of the KRAS gene (siKras) was loaded onto the surface of HAp-PEI via electrostatic interaction between siRNA and PEI to design the functionalized HAp-PEI nanoparticle (HAp-PEI/siKras). The HAp-PEI/siKras was internalized into the human PC cells PANC-1 to achieve the maximum transfection efficiency for active tumor targeting. HAp-PEI/siKras effectively knocked down the expression of the KRAS gene and downregulated the expression of the Kras protein in vitro. Furthermore, the treatment with HAp-PEI/siKras resulted in greater anti-PC cells’ (PANC-1, BXPC-3, and CFPAC-1) efficacy in vitro. Additionally, the HAp-PEI exhibited no obvious in vitro cytotoxicity in normal pancreatic HPDE6-C7 cells. These findings provided a promising alternative for the therapeutic route of siRNA-targeted gene engineering for anti-pancreatic cancer therapy.

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Section: Introductionmentioning

confidence: 99%

siRNA-Loaded Hydroxyapatite Nanoparticles for KRAS Gene Silencing in Anti-Pancreatic Cancer Therapy

Luo

Iqbal

et al. 2021

Pharmaceutics

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“…Magnetic nanocomposite materials serve multifunctional purposes in the field of catalysis, colloidal photonic crystals, imaging, nanofluids, data storage, defect sensor, optical filters, environmental remediation, and, in particular, in the biomedical industry because of their unique mechanical, thermal, physical, and chemical properties [ 47 ]. The research in the field of hydroxyapatite nanocomposites is still in its infancy and requires controlling fabrication processes for advanced applications.…”

Section: Resultsmentioning

confidence: 99%

Enhancement of Anticorrosive Performance of Cardanol Based Polyurethane Coatings by Incorporating Magnetic Hydroxyapatite Nanoparticles

et al. 2022

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The present investigation demonstrates renewable cardanol-based polyol for the formulation of nanocomposite polyurethane (PU) coatings. The functional and structural features of cardanol polyol and nanoparticles were studied using FT-IR and 1H NMR spectroscopic techniques. The magnetic hydroxyapatite nanoparticles (MHAPs) were dispersed 1–5% in PU formulations to develop nanocomposite anticorrosive coatings. An increase in the strength of MHAP increased the anticorrosive performance as examined by immersion and electrochemical methods. The nanocomposite PU coatings showed good coating properties, viz., gloss, pencil hardness, flexibility, cross-cut adhesion, and chemical resistance. Additionally, the coatings were also studied for surface morphology, wetting, and thermal properties by scanning electron microscope (SEM), contact angle, and thermogravimetric analysis (TGA), respectively. The hydrophobic nature of PU coatings increased by the addition of MHAP, and an optimum result (105°) was observed in 3% loading. The developed coatings revealed its hydrophobic nature with excellent anticorrosive performance.

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“…A comprehensive review of the current issues of preparation and properties of magnetic HA and the application of these NCP materials in biomedicine as implants for bone regeneration with antimicrobial activity, controlled drug/gene delivery, and magnetic hyperthermia treatment was recently published by Mushtaq et al [124]. Additionally, Scialla et al [125] obtained positive results of the use of a NCP composed of magnetic iron oxide grafted with dextran in combination with nHA in bone tissue engineering [125].…”

Section: Metal Doped Hydroxyapatitementioning

confidence: 99%

Advances in Use of Nanomaterials for Musculoskeletal Regeneration

Jampílek

Plachá

2021

Pharmaceutics

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Since the worldwide incidence of bone disorders and cartilage damage has been increasing and traditional therapy has reached its limits, nanomaterials can provide a new strategy in the regeneration of bones and cartilage. The nanoscale modifies the properties of materials, and many of the recently prepared nanocomposites can be used in tissue engineering as scaffolds for the development of biomimetic materials involved in the repair and healing of damaged tissues and organs. In addition, some nanomaterials represent a noteworthy alternative for treatment and alleviating inflammation or infections caused by microbial pathogens. On the other hand, some nanomaterials induce inflammation processes, especially by the generation of reactive oxygen species. Therefore, it is necessary to know and understand their effects in living systems and use surface modifications to prevent these negative effects. This contribution is focused on nanostructured scaffolds, providing a closer structural support approximation to native tissue architecture for cells and regulating cell proliferation, differentiation, and migration, which results in cartilage and bone healing and regeneration.

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Magnetic hydroxyapatite nanocomposites: The advances from synthesis to biomedical applications

Cited by 55 publications

References 120 publications

siRNA-Loaded Hydroxyapatite Nanoparticles for KRAS Gene Silencing in Anti-Pancreatic Cancer Therapy

siRNA-Loaded Hydroxyapatite Nanoparticles for KRAS Gene Silencing in Anti-Pancreatic Cancer Therapy

Enhancement of Anticorrosive Performance of Cardanol Based Polyurethane Coatings by Incorporating Magnetic Hydroxyapatite Nanoparticles

Advances in Use of Nanomaterials for Musculoskeletal Regeneration

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