Magnetic hyperthermia in phosphate coated iron oxide nanofluids

Lahiri, B.B.; Muthukumaran, T.; Philip, John

doi:10.1016/j.jmmm.2016.01.044

Cited by 97 publications

(32 citation statements)

References 72 publications

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“…A similar decreasing trend is observed for the other H × f values as well, which could be mainly ascribed to more agglomerations at higher concentrations due to increased interparticle interactions between the SPIOs, which might have led to the formation of very long linear-chain structures inside the aqueous suspensions and subsequent reductions in their Brownian relaxations. 32 − 35 …”

Section: Resultsmentioning

confidence: 99%

Functionalized Hydrophilic Superparamagnetic Iron Oxide Nanoparticles for Magnetic Fluid Hyperthermia Application in Liver Cancer Treatment

Kandasamy¹,

Sudame²,

Luthra³

et al. 2018

ACS Omega

141

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In this work, we report the synthesis of hydrophilic and surface-functionalized superparamagnetic iron oxide nanoparticles (SPIOs) to utilize them as nanomedicines for treating liver cancer via magnetic fluid hyperthermia (MFH)-based thermotherapy. For this purpose, initially, we have synthesized the SPIOs through co-precipitation/thermolysis methods, followed by in situ surface functionalization with short-chained molecules, such as 1,4-diaminobenzene (14DAB), 4-aminobenzoic acid (4ABA) and 3,4-diaminobenzoic acid (34DABA) and their combination with terephthalic acid (TA)/2-aminoterephthalic acid (ATA)/trimesic acid (TMA)/pyromellitic acid (PMA) molecules. The as-prepared SPIOs are investigated for their structure, morphology, water dispersibility, and magnetic properties. The heating efficacies of the SPIOs are studied in calorimetric MFH (C-MFH) with respect to their concentrations, surface coatings, dispersion medium, and applied alternating magnetic fields (AMFs). Although all of the as-prepared SPIOs have exhibited superparamagnetic behavior, only 14DAB-, 4ABA-, 34DABA-, and 4ABA-TA-coated SPIOs have shown higher magnetization values (Ms = 55–71 emu g–1) and good water dispersibility. In C-MFH studies, 34DABA-coated SPIO-based aqueous ferrofluid (AFF) has revealed faster thermal response to the applied AMF and reached therapeutic temperature even at the lowest concentration (0.5 mg mL–1) compared with 14DAB-, 4ABA-, and 4ABA-TA-coated SPIO-based AFFs. Moreover, 34DABA-coated SPIO-based AFF has exhibited high heating efficacies (i.e., specific absorption rate/intrinsic loss power values of 432.1 W gFe–1/5.2 nHm2 kg–1 at 0.5 mg mL–1), which could be mainly due to (i) enhanced π–π conjugation paths of surface-attached 34DABA coating molecules because of intrafunctional group attractions and (ii) improved anisotropy from the formation of clusters/linear chains of the SPIOs in ferrofluid suspensions, owing to interfunctional group attractions/interparticle interactions. Moreover, the 34DABA-coated SPIOs have demonstrated (i) very good cytocompatibility for 24/48 h incubation periods and (ii) higher killing efficiency of 61–88% (via MFH) in HepG2 liver cancer cells as compared to their treatment with only AMF/water-bath-based thermotherapy. In summary, the 34DABA-coated SPIOs are very promising heat-inducing agents for MFH-based thermotherapy and thus could be used as effective nanomedicines for cancer treatments.

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Section: Resultsmentioning

confidence: 99%

Functionalized Hydrophilic Superparamagnetic Iron Oxide Nanoparticles for Magnetic Fluid Hyperthermia Application in Liver Cancer Treatment

Kandasamy¹,

Sudame²,

Luthra³

et al. 2018

ACS Omega

141

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“…where h is the heat transfer coefficient 10[W/(m 2 •K)], T air is the temperature of the surrounding air 293. 15 [K] and k thermal conductivity 0.52[W/(m•K)].…”

Section: Equations Descrining Fields Distributionmentioning

confidence: 99%

Analysis of electromagnetic heating in magnetic fluid deep hyperthermia

Kurgan¹,

Gas²

2018

EasyChair Preprints

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In this paper, we describe the numerical modeling of magnetically induced heating of tissues in magnetic fluid deep hyperthermia. When placed in sinusoidal varying electromagnetic field, the Brownian particle rotation and Neel relaxation mechanisms induce in ferrofluid heat generation. In order to destroy tumors cells while preventing healthy tissues, such parameters as susceptibility of nanoparticles, exciting current parameters and intensity of magnetic fields should be calculated precisely. In this publication, coupled field problem resulting from Maxwell's equation and Penne's bioheat equation is discussed. Both sets of equations are solved using the finite element analysis method. We use a simplify model of human thorax with blood perfusion mechanism and tumor placed in it. Heat generation source in tumor is obtained by ferromagnetic nanoparticles. Magnetic and temperature field distribution is discussed in context of optimal tumor treatment.

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“…2,3 Temperature between 42-46 o C induce changes in the protein metabolism that may finally result in cellular degradation and apoptosis of the cancer cells while causing minimal damage to the surrounding healthy cells. 4 Hyperthermia treatment is usually used in combination with other cancer therapy options such as radiotherapy or chemotherapy because the simultaneous delivery of heat and radionuclides/drugs is much more effective in achieving therapeutic effects. 5 Furthermore, multifunctional radiolabeled MNPs nanoparticles with the capability of detecting and destroying of cancer cells with the potential for the visualization of therapy have been considered as the best choice for the application in cancer therapy.…”

Section: Introductionmentioning

confidence: 99%