Magnetic ion-exchange nano- and microparticles for medical, biochemical and molecular biological applications

Bergemann, Ch.; Müller-Schulte, Detlef; Oster, Jürgen; Brassard, L à; Lübbe, Andreas S.

doi:10.1016/s0304-8853(98)00554-x

Cited by 257 publications

(144 citation statements)

References 8 publications

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“…These nanoparticular materials often exhibit very interesting electrical, optical, magnetic, and chemical properties, which cannot be achieved by their bulk counterparts. In literature, polymers such as dextran, PVA, and DEAE-starch were added to coat the particles for better stability, before or after the formation of iron oxide particles [80,81]. Otherwise, magnetic nanoparticles can be coated with silica containing a high coverage of silanol groups, which can easily be anchored with defined and generic surface chemistries [82,83].…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Enzyme immobilization: an update

et al. 2013

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Compared to free enzymes in solution, immobilized enzymes are more robust and more resistant to environmental changes. More importantly, the heterogeneity of the immobilized enzyme systems allows an easy recovery of both enzymes and products, multiple re-use of enzymes, continuous operation of enzymatic processes, rapid termination of reactions, and greater variety of bioreactor designs. This paper is a review of the recent literatures on enzyme immobilization by various techniques, the need for immobilization and different applications in industry, covering the last two decades. The most recent papers, patents, and reviews on immobilization strategies and application are reviewed.

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Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Enzyme immobilization: an update

et al. 2013

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“…The synthesis and applications of (nonmagnetic) polymer microparticles were reviewed by Kawaguchi (2000). The articles of Landfester and Ramirez (2003), Bergemann et al (1999), and Gruttner et al (2001) present specific short review sections on the synthesis and chemical modifications of magnetic beads. The synthesis of magnetic beads is also a well covered subject in the patent literature.…”

Section: Synthesismentioning

confidence: 99%

Magnetic bead handling on-chip: new opportunities for analytical applications

Gijs

2004

Microfluid Nanofluid

497

555

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This review describes recent advances in the handling and manipulation of magnetic particles in microfluidic systems. Starting from the properties of magnetic nanoparticles and microparticles, their use in magnetic separation, immuno-assays, magnetic resonance imaging, drug delivery, and hyperthermia is discussed. We then focus on new developments in magnetic manipulation, separation, transport, and detection of magnetic microparticles and nanoparticles in microfluidic systems, pointing out the advantages and prospects of these concepts for future analysis applications.

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“…The synthesis of biocompatible superparamagnetic materials has long been of interest in biomedical applications including magnetic resonance imaging for clinical diagnosis, magnetic drug targeting, hyperthermia anti-cancer strategy, and enzyme immobilization (Kim et al, 2001;Reynolds et al, 2000;Lubbe et al, 1996;Bergemann et al, 1999;Chan et al, 1993;Jordan et al, 1999;Dyal et al, 2003). Entrapment techniques using liposomes, alginate and some other biopolymers are usually applied for different clinical procedures such as drugs release, hyperthermia or for local contrast enhancement in MR imaging.…”

Section: Introductionmentioning

confidence: 99%

Ca alginate as scaffold for iron oxide nanoparticles synthesis

Finotelli

Sampaio

Morales

et al. 2008

Braz. J. Chem. Eng.

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-Recently, nanotechnology has developed to a stage that makes it possible to process magnetic nanoparticles for the site-specific delivery of drugs. To this end, it has been proposed as biomaterial for drug delivery system in which the drug release rates would be activated by a magnetic external stimuli. Alginate has been used extensively in the food, pharmaceutical and biomedical industries for their gel forming properties in the presence of multivalent cations. In this study, we produced iron oxide nanoparticles by coprecipitation of Fe(III) and Fe(II). The nanoparticles were entrapped in Ca alginate beads before and after alginate gelation. XRD analysis showed that particles should be associated to magnetite or maghemite with crystal size of 9.5 and 4.3 nm, respectively. Studies using Mössbauer spectroscopy corroborate the superparamagnetic behavior. The combination of magnetic properties and the biocompatibility of alginate suggest that this biomaterial may be used as biomimetic system.

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Magnetic ion-exchange nano- and microparticles for medical, biochemical and molecular biological applications

Cited by 257 publications

References 8 publications

Enzyme immobilization: an update

Enzyme immobilization: an update

Magnetic bead handling on-chip: new opportunities for analytical applications

Ca alginate as scaffold for iron oxide nanoparticles synthesis

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