Magnetic liposome design for drug release systems responsive to super-low frequency alternating current magnetic field (AC MF)

Vlasova, Kseniya Yu.; Piroyan, Alexander; Le-Deygen, Irina M.; Vishwasrao, Hemant M.; Ramsey, Jacob D.; Klyachko, Natalia L.; Golovin, Yuri I.; Rudakovskaya, Polina G.; Kireev, Igor I.; Kabanov, Alexander V.; Klyachko, N. L.

doi:10.1016/j.jcis.2019.05.071

Cited by 55 publications

(28 citation statements)

References 42 publications

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“…The hydrophobic tails of phospholipid molecules tend to gather to avoid the water, while the hydrophilic heads are exposed to the water phase and form closed vesicles with a bilayer structure. Liposomes have been widely utilized in the drug delivery system since the 1960s owing to their excellent targeting, stability, biocompatibility and ease of modification [50,51]. With the development of hollow structure, liposomes have drawn more attention from researchers.…”

Section: Liposomementioning

confidence: 99%

Hollow structures as drug carriers: Recognition, response, and release

Zhao

Yang

et al. 2021

Nano Res.

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Hollow structures have demonstrated great potential in drug delivery owing to their privileged structure, such as high surface-to-volume ratio, low density, large cavities, and hierarchical pores. In this review, we provide a comprehensive overview of hollow structured materials applied in targeting recognition, smart response, and drug release, and we have addressed the possible chemical factors and reactions in these three processes. The advantages of hollow nanostructures are summarized as follows: hollow cavity contributes to large loading capacity; a tailored structure helps controllable drug release; variable compounds adapt to flexible application; surface modification facilitates smart responsive release. Especially, because the multiple physical barriers and chemical interactions can be induced by multishells, hollow multishelled structure is considered as a promising material with unique loading and releasing properties. Finally, we conclude this review with some perspectives on the future research and development of the hollow structures as drug carriers.

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Section: Liposomementioning

confidence: 99%

Hollow structures as drug carriers: Recognition, response, and release

Zhao

Yang

et al. 2021

Nano Res.

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“…Broadly, the application of ultrasound for liposomal drug release relies on i) thermally triggered release and, ii) nonthermal membrane disruption. [152] Other stimuli include high frequency and low frequency magnetic fields, [153][154][155] NIR, [156][157][158] and UV radiation. [159,160] Various stimuli-responsive liposome constructs can release encapsulated content under external effects, whether they are composed of susceptible lipids, polymers, or other agents and particles.…”

Section: Stimuli Responsive Liposomesmentioning

confidence: 99%

“…Broadly, the application of ultrasound for liposomal drug release relies on i) thermally triggered release and, ii) non‐thermal membrane disruption. [ 152 ] Other stimuli include high frequency and low frequency magnetic fields, [ 153 , 154 , 155 ] NIR, [ 156 , 157 , 158 ] and UV radiation. [ 159 , 160 ]…”

Section: Drug Delivery Systems and Droplet‐based Technologymentioning

confidence: 99%

Droplet Microfluidics for Tumor Drug‐Related Studies and Programmable Artificial Cells

Dimitriou

Tornillo

et al. 2021

Global Challenges

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(1 of 17)www.global-challenges.com robotics, have promoted the use of in vitro tumor models in high-throughput drug screenings. [2,3] High-throughput screens for anticancer drugs have been, for a long time, limited to 2D culture of tumor cells, grown as a monolayer on the bottom of a well of a microtiter plate. Compared to 2D cell cultures, 3D culture systems can more faithfully model cell-cell interactions, matrix deposition and tumor microenvironments, including more physiological flow conditions, oxygen and nutrient gradients. [4] Therefore, 3D cultures have recently begun to be incorporated into high-throughput drug screenings, with the aim of better predicting drug efficacy and improving the prioritization of candidate drugs for further in vivo testing in animals.Because of the relatively simple, reproducible, amenable to automation and scalable culture methods, single-cell type and mixed-cell tumor spheroids, known as multicellular tumor spheroids (MCTSs), are used as 3D models. [5] There exists a broad range of natural hydrogels that are compatible with microfluidics, and which provide cancer cells with mechanical cues and adhesion sites to proliferate and grow into MCTSs. [6] With the aid of microfluidics and development of more complex 3D tumor models, [7,8] and the large-scale production of tumor spheroids in hydrogels, the number of compounds that could progress to in vivo testing could be restricted, thus reducing the number of animals needed for preclinical studies.Tumor-targeted drug delivery using microparticles and liposomes is beneficial compared to conventional drug administration. This is because encapsulated drug dosages can be controlled, healthy tissues can remain unharmed during treatment and drug resistance of cancer cells may be reduced/ prevented. [9,10] Microparticles and liposomes can be tailored to specifically target tumor sites using molecular conjugates, while avoiding toxic effects. [9] This review discusses the application of droplet-based microfluidic technologies for the development of accurate in vitro tumor models and improved cancer treatment strategies. The first part of the review centers around the generation of MCTSs in natural hydrogels for a better recapitulation of the in vivo tumor microenvironment. The second section is focused on microparticle and liposomal production for tumor-targeted drug delivery. Emphases is given to microfluidic methodologies for the production of these systems, and the potential of compartmentalized artificial cells as anticancer drug screening platforms.

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“…The phase analysis of the MNPs was carried out as described previously 38 using a custom-made Mössbauer spectrometer (Faculty of Chemistry, M. V. Lomonosov Moscow State University), equipped with a nitrogen cryostat, and a moving source of 57Co(Rh) with activity 1.8 × 109 Bq at RT.…”

Section: Materials Characterizationmentioning

confidence: 99%

Enzyme Release from Polyion Complex by Extremely Low Frequency Magnetic Field

Vlasova

Vishwasrao

Abakumov

et al. 2020

Sci Rep

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Remote nano-magneto-mechanical actuation of magnetic nanoparticles (Mnps) by non-heating extremely low frequency magnetic field (ELF MF) is explored as a tool for non-invasive modificationof bionanomaterials in pharmaceutical and medical applications. Here we study the effects of ELF MF (30-160 Hz, 8-120 kA/m) on the activity and release of a model enzyme, superoxide dismutase 1 (SOD1) immobilized by polyion coupling on dispersed Mnps aggregates coated with poly(L-lysine)-blockpoly(ethylene glycol) block copolymer (s-MNPs). Such fields do not cause any considerable heating of Mnps but promote their rotating-oscillating mechanical motion that produces mechanical forces and deformations in adjacent materials. We observed the changes in the catalytic activity of immobilized SOD1 as well as its release from the s-MNPs/SOD1 polyion complex upon application of the ELF MF for 5 to 15 min. At longer exposures (25 min) the s-MNPs/SOD1 dispersion destabilizes. The bell-shaped effect of the field frequency with maximum at f = 50 Hz and saturation effect of field strength (between 30 kA/m and 120 kA/m at f = 50 Hz) are reported and explained. The findings are significant as one early indication of the nano-magneto-mechanical disruption by eLf Mf of cooperative polyion complexes that are widely used for design of current functional healthcare bionanomaterials.Non-invasive functional control of bionanomaterials in inaccessible areas of a human body (e.g., biochemical reactions, drug release, gene expression, etc.) could greatly advance development of diagnostics and therapeutic modalities 1 . This control can be accomplished by remote actuation of nanoparticles by external fields 2-6 . In recent years magnetic nanoparticles (MNPs) have been investigated for cell separation, targeted drug delivery, and magnetic resonance imaging (MRI) 7-9 . Remote actuation of MNPs by radio frequency (200-800 kHz) magnetic fields has been used in hyperthermia for cancer therapy 10-12 . However, this approach has a risk of tissue overheating and damage. Recently an alternative nano-magneto-mechanical actuation of MNPs by non-heating extremely low frequency magnetic field (ELF MF) has attracted increasing attention in drug delivery and nanomedicine [13][14][15][16][17] .The phenomenon of nano-magneto-mechanical actuation is linked to the ability of MNPs to undergo mechanical motion in ELF MF and as a consequence produce mechanical forces and deformations in adjacent materials. It is well known, that a single-domain MNPs can relax in an external magnetic field, reducing an angle between the MNPs magnetic moment μ and the field vector H [18][19][20] . Two basic types of relaxation phenomena are dependent on the size of the magnetic core. MNPs with D m less than some critical value d* experience rotation of magnetic moments μ towards the vector H, which proceeds mainly by overcoming the crystallographic anisotropy of the lattice, without causing significant mechanical motion of the particle (Néel relaxation). MNPs with a diameter D m greater than d*...

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Magnetic liposome design for drug release systems responsive to super-low frequency alternating current magnetic field (AC MF)

Cited by 55 publications

References 42 publications

Hollow structures as drug carriers: Recognition, response, and release

Hollow structures as drug carriers: Recognition, response, and release

Droplet Microfluidics for Tumor Drug‐Related Studies and Programmable Artificial Cells

Enzyme Release from Polyion Complex by Extremely Low Frequency Magnetic Field

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