Magnetic Maghemite Nanoparticles

Magnetic Iron Oxide Nanoparticles: Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications

“…The grafting of vector molecules on the particles can also be performed with 2,3-dimercaptosuccinic acid (DMSA) and N-succinimidyl 3-(2-pyridyldithio)propionate (SPDP). 506 In this case, the nanoparticular system is constituted by two subunits, the particle coated with the chelating agent DMSA and the vector linked to SPDP through a peptide bond. These subunits are joined by a S-S bridge between DMSA and SPDP (Figure 4).…”

Fluorescence-Modified Superparamagnetic Nanoparticles: Intracellular Uptake and Use in Cellular Imaging

“…Over the past decade, numerous biomedical applications have emerged for superparamagnetic iron oxide nanoparticles dispersed in an aqueous medium. , The combination of the nanometer size with superparamagnetic properties led to their use in labeling and sorting cells or organelles, magnetic resonance imaging (MRI), targeted drug delivery, and hyperthermia. , The addition of fluorescence properties to these magnetic nanoparticles offers new potential for in vitro and in vivo imaging. The present study was motivated by the use of these bifunctional nanoparticles for medical imaging by combined MRI and fluorescence imaging techniques: ex vivo by classical fluorescence microscopy or in vivo via fibered confocal fluorescence microscopy .…”

“…Over the past decade, numerous biomedical applications have emerged for superparamagnetic iron oxide nanoparticles dispersed in an aqueous medium. 1,2 The combination of the nanometer size with superparamagnetic properties led to their use in labeling and sorting cells or organelles, 3 magnetic resonance imaging (MRI), 4 targeted drug delivery, 5 and hyperthermia. 6,7 The addition of fluorescence properties to these magnetic nanoparticles offers new potential for in vitro and in vivo imaging.…”

Surface modification of superparamagnetic nanoparticles (Ferrofluid) studied with particle electrophoresis: Application to the specific targeting of cells

“…Particle electrophoresis mobility (PEM) measurements using laser-Doppler velocimetry [ 10-121 have been reported to reveal surface charge modifications of nonmagnetic particles, and allowed us to study protein adsorption [13, 141 and to predict the physical stability of colloids [ l l , 15, 161. We therefore applied this methodology to study the immobilization of peroxidase-labeled proteins to our superparamagnetic colloidal particles, as the charged proteins linked to the particles would modify their net charge and subsequently their apparent electrophoretic mobility.…”