Magnetic Measurement of Cardiac Volume Changes

Katila, T.; Maniewski, Roman; Tuomisto, Timo; Varpula, Timo; Siltanen, P

doi:10.1109/tbme.1982.324959

Cited by 16 publications

(3 citation statements)

References 8 publications

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“…4. As proposed in the earlier MSPG literature, such data hold promise to permit extraction of physiological parameters and potentially of diagnostic information3435. Real-time recordings of greatly enhanced dynamic range, as reported here, render a major boost to these prospects.…”

Section: Resultsmentioning

confidence: 63%

“…As an example of the latter, we demonstrate the recording of dynamic susceptibility effects caused by the beating human heart when exposed to an external magnetic field. Termed magnetic susceptibility plethysmography (MSPG)34, such measurement has so far been limited to SQUID detection and thus to low background field3435. At field strengths below 1 mT, the method has yielded cardiac field SNR of about 20.…”

Section: Resultsmentioning

confidence: 99%

“…At field strengths below 1 mT, the method has yielded cardiac field SNR of about 20. To improve net sensitivity, MSPG signals have typically been averaged over large numbers of heartbeats, capturing only dominant features and no beat-to-beat variation35.…”

Section: Resultsmentioning

confidence: 99%

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Dynamic nuclear magnetic resonance field sensing with part-per-trillion resolution

et al. 2016

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High-field magnets of up to tens of teslas in strength advance applications in physics, chemistry and the life sciences. However, progress in generating such high fields has not been matched by corresponding advances in magnetic field measurement. Based mostly on nuclear magnetic resonance, dynamic high-field magnetometry is currently limited to resolutions in the nanotesla range. Here we report a concerted approach involving tailored materials, magnetostatics and detection electronics to enhance the resolution of nuclear magnetic resonance sensing by three orders of magnitude. The relative sensitivity thus achieved amounts to 1 part per trillion (10−12). To exemplify this capability we demonstrate the direct detection and relaxometry of nuclear polarization and real-time recording of dynamic susceptibility effects related to human heart function. Enhanced high-field magnetometry will generally permit a fresh look at magnetic phenomena that scale with field strength. It also promises to facilitate the development and operation of high-field magnets.

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Section: Resultsmentioning

confidence: 63%