Magnetic micropump embedded in contact lens for on-demand drug delivery

Wang, Cong; Park, Jungyul

doi:10.1186/s40486-019-0101-x

Cited by 25 publications

(22 citation statements)

References 22 publications

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“…The PDMS membrane was used as the main component, while a magnetic nanoparticle–PDMS composite (MNPC) was employed for the actuation under the magnetic field pulses. The final thickness of the sensor was less than 500 μm, which made it compatible for integration into a contact lens for drug delivery purposes [ 121 ].…”

Section: Contact Lenses For Drug Deliverymentioning

confidence: 99%

A Meta-Analysis of Wearable Contact Lenses for Medical Applications: Role of Electrospun Fiber for Drug Delivery

et al. 2022

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In recent years, wearable contact lenses for medical applications have attracted significant attention, as they enable continuous real-time recording of physiological information via active and noninvasive measurements. These devices play a vital role in continuous monitoring of intraocular pressure (IOP), noninvasive glucose monitoring in diabetes patients, drug delivery for the treatment of ocular illnesses, and colorblindness treatment. In specific, this class of medical devices is rapidly advancing in the area of drug loading and ocular drug release through incorporation of electrospun fibers. The electrospun fiber matrices offer a high surface area, controlled morphology, wettability, biocompatibility, and tunable porosity, which are highly desirable for controlled drug release. This article provides an overview of the advances of contact lens devices in medical applications with a focus on four main applications of these soft wearable devices: (i) IOP measurement and monitoring, (ii) glucose detection, (iii) ocular drug delivery, and (iv) colorblindness treatment. For each category and application, significant challenges and shortcomings of the current devices are thoroughly discussed, and new areas of opportunity are suggested. We also emphasize the role of electrospun fibers, their fabrication methods along with their characteristics, and the integration of diverse fiber types within the structure of the wearable contact lenses for efficient drug loading, in addition to controlled and sustained drug release. This review article also presents relevant statistics on the evolution of medical contact lenses over the last two decades, their strengths, and the future avenues for making the essential transition from clinical trials to real-world applications.

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Section: Contact Lenses For Drug Deliverymentioning

confidence: 99%

A Meta-Analysis of Wearable Contact Lenses for Medical Applications: Role of Electrospun Fiber for Drug Delivery

et al. 2022

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“…If the drugs to be incorporated are susceptible to degradation when exposed to UV or high temperatures, then the drug loading can be made successful by soaking the polymerized contact lens into solution containing the drug molecules. 204 Wang and Park 190 explored a contact lens with an on-demand drug delivery system, where a thin magnetic micropump is incorporated in the contact lens. The micropump with magnetic nanoparticle–PDMS composite (MNPC) for actuation has a check valve which is operated using an external magnetic field and not battery powered.…”

Section: Contact Lens Based Drug Delivery Systemsmentioning

confidence: 99%

Section: Contact Lens Based Drug Delivery Systemsmentioning

confidence: 99%

Ophthalmic Sensors and Drug Delivery

et al. 2021

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Advances in multifunctional materials and technologies have allowed contact lenses to serve as wearable devices for continuous monitoring of physiological parameters and delivering drugs for ocular diseases. Since the tear fluids comprise a library of biomarkers, direct measurement of different parameters such as concentration of glucose, urea, proteins, nitrite, and chloride ions, intraocular pressure (IOP), corneal temperature, and pH can be carried out non-invasively using contact lens sensors. Microfluidic contact lens sensor based colorimetric sensing and liquid control mechanisms enable the wearers to perform self-examinations at home using smartphones. Furthermore, drug-laden contact lenses have emerged as delivery platforms using a low dosage of drugs with extended residence time and increased ocular bioavailability. This review provides an overview of contact lenses for ocular diagnostics and drug delivery applications. The designs, working principles, and sensing mechanisms of sensors and drug delivery systems are reviewed. The potential applications of contact lenses in point-of-care diagnostics and personalized medicine, along with the significance of integrating multiplexed sensing units together with drug delivery systems, have also been discussed.

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“…Copyright 2019 Royal Society of Chemistry. (b) Schematic of magnetic field‐triggered CLs with a drug‐loading magnetic micropump for on‐demand drug release [87] . Reproduced with permission from Ref.…”

Section: New Cls Hydrogels Via Rational Copolymer Designmentioning

confidence: 99%

“…In order to make copolymer hydrogel more controllable, Wang and Park invented an implant of magnetic micropump to achieve an on‐demand drug delivery [87] . What's special is the on‐demand drug release which means you can activate it whenever you need with an external magnetic field but not electricity.…”

Section: New Cls Hydrogels Via Rational Copolymer Designmentioning

confidence: 99%

Recent Advances in New Copolymer Hydrogel‐Formed Contact Lenses for Ophthalmic Drug Delivery

Cheng

et al. 2021

ChemNanoMat

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Pharmaceuticals delivery to the eye sites of interest via the means of contact lenses (CLs) has attracted significant research attention in recent years. Compared with the conventional formulation in eye treatment such as eye drops, CLs administration has shown remarkable advantages in overcoming the challenges involved in ocular drug delivery such as higher bioavailability, longer drug residence and better medication compliance. This review will first detail each of the material components which have been used in the context of CLs, including HEMA, MAA, DMA, NVP, EGDMA, TRIS and PDMS. The pros and cons of each material in tailoring drug release rates of different encapsulated payloads will be discussed, with special focus on their impact on the therapeutic efficiency. In addition, the advancement of recent emerging copolymer CLs hydrogels, originated from these sophisticated monomers with distinct functions, are further summarized into several synthetic strategies in the means of copolymer architecture design and function‐performance relationship in ophthalmic applications. Finally, the possible considerations for future design of multifunctional CLs hydrogels by combing material selection rationales with biological interface science are proposed.

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Magnetic micropump embedded in contact lens for on-demand drug delivery

Cited by 25 publications

References 22 publications

A Meta-Analysis of Wearable Contact Lenses for Medical Applications: Role of Electrospun Fiber for Drug Delivery

A Meta-Analysis of Wearable Contact Lenses for Medical Applications: Role of Electrospun Fiber for Drug Delivery

Ophthalmic Sensors and Drug Delivery

Recent Advances in New Copolymer Hydrogel‐Formed Contact Lenses for Ophthalmic Drug Delivery

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