Magnetic-molecularly imprinted polymers in electrochemical sensors and biosensors

Marfà, J; Pupin, Rafael Rovatti; Sotomayor, Marı́a Del Pilar Taboada; Pividori, María Isabel

doi:10.1007/s00216-021-03461-x

Cited by 28 publications

(8 citation statements)

References 143 publications

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“…The RL values in the reported work were in the range of 1.2–3.5, higher than zero, demonstrating favorable sorption. Furthermore, advantageous sorption at a lower concentration was indicated by greater RL values at lower concentrations [ 39 , 40 ]. The results obtained as a result of isotherm study showed a feasible and satisfactory sorption ability of the MMIPs.…”

Section: Resultsmentioning

confidence: 99%

Biomimetic Electrochemical Sensors Based on Core-Shell Imprinted Polymers for Targeted Sunset Yellow Estimation in Environmental Samples

Malik

Khan

et al. 2023

Biosensors

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Magnetic molecularly imprinted polymers (MMIPs) contain the predesigned specialized recognition capability that can be chosen to build credible functional materials, that are easy to handle and have a good degree of specificity. Hence, the given piece of work is intended to design a novel electrochemical sensor incorporating magnetite-based molecularly imprinted polymers. The building materials consisted of a cross-linker (EGDMA), reaction-initiator (AIBN), monomer (methylene succinic acid-MSA), and template molecule (Sunset Yellow-SY dye). MMIPs exhibited a diameter of 57 nm with an irregular shape due to the presence of cavities based on SEM analysis. XRD patterns exhibited crystallinity, as well as amorphous peaks that are attributed to polymeric and non-polymeric frameworks of MMIPs. The crystallite size of the MMIPs from XRD analysis was found to be 16.28 nm based on the Debye-Scherrer’s equation. Meanwhile, the FTIR bands showed the synthesis of MMIPs using monomer and methylene succinic acid. The sorption data at the optimized operating conditions (pH 2, sorbent dosage 3 mg, time 18 min) showed the highest sorption capacity of 40 mg/g. The obtained data best fitted to the Langmuir sorption isotherm and followed the pseudo-second-order kinetics. The magneto-sensors were applied for ultrasensitive, rapid, and simple sensing of SY dye. The electrochemical experiments were run at the operating condition range of (scan rate 10–50 mV/s, tads 0–120 s, pH 5–9, potential range 1–1.5 V for CV and 1–1.3 V for SWAdASV). The linear range of detection was set to 1.51 × 10−6 M to 1.51 × 10−6 M posing LOD and LOQ values of 8.6242 × 10−5 M and 0.0002874 M, respectively. The regression analysis value for the calibration was found to be 0.950. Additionally, high adsorption efficiency, selectivity, reusability, and strong structural stability of the magneto-sensors showed potential use for SY detection in real samples. These characteristics make MMIPs a viable electrochemical substrate for the detection of chemical contaminants in the environment and in health-related products.

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Section: Resultsmentioning

confidence: 99%

Biomimetic Electrochemical Sensors Based on Core-Shell Imprinted Polymers for Targeted Sunset Yellow Estimation in Environmental Samples

Malik

Khan

et al. 2023

Biosensors

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“…Table 1 shows that Fe 3 O 4 is the most widely used magnetic component, showing a higher MS value than Ni and Co magnetic particles, with the highest value of 69 emu/g. Marfà et al indicated that magnetite (Fe 3 O 4 ) is the most widely used due to its biocompatibility, strong superparamagnetism, good catalytic activity and simple preparation procedure [ 67 ]. Other reasons include its low toxicity, good biocompatibility, fast magnetic susceptibility and high surface area, making it the most commonly used support [ 7 ].…”

Section: Synthesis Of Mmipmentioning

confidence: 99%

Factors Affecting the Analytical Performance of Magnetic Molecularly Imprinted Polymers

et al. 2022

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During the last few years, separation techniques using molecular imprinting polymers (MIPs) have been developed, making certain improvements using magnetic properties. Compared to MIP, Magnetic molecularly imprinted polymers (MMIPs) have high selectivity in sample pre-treatment and allow for fast and easy isolation of the target analyte. Its magnetic properties and good extraction performance depend on the MMIP synthesis step, which consists of 4 steps, namely magnetite manufacture, magnetic coating using modified components, polymerization and template desorption. This review discusses the factors that will affect the performance of MMIP as a selective sorbent at each stage. MMIP, using Fe3O4 as a magnetite core, showed strong superparamagnetism; it was prepared using the co-precipitation method using FeCl3·6H2O and FeCl2·H2O to obtain high magnetic properties, using NH4OH solution added for higher crystallinity. In magnetite synthesis, the use of a higher temperature and reaction time will result in a larger nanoparticle size and high magnetization saturation, while a higher pH value will result in a smaller particle size. In the modification step, the use of high amounts of oleic acid results in smaller nanoparticles; furthermore, determining the correct molar ratio between FeCl3 and the shielding agent will also result in smaller particles. The next factor is that the proper ratio of functional monomer, cross-linker and solvent will improve printing efficiency. Thus, it will produce MMIP with high selectivity in sample pre-treatment.

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“…Based on the interaction of functional monomers and target molecules, MIPs are of three types: covalent, semi-covalent, and non-covalent interactions. The system explores various detection principles, such as affinity-based sensors [ 132 ] and electrochemical methods [ 133 ]. Optical-based detection methods detect E. coli O157:H7 by employing the electrochemiluminescence (ECL) method.…”

Section: Biosensors For Pathogen Detectionmentioning

confidence: 99%

Emerging Bioanalytical Devices and Platforms for Rapid Detection of Pathogens in Environmental Samples

et al. 2022

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The development of robust bioanalytical devices and biosensors for infectious pathogens is progressing well with the advent of new materials, concepts, and technology. The progress is also stepping towards developing high throughput screening technologies that can quickly identify, differentiate, and determine the concentration of harmful pathogens, facilitating the decision-making process for their elimination and therapeutic interventions in large-scale operations. Recently, much effort has been focused on upgrading these analytical devices to an intelligent technological platform by integrating them with modern communication systems, such as the internet of things (IoT) and machine learning (ML), to expand their application horizon. This review outlines the recent development and applications of bioanalytical devices and biosensors to detect pathogenic microbes in environmental samples. First, the nature of the recent outbreaks of pathogenic microbes such as foodborne, waterborne, and airborne pathogens and microbial toxins are discussed to understand the severity of the problems. Next, the discussion focuses on the detection systems chronologically, starting with the conventional methods, advanced techniques, and emerging technologies, such as biosensors and other portable devices and detection platforms for pathogens. Finally, the progress on multiplex assays, wearable devices, and integration of smartphone technologies to facilitate pathogen detection systems for wider applications are highlighted.

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Magnetic-molecularly imprinted polymers in electrochemical sensors and biosensors

Cited by 28 publications

References 143 publications

Biomimetic Electrochemical Sensors Based on Core-Shell Imprinted Polymers for Targeted Sunset Yellow Estimation in Environmental Samples

Biomimetic Electrochemical Sensors Based on Core-Shell Imprinted Polymers for Targeted Sunset Yellow Estimation in Environmental Samples

Factors Affecting the Analytical Performance of Magnetic Molecularly Imprinted Polymers

Emerging Bioanalytical Devices and Platforms for Rapid Detection of Pathogens in Environmental Samples

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