Magnetic Nanocomposite Sol–Gel Systems for Remote Controlled Drug Release

Hawkins, Ashley M.; Bottom, Chelsie E.; Liang, Zhi; Puleo, David A.; Hilt, J. Zach

doi:10.1002/adhm.201100013

Cited by 23 publications

(20 citation statements)

References 37 publications

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“…58 The nanocomposite sol-gel can be easily injected percutaneously into a patient where the system will automatically gel upon reaching physiological temperatures (Fig. 8(A)).…”

Section: Application Of Nanocomposite Hydrogelsmentioning

confidence: 99%

Nanocomposite Hydrogels and Their Applications in Drug Delivery and Tissue Engineering

Song¹,

Li²,

Wang³

et al. 2015

j biomed nanotechnol

226

103

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Traditional hydrogels usually possess inferior mechanical properties as well as lacking multi-functionalities. Nano-sized particles/fillers, both inorganic and organic materials, have unique chemical, physical, and biological functions, and have been extensively studied as biomaterials or bio-functional materials. Nanocomposite hydrogels, which combine the advantages of both nano-fillers and hydrogel matrices, may result in improved mechanical and biological properties and find their potential applications in biomedical field. This paper reviews recent developments in the synthesis, preparation, and characterization of nanocomposite hydrogels; their biomedical applications, such as drug delivery matrices and tissue engineering scaffolding materials are also summarized.

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“…58 The nanocomposite sol-gel can be easily injected percutaneously into a patient where the system will automatically gel upon reaching physiological temperatures (Fig. 8(A)).…”

Section: Application Of Nanocomposite Hydrogelsmentioning

confidence: 99%

Nanocomposite Hydrogels and Their Applications in Drug Delivery and Tissue Engineering

Song¹,

Li²,

Wang³

et al. 2015

j biomed nanotechnol

226

103

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“…For example, thermoresponsive magnetic hydrogels were developed by Campbell et al who showed a fourfold enhancement of drug release. Other magnetic thermoresponsive nanocomposites based on the combination of certain polymers, nanogels, or lipids, together with iron oxide NPs, were developed in which therapeutic compounds (or drug models), such as lysozyme, sodium fluorescein, ibuprofen (IBU), and nifedepin, were released by the triggered thermal effect of a remote AMF ( Figure ) …”

Section: Representative Biomedical Applicationsmentioning

confidence: 99%

Advances in Magnetic Nanoparticles for Biomedical Applications

Cardoso

Francesko

Ribeiro

et al. 2017

Adv Healthcare Materials

548

330

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Magnetic nanoparticles (NPs) are emerging as an important class of biomedical functional nanomaterials in areas such as hyperthermia, drug release, tissue engineering, theranostic, and lab-on-a-chip, due to their exclusive chemical and physical properties. Although some works can be found reviewing the main application of magnetic NPs in the area of biomedical engineering, recent and intense progress on magnetic nanoparticle research, from synthesis to surface functionalization strategies, demands for a work that includes, summarizes, and debates current directions and ongoing advancements in this research field. Thus, the present work addresses the structure, synthesis, properties, and the incorporation of magnetic NPs in nanocomposites, highlighting the most relevant effects of the synthesis on the magnetic and structural properties of the magnetic NPs and how these effects limit their utilization in the biomedical area. Furthermore, this review next focuses on the application of magnetic NPs on the biomedical field. Finally, a discussion of the main challenges and an outlook of the future developments in the use of magnetic NPs for advanced biomedical applications are critically provided.

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“…Researchers have applied the remote heating capability of MNPs to trigger various thermal transitions in macroscale materials or systems [46–63], and in the following, we highlight a few recent examples of novel materials and systems where AMF triggered thermal transitions resulted in modulated release of a drug. In one strategy, Campbell et al developed nanocomposite systems designed to be in situ-gelling and thus injectable [48, 49].…”

Section: Remote Controlled Drug Therapymentioning

confidence: 99%

“…In another example of a thermoresponsive injectable systems, Hawkins et al developed a nanocomposite sol-gel system based on Pluronic ® F-127 and iron oxide MNPs [46]. When exposed to an AMF (296 kHz, 27.9 kA/m), it was demonstrated that pulsatile release of lysozyme could be achieved, although only over short time frames for the system composition studied.…”

Section: Remote Controlled Drug Therapymentioning

confidence: 99%

Magnetic nanoparticles and nanocomposites for remote controlled therapies

Hauser

Wydra

Stocke

et al. 2015

Journal of Controlled Release

Self Cite

108

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This review highlights the state-of-the-art in the application of magnetic nanoparticles (MNPs) and their composites for remote controlled therapies. Novel macro- to nano-scale systems that utilize remote controlled drug release due to actuation of MNPs by static or alternating magnetic fields and magnetic field guidance of MNPs for drug delivery applications are summarized. Recent advances in controlled energy release for thermal therapy and nanoscale energy therapy are addressed as well. Additionally, studies that utilize MNP-based thermal therapy in combination with other treatments such as chemotherapy or radiation to enhance the efficacy of the conventional treatment are discussed.

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Magnetic Nanocomposite Sol–Gel Systems for Remote Controlled Drug Release

Cited by 23 publications

References 37 publications

Nanocomposite Hydrogels and Their Applications in Drug Delivery and Tissue Engineering

Nanocomposite Hydrogels and Their Applications in Drug Delivery and Tissue Engineering

Advances in Magnetic Nanoparticles for Biomedical Applications

Magnetic nanoparticles and nanocomposites for remote controlled therapies

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