Magnetic Nanoparticle Degradation in vivo Studied by Mössbauer Spectroscopy

Nikitin, Maxim P.; Gabbasov, R. R.; Черепанов, В. М.; Чуев, М. А.; Поликарпов, М. А.; Panchenko, V. Ya.; Deyev, Sergey M.

doi:10.1063/1.3530046

Cited by 19 publications

(10 citation statements)

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“…A change in the crystal structure as a result of a decrease in the degree of perfection and the formation of amorphous inclusions can lead to magnetic disordering and a subsequent change in the magnitude of the hyperfine magnetic field. The results of a change in the magnitude of the hyperfine magnetic field, determined by Mössbauer spectroscopy, depending on the time of degradation, show that an increase in the degradation time leads to a change in the structural characteristics and the formation of amorphous inclusions in the structure, which in turn leads to a decrease in the magnitude of the hyperfine magnetic field [70,71]. This is due to the formation of cationic vacancies and impurity inclusions in the structure, as well as the disordering of the magnetic texture [72].…”

Section: Resultsmentioning

confidence: 99%

Fe3O4 Nanoparticles for Complex Targeted Delivery and Boron Neutron Capture Therapy

et al. 2019

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Magnetic Fe3O4 nanoparticles (NPs) and their surface modification with therapeutic substances are of great interest, especially drug delivery for cancer therapy, including boron-neutron capture therapy (BNCT). In this paper, we present the results of boron-rich compound (carborane borate) attachment to previously aminated by (3-aminopropyl)-trimethoxysilane (APTMS) iron oxide NPs. Fourier transform infrared spectroscopy with Attenuated total reflectance accessory (ATR-FTIR) and energy-dispersive X-ray analysis confirmed the change of the element content of NPs after modification and formation of new bonds between Fe3O4 NPs and the attached molecules. Transmission (TEM) and scanning electron microscopy (SEM) showed Fe3O4 NPs’ average size of 18.9 nm. Phase parameters were studied by powder X-ray diffraction (XRD), and the magnetic behavior of Fe3O4 NPs was elucidated by Mössbauer spectroscopy. The colloidal and chemical stability of NPs was studied using simulated body fluid (phosphate buffer—PBS). Modified NPs have shown excellent stability in PBS (pH = 7.4), characterized by XRD, Mössbauer spectroscopy, and dynamic light scattering (DLS). Biocompatibility was evaluated in-vitro using cultured mouse embryonic fibroblasts (MEFs). The results show us an increasing of IC50 from 0.110 mg/mL for Fe3O4 NPs to 0.405 mg/mL for Fe3O4-Carborane NPs. The obtained data confirm the biocompatibility and stability of synthesized NPs and the potential to use them in BNCT.

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Section: Resultsmentioning

confidence: 99%

Fe3O4 Nanoparticles for Complex Targeted Delivery and Boron Neutron Capture Therapy

et al. 2019

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“…However, considerable attention needs to be paid to the human and environmental risks of these materials. For this reason, it is important to evaluate the level and degree of toxicity, biocompat-ibility, and biodegradation of nanomaterials [251][252][253]. So far, CNMs still exhibit a toxic effect on biological systems.…”

Section: Toxicity Studies Of Carbon Nanomaterialsmentioning

confidence: 99%

Applications of Pristine and Functionalized Carbon Nanotubes, Graphene, and Graphene Nanoribbons in Biomedicine

et al. 2021

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This review is dedicated to a comprehensive description of the latest achievements in the chemical functionalization routes and applications of carbon nanomaterials (CNMs), such as carbon nanotubes, graphene, and graphene nanoribbons. The review starts from the description of noncovalent and covalent exohedral modification approaches, as well as an endohedral functionalization method. After that, the methods to improve the functionalities of CNMs are highlighted. These methods include the functionalization for improving the hydrophilicity, biocompatibility, blood circulation time and tumor accumulation, and the cellular uptake and selectivity. The main part of this review includes the description of the applications of functionalized CNMs in bioimaging, drug delivery, and biosensors. Then, the toxicity studies of CNMs are highlighted. Finally, the further directions of the development of the field are presented.

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“…Specifically, they are used in magnetic separation of biomolecules, magnetofection–delivery of genetic material inside cells, magnetically guided drug delivery, magnetic hyperthermia, and as reporting probes for various magnetism-based detection and imaging techniques such as MRI, , magnetic particle quantification (MPQ) method, ,− and magnetic particle imaging (MPI) . Among other magnetic nanomaterials, iron oxide nanoparticles [magnetite (Fe 3 O 4 ) and maghemite (γ-Fe 2 O 3 )] have received significant attention in biomedicine because of low cost, straightforward preparation and surface functionalization, biocompatibility, and biodegradation. , Importantly, a few magnetic nanoparticles have been approved for intravenous injections to humans as a contrast agent (Ferucarbotran for contrast enhancement MRI of liver) and for treatment of iron deficiency (Ferumoxytol). The efficacy and precision of these techniques can be brought to a principally new level when using magnetic nanoparticles with built-in biocomputing interfaces.…”

Section: Logic-gated Nanoagents For Specific Biomedical Applicationsmentioning

confidence: 99%

Advanced Smart Nanomaterials with Integrated Logic-Gating and Biocomputing: Dawn of Theranostic Nanorobots

2018

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Accurate and precise drug delivery is the key to successful therapy. Monoclonal antibodies, which can transport therapeutic payload to cells expressing specific markers, have paved the way for targeted drug delivery and currently show tremendous clinical success. However, in those abundant cases, when a disease cannot be characterized by a single specific marker, more sophisticated drug delivery systems are required. To enhance targeting accuracy, diverse smart materials have been proposed that can also react to stimuli like variations of pH, temperature, magnetic field, etc. Furthermore, over the past few years a new category of smart materials has emerged, which can not only respond to virtually any biochemical or physical stimulus but also simultaneously analyze several cues and, moreover, can be programmed to use Boolean logic for such analysis. These advanced biocomputing agents have the potential to become a basis for future nanorobotic devices that could overcome some of the grand challenges of modern biomedicine. Here, with a brief introduction to the multidisciplinary field of biomolecular computing, we will review the concepts of nanomaterials with built-in biocomputing capabilities, which can be potentially used for drug delivery and other theranostic applications.

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Magnetic Nanoparticle Degradation in vivo Studied by Mössbauer Spectroscopy

Cited by 19 publications

References 0 publications

Fe3O4 Nanoparticles for Complex Targeted Delivery and Boron Neutron Capture Therapy

Fe3O4 Nanoparticles for Complex Targeted Delivery and Boron Neutron Capture Therapy

Applications of Pristine and Functionalized Carbon Nanotubes, Graphene, and Graphene Nanoribbons in Biomedicine

Advanced Smart Nanomaterials with Integrated Logic-Gating and Biocomputing: Dawn of Theranostic Nanorobots

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