Magnetic Nanoparticle-Supported Lipid Bilayers for Drug Delivery

Abstract

Magnetic nanoparticle-supported lipid bilayers (SLBs) constructed around core-shell Fe3O4-SiO2 nanoparticles (SNPs) were prepared and evaluated as potential drug carriers. We describe how an oxime ether lipid can be mixed with SNPs to produce lipid-particle assemblies with highly positive ζ potential. To demonstrate the potential of the resultant cationic SLBs, the particles were loaded with either the anticancer drug doxorubicin or an amphiphilic analogue, prepared to facilitate integration into the supported lipid bilayer, and then examined in studies against MCF-7 breast cancer cells. The assemblies were rapidly internalized and exhibited higher toxicity than treatments with doxorubicin alone. The magnetic SLBs were also shown to increase the efficacy of unmodified doxorubicin.

Electric double layer electrostatics of lipid‐bilayer‐encapsulated nanoparticles: Toward a better understanding of protocell electrostatics

“…Figure shows the radial variation of for the LBLENP with a metallic NP core. Results are shown as parametric variations of and σ (both positive and negative ). No electrostatic potential exists within the NP and the charge density is zero at the NP‐membrane interface.…”

“…To the best of our knowledge, this is possibly the first systematic theoretical study on the electrostatic behavior of the LBLENPs (specifically protcoells). As elucidated in great details at the end of the paper, we anticipate that our findings will be immensely useful for a number of practical applications such as (a) understanding the role of electrostatics in the performance of magnetic NP supported positively charged cationic LBLs for drug delivery to negatively charged cancer cells , (b) probing the role of electrostatics in ensuring that the protocells retain their cargo in various types of environment , (c) designing electrostatically motivated lipid exchanges for altering the functionalities of the protocells , (d) controlling electrostatically mediated interactions between LBLs and curvature sensitive proteins (like SpoVM) , (e) regulating electrostatic effects in improving gene delivery , and many more.…”

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

“…On the other hand, numerous therapeutic applications of MNPs have been widely investigated during the last decades. Thermal ablation and hyperthermia, [26] targetable drug delivery, [27] tissue engineering, [28] gene delivery (transfection), [29] cell or DNA purification and separation [30] are of some most important therapeutic applications facilitated by the novel MNP theranostic agents.…”

Vincristine and temozolomide combined chemotherapy for the treatment of glioma: a comparison of solid lipid nanoparticles and nanostructured lipid carriers for dual drugs delivery

“…Due to the physicochemical properties of lipids, lipid-based nanocarriers can be easily obtained by direct emulsification of the molten lipids and subsequent recrystallization, avoiding the use of potentially toxic solvents that are commonly required for the preparation of other kinds of nanocarriers (Fathi-Azarbayjani et al, 2015;Mattingly et al, 2015). Among the different types of lipid-based nanoparticles, solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have come up as the latest development in the arena of lipid-based colloidal delivery systems after nanoemulsion and liposomes (Müller et al, 2011).…”