Magnetic Nanostructure-Coated Thermoresponsive Hydrogel Nanoconstruct As a Smart Multimodal Theranostic Platform

Abstract

Here we report design of a smart nanoconstruct that can be used as a multimodal theranostic platform for imaging and therapy applications. Decorated with two sizes of magnetic nanostructures (MNS) on thermoresponsive nanosized hydrogel (NG), the NG-MNS nanoconstruct shows dual-mode contrast enhancement ability in MRI and thermo-chemo therapeutic ability under an RF field. Because of the unique design where all MNS are at the exterior of the nanoconstruct, no compromise in the physical properties of MNS and their effect on contrast enhancement and thermal activation has been observed. In a series of in vitro analyses in human breast adenocarcinoma (MDA-MB-231) cells, we validate that NG-MNS show dual-mode MR imaging capability with a higher signal/noise ratio than in clinically approved dual-mode contrast agents as well as enhanced therapeutic efficacy compared to previously reported hydrogel-based nanocarriers and free drug systems.

Nanofibrillar Hydrogels by Temperature Driven Self‐Assembly: New Structures for Cell Growth and Their Biological and Medical Implications

“…[ 85 ] New methods are sought for developing fiber‐like interfaces, and temperature represents an attractive method for producing such structures. [ 86 ] Transforming morphology of hydrogel coatings into nano‐ and microfibers is relevant to biological applications.…”

Revealing the NIR-triggered chemotherapy therapeutic window of magnetic and thermoresponsive nanogels

“…In this regard, iron oxide magnetic nanoparticles (MNPs) present several advantages that makes them perhaps the best choice as phototransducers: (a) they are capable of transducing NIR light into heat, 20,21 (b) MNPs also generate heat when excited with an alternating magnetic field, [22][23][24][25] (c) their paramagnetic properties make them optimal candidates for magnetic resonance imaging (MRI) contrast agents, [26][27][28][29] and (d) magnet guided therapy can be performed with these systems as well. [30][31][32][33] Because of the above-mentioned reasons, many efforts have been focused on the development of magnetic and thermoresponsive nanogels (MNGs). [34][35][36] A variety of approaches that use non-covalent interactions have been considered for the incorporation of MNPs into a nanogel's polymeric matrix.…”

“…[34][35][36] A variety of approaches that use non-covalent interactions have been considered for the incorporation of MNPs into a nanogel's polymeric matrix. These range from a simple mixture of MNPs and nanogel suspensions 20,32,37 to the in situ synthesis of nanogels in the presence of a solution of MNPs, 35,38,39 or vice versa by the in situ synthesis of MNPs in a nanogel dispersion. 40,41 However, the non-covalent incorporation methods have important drawbacks like the desorption of the MNPs or the aggregation of the particles inside the nanogels that affects both the magnetic properties of the composites and the drug loading capacity of the systems.…”

Drug release and magneto-calorific analysis of magnetic lipid microcapsules for potential cancer therapeutics

“…When the Fe concentration was fixed at 20.0 μg/mL, the maximum release percentage at 100 Hz was 8%, while it reached to 53% at a frequency of 5 kHz after 120 min. The total release rate decreased gradually with time at every frequency because the CF concentration gradient between the inside and outside of the MLMs decreased, reducing the driving force of the release [ 3 , 18 ]. According to magneto-caloric theory, frequency plays a key role in inducing the magnetic heating generation of MNPs in an AMF.…”

“…Drug delivery carriers based on MNPs are explored intensively in biomedical field to amplify drug efficacy in clinical treatment such as remote-controlled drug release at the desired targeted regions or active pathology by magnetic hyperthermia under an alternating magnetic field (AMF) [ 1 ]. Because of their disadvantages of aggregation and precipitation[ 2 ], safe and stable MNPs are the precondition to expand their actual clinic application [ 3 , 4 ]. Organic materials [ 5 , 6 ], inorganic materials [ 7 , 8 ], and biomaterials [ 9 , 10 ] have been designed to composite with MNPs and further fabricate magnetic drug delivery carriers.…”