Magnetic nanovectors for drug delivery

Klostergaard, Jim; Seeney, Charles E.

doi:10.1016/j.maturitas.2012.01.019

Cited by 33 publications

(25 citation statements)

References 107 publications

(116 reference statements)

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“…However, considering the potential toxicity to the body, the number of usable elements is severely limited 9. From this perspective, magnetite (Fe 3 O 4 ) is the most promising material because of its low toxicity and relatively high saturation magnetization ( M s ) 4,9. Furthermore, Fe 3 O 4 is already used as a contrast agent for magnetic resonance imaging (MRI) in clinical practice 1.…”

Section: Introductionmentioning

confidence: 99%

Magnetically Responsive Smart Nanoparticles for Cancer Treatment with a Combination of Magnetic Hyperthermia and Remote-Control Drug Release

Hayashi¹,

et al. 2014

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We report the synthesis of smart nanoparticles (NPs) that generate heat in response to an alternating current magnetic field (ACMF) and that sequentially release an anticancer drug (doxorubicin, DOX). We further study the in vivo therapeutic efficacy of the combination of magnetic hyperthermia (MHT) and chemotherapy using the smart NPs for the treatment of multiple myeloma. The smart NPs are composed of a polymer with a glass-transition temperature (Tg) of 44°C, which contains clustered Fe3O4 NPs and DOX. The clustered Fe3O4 NPs produce heat when the ACMF is applied and rise above 44°C, which softens the polymer phase and leads to the release of DOX. The combination of MHT and chemotherapy using the smart NPs destroys cancer cells in the entire tumor and achieves a complete cure in one treatment without the recurrence of malignancy. Furthermore, the smart NPs have no significant toxicity.

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Section: Introductionmentioning

confidence: 99%

Magnetically Responsive Smart Nanoparticles for Cancer Treatment with a Combination of Magnetic Hyperthermia and Remote-Control Drug Release

Hayashi¹,

et al. 2014

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“…Factors such as magnetic structure, particle size, surface chemistry, and surface charge typically determine the magnetic response and physical or chemical interactions of the nanoparticles with biological entities during application. Emerging novel applications are focused on the development of magnetic nanoparticles as targeted magnetic carriers for drug delivery (Klostergaard and Seeney 2012; Gautier et al 2012; Manju and Sreenivasan 2011; Chen et al 2011; Veiseh et al 2010), the usage of magnetic nanoparticles as specific contrast enhancement agents for in vivo magnetic resonance imaging (MRI) (Jung et al 2011; Bhattacharya et al 2011), protein immobilization (Huang et al 2010; Li et al 2010), magnetic cell sorting (Xu et al 2011; Chen et al 2011), and biocompatible magnetic nanoparticles for cancer treatment mediated by hyperthermia (Creixell et al 2011; Mikhaylov and Vasiljeva 2011; Laurent et al 2011; Arias et al 2011). …”

Section: Introductionmentioning

confidence: 99%

Effect of surface charge on the colloidal stability and in vitro uptake of carboxymethyl dextran-coated iron oxide nanoparticles

et al. 2013

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Nanoparticle physicochemical properties such as surface charge are considered to play an important role in cellular uptake and particle–cell interactions. In order to systematically evaluate the role of surface charge on the uptake of iron oxide nanoparticles, we prepared carboxymethyl-substituted dextrans with different degrees of substitution, ranging from 38 to 5 groups per chain, and reacted them using carbodiimide chemistry with amine–silane-coated iron oxide nanoparticles with narrow size distributions in the range of 33–45 nm. Surface charge of carboxymethyl-substituted dextran-coated nano-particles ranged from −50 to 5 mV as determined by zeta potential measurements, and was dependent on the number of carboxymethyl groups incorporated in the dextran chains. Nanoparticles were incubated with CaCo-2 human colon cancer cells. Nanoparticle–cell interactions were observed by confocal laser scanning microscopy and uptake was quantified by elemental analysis using inductively coupled plasma mass spectroscopy. Mechanisms of internalization were inferred using pharmacological inhibitors for fluid-phase, clathrin-mediated, and caveola-mediated endocytosis. Results showed increased uptake for nanoparticles with greater negative charge. Internalization patterns suggest that uptake of the most negatively charged particles occurs via non-specific interactions.

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“…[1][2][3] From the past few decades, nanosized iron oxide particles have attracted great attention in the fields including, but not limited to, immunoassay, 4,5 biosensor, 6,7 bioseparation, 8,9 targeted drug delivery, 10,11 and environmental analysis 12,13 and protein immobilization. [14][15][16][17][18][19][20][21] However, the bare Fe 3 O 4 NPs have high reactivity and easily undergo degradation upon direct exposing to certain environment, leading to poor stability and dispersity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Magnetic Nanoparticles and Its Application in Lipase Immobilization

Xu¹,

Ju²,

Sheng³

et al. 2013

Bulletin of the Korean Chemical Society

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We demonstrate herein the synthesis and modification of magnetic nanoparticles and its use in the immobilization of the lipase. Magnetic Fe 3 O 4 nanoparticles (MNPs) were prepared by simple co-precipitation method in aqueous medium and then subsequently modified with tetraethyl orthosilicate (TEOS) and 3-aminopropyl triethylenesilane (APTES). Silanization magnetic nanoparticles (SMNP) and amino magnetic nanomicrosphere (AMNP) were synthesized successfully. The morphology, structure, magnetic property and chemical composition of the synthetic MNP and its derivatives were characterized using transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR) analysis, X-ray diffraction, superconducting quantum interference device (SQUID) and thermogravimetric analyses (TGA). All of these three nanoparticles exhibited good crystallization performance, apparent superparamagnetism, and the saturation magnetization of MNP, SMNP, AMNP were 47.9 emu/g, 33.0 emu/g and 19.5 emu/g, respectively. The amino content was 5.66%. The AMNP was used to immobilize lipase, and the maximum adsorption capacity of the protein was 26.3 mg/g. The maximum maintained activity (88 percent) was achieved while the amount of immobilized lipase was 23.7 mg g −1. Immobilization of enzyme on the magnetic nanoparticles can facilitate the isolation of reaction products from reaction mixture and thus lowers the cost of enzyme application.

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Magnetic nanovectors for drug delivery

Cited by 33 publications

References 107 publications

Magnetically Responsive Smart Nanoparticles for Cancer Treatment with a Combination of Magnetic Hyperthermia and Remote-Control Drug Release

Magnetically Responsive Smart Nanoparticles for Cancer Treatment with a Combination of Magnetic Hyperthermia and Remote-Control Drug Release

Effect of surface charge on the colloidal stability and in vitro uptake of carboxymethyl dextran-coated iron oxide nanoparticles

Synthesis and Characterization of Magnetic Nanoparticles and Its Application in Lipase Immobilization

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