Magnetic properties of the MRI enhancement agent Feridex from Mössbauer spectra

Hah, Hien-Yoong; Williams, Austin; Pham, Wellington; Johnson, C. E.; Johnson, Jeffery L.

doi:10.1007/s10751-021-01739-1

Cited by 3 publications

(1 citation statement)

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“…As iron concentration of nanosystem rose from 0 to 0.37 mM, Figure 1C demonstrated that the MR- T 2 weighted (T 2 WI) image signal decreased significantly, which was caused by the superparamagnetic property of iron oxide crystals in IR780@BSA@SPIO that reduced the transverse relaxation time of hydrogen nuclei in water and resulted in a dark color on the MR image. The correlation between the reciprocal T 2 relaxation time and the concentration of IR780@BSA@SPIO was strong, with the fitting results revealing that the relaxation rate was 307.57 mM −1 s −1 based on the fitting results; and it was roughly three times greater than that of commercially available Feridex @ (63.8 nm, 98.4 mM −1 s −1 ) [ 28 ]. Consequently, the T 1 relaxivity was about 2.00 /mM −1 s −1 ( Supplementary Figure S2 ), leading to a R 2 to R 1 ratio that was far in excess of 20, making the nanosystem an outstanding T 2 contrast agent.…”

Section: Resultsmentioning

confidence: 99%

Albumin-based nanosystem for dual-modality imaging-guided chem-phototherapy against immune-cold triple-negative breast cancer

Peng,

Zeng,

Cai

et al. 2023

Regenerative Biomaterials

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Triple-negative breast cancer is a highly aggressive and metastatic tumor; diagnosing it in the early stages is still difficult, and the prognosis for conventional radio-chemotherapy and immunotreatment is not promising due to cancer’s immunosuppressive microenvironment. The utilization of protein-based nanosystem has proven to be effective in delivering agents with limited adverse effects, yet the combination of diagnosis and treatment remains a difficult challenge. This research took advantage of natural albumin and organic molecules to construct a self-assemble core-shell nanostructure combining with superparamagnetic iron oxide nanocrystals and heptamethine cyanine dye IR780 through non-covalent interactions. This nanocomposite successfully decreased the transverse relaxation time of the magnetic resonance hydrogen nucleus, resulting in outstanding T2 imaging, as well as emitting near-infrared II fluorescence, thereby the resulting dual-modality imaging tool was applied to improve diagnostic competency. It is noteworthy that the nanocomposites exhibited impressive enzyme-like catalytic and photothermal capabilities, resulting in a successful activation of the immune system to efficiently suppress distant metastatic lesions in vivo. Consequently, this nanodrug-based therapy could be an advantageous asset in reinforcing the immune system and hindering the growth and reappearance of the immune-cold breast cancer.

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Section: Resultsmentioning

confidence: 99%